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GPCR/G Protein Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2. They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.
Cat No. product name
T0030 Bupivacaine hydrochloride Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membran...
T0159 Pranoprofen Pranoprofen (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
T0795 Rutin Rutin, a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
T1626 Alprostadil Alprostadil is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that...
T1978 GW 627368X GW627368X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
T2538 Bimatoprost Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
T2786 Oxysophocarpine Oxysophocarpine is extracted from Sophra flavescens Ait.
T2868 Evodiamine Evodiamine, an indole alkaloid found in Evodia rutaescarpa, acts as an anti-inflammatory compound.
T3174 Taprenepag Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of...
T3306 PF-04418948 PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3,...
T3889 Platycodin D Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat perito...
T3903 Angoroside C Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxida...
T6485 Embelin Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T4546 Dinoprost Tromethamine Dinoprost(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
T7053 p-Hydroxy-cinnamic acid p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin ...
T5014 Prostaglandin E2 (PGE2) Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dil...
T5150 Treprostinil Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T5171 Treprostinil Sodium Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T0002 Etamsylate Ethamsylate usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action...
T5386 Asapiprant Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor.
T5482 TG4-155 TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 μM) and a panel of other receptors and channe...
T5681 ETHYL CAFFEATE ETHYL CAFFEATE is a Cox-2, iNOS, NOS II, and PGE2 inhibitor,and have antiarthritic effect in collagen-induced arthritis (CIA) mice, its mechanism of action i...
T5774 7-demethylsuberosin 7-demethylsuberosin is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited inhibitory effects on PGE2 produc...
T5758 sphondin Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
T5841 Travoprost Travoprost is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
T5847 Cloprostenol sodium Cloprostenol sodium is a more water solute, crystalline form of cloprostenol than the free acid, is a synthetic analog of prostaglandin F2α.
T7652 AM211 Ipatasertib (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.
TQ0025 E7046 E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
TQ0203 Tafluprost Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.
TQ0290 ONO-AE3-208 ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
TQ0292 Grapiprant Grapiprant (CJ-023423) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 2...
T4981 Anisotropine Methylbromide Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
T4635 Ralinepag Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP r...
T7968 Dazoxiben Dazoxiben is a potent inhibitor of thromboxane (TX) synthase 
TN1006 Tirucallol Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.
TN1171 1-Dehydro-6-gingerdione 1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
TN1257 3-O-Acetyl-alpha-boswellic acid 3-O-Acetyl-alpha-boswellic acid has strong anti-inflammatory activity.
TN1650 Friedelin Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
TN1874 Liriodendrin Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
TN2115 Pseudohypericin Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS.
TN2169 Saikogenin D Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation o...
TN1009 Epimagnolin B Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the ...
TN1077 Taraxerol Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
TN1131 Handelin Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
TN1362 Afzelin Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may prote...
TN1406 Aromadendrin Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear t...
TN1485 Chicanine Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
TN1524 Continentalic acid Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis.
TN1622 Ermanin Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent ac...
TN1019 Beta-mangostin Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
Bupivacaine hydrochloride
T0030CAS 18010-40-7
Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membran...
Pranoprofen
T0159CAS 52549-17-4
Pranoprofen (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
Rutin
T0795CAS 153-18-4
Rutin, a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
Alprostadil
T1626CAS 745-65-3
Alprostadil is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that...
GW 627368X
T1978CAS 439288-66-1
GW627368X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
Bimatoprost
T2538CAS 155206-00-1
Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
Oxysophocarpine
T2786CAS 26904-64-3
Oxysophocarpine is extracted from Sophra flavescens Ait.
Evodiamine
T2868CAS 518-17-2
Evodiamine, an indole alkaloid found in Evodia rutaescarpa, acts as an anti-inflammatory compound.
Taprenepag
T3174CAS 752187-80-7
Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of...
PF-04418948
T3306CAS 1078166-57-0
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3,...
Platycodin D
T3889CAS 58479-68-8
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat perito...
Angoroside C
T3903CAS 115909-22-3
Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxida...
Embelin
T6485CAS 550-24-3
Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
Dinoprost Tromethamine
T4546CAS 38562-01-5
Dinoprost(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
p-Hydroxy-cinnamic acid
T7053CAS 7400-08-0
p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin ...
Prostaglandin E2 (PGE2)
T5014CAS 363-24-6
Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dil...
Treprostinil
T5150CAS 81846-19-7
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
Treprostinil Sodium
T5171CAS 289480-64-4
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
Etamsylate
T0002CAS 2624-44-4
Ethamsylate usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action...
Asapiprant
T5386CAS 932372-01-5
Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor.
TG4-155
T5482CAS 1164462-05-8
TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 μM) and a panel of other receptors and channe...
ETHYL CAFFEATE
T5681CAS 102-37-4
ETHYL CAFFEATE is a Cox-2, iNOS, NOS II, and PGE2 inhibitor,and have antiarthritic effect in collagen-induced arthritis (CIA) mice, its mechanism of action i...
7-demethylsuberosin
T5774CAS 21422-04-8
7-demethylsuberosin is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited inhibitory effects on PGE2 produc...
sphondin
T5758CAS 483-66-9
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
Travoprost
T5841CAS 157283-68-6
Travoprost is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
Cloprostenol sodium
T5847CAS 55028-72-3
Cloprostenol sodium is a more water solute, crystalline form of cloprostenol than the free acid, is a synthetic analog of prostaglandin F2α.
AM211
T7652CAS 1175526-27-8
Ipatasertib (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively.
E7046
TQ0025CAS 1369489-71-3
E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
Tafluprost
TQ0203CAS 209860-87-7
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.
ONO-AE3-208
TQ0290CAS 402473-54-5
ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
Grapiprant
TQ0292CAS 415903-37-6
Grapiprant (CJ-023423) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 2...
Anisotropine Methylbromide
T4981CAS 80-50-2
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
Ralinepag
T4635CAS 1187856-49-0
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP r...
Dazoxiben
T7968CAS 74226-22-5
Dazoxiben is a potent inhibitor of thromboxane (TX) synthase 
Tirucallol
TN1006CAS 514-46-5
Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.
1-Dehydro-6-gingerdione
TN1171CAS 76060-35-0
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
3-O-Acetyl-alpha-boswellic acid
TN1257CAS 89913-60-0
3-O-Acetyl-alpha-boswellic acid has strong anti-inflammatory activity.
Friedelin
TN1650CAS 559-74-0
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
Liriodendrin
TN1874CAS 573-44-4
Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
Pseudohypericin
TN2115CAS 55954-61-5
Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS.
Saikogenin D
TN2169CAS 5573-16-0
Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation o...
Epimagnolin B
TN1009CAS 1134188-26-3
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the ...
Taraxerol
TN1077CAS 127-22-0
Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
Handelin
TN1131CAS 62687-22-3
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
Afzelin
TN1362CAS 482-39-3
Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may prote...
Aromadendrin
TN1406CAS 480-20-6
Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear t...
Chicanine
TN1485CAS 78919-28-5
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
Continentalic acid
TN1524CAS 19889-23-7
Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis.
Ermanin
TN1622CAS 20869-95-8
Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent ac...
Beta-mangostin
TN1019CAS 20931-37-7
Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity