T0030 |
Bupivacaine hydrochloride |
Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membran...
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T0159 |
Pranoprofen |
Pranoprofen (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology. |
T0795 |
Rutin |
Rutin, a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties. |
T1626 |
Alprostadil |
Alprostadil is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that...
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T1978 |
GW 627368X |
GW627368X is a novel, potent and selective antagonist of prostanoid EP4 receptor. |
T2538 |
Bimatoprost |
Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension. |
T2786 |
Oxysophocarpine |
Oxysophocarpine is extracted from Sophra flavescens Ait. |
T2868 |
Evodiamine |
Evodiamine, an indole alkaloid found in Evodia rutaescarpa, acts as an anti-inflammatory compound. |
T3174 |
Taprenepag |
Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of...
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T3306 |
PF-04418948 |
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3,...
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T3889 |
Platycodin D |
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat perito...
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T3903 |
Angoroside C |
Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxida...
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T6485 |
Embelin |
Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM). |
T4546 |
Dinoprost Tromethamine |
Dinoprost(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. |
T7053 |
p-Hydroxy-cinnamic acid |
p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin ...
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T5014 |
Prostaglandin E2 (PGE2) |
Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dil...
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T5150 |
Treprostinil |
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM). |
T5171 |
Treprostinil Sodium |
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM). |
T0002 |
Etamsylate |
Ethamsylate usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action...
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T5386 |
Asapiprant |
Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor. |
T5482 |
TG4-155 |
TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 μM) and a panel of other receptors and channe...
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T5681 |
ETHYL CAFFEATE |
ETHYL CAFFEATE is a Cox-2, iNOS, NOS II, and PGE2 inhibitor,and have antiarthritic effect in collagen-induced arthritis (CIA) mice, its mechanism of action i...
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T5774 |
7-demethylsuberosin |
7-demethylsuberosin is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited inhibitory effects on PGE2 produc...
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T5758 |
sphondin |
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
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T5841 |
Travoprost |
Travoprost is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist. |
T5847 |
Cloprostenol sodium |
Cloprostenol sodium is a more water solute, crystalline form of cloprostenol than the free acid, is a synthetic analog of prostaglandin F2α. |
T7652 |
AM211 |
Ipatasertib (GDC-0068), a highly specific pan-Akt inhibitor, targets Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, respectively. |
TQ0025 |
E7046 |
E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities. |
TQ0203 |
Tafluprost |
Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α. |
TQ0290 |
ONO-AE3-208 |
ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer. |
TQ0292 |
Grapiprant |
Grapiprant (CJ-023423) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 2...
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T4981 |
Anisotropine Methylbromide |
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. |
T4635 |
Ralinepag |
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP r...
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T7968 |
Dazoxiben |
Dazoxiben is a potent inhibitor of thromboxane (TX) synthase |
TN1006 |
Tirucallol |
Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration. |
TN1171 |
1-Dehydro-6-gingerdione |
1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist. |
TN1257 |
3-O-Acetyl-alpha-boswellic acid |
3-O-Acetyl-alpha-boswellic acid has strong anti-inflammatory activity. |
TN1650 |
Friedelin |
Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. |
TN1874 |
Liriodendrin |
Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
|
TN2115 |
Pseudohypericin |
Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS. |
TN2169 |
Saikogenin D |
Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation o...
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TN1009 |
Epimagnolin B |
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the ...
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TN1077 |
Taraxerol |
Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic. |
TN1131 |
Handelin |
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions. |
TN1362 |
Afzelin |
Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may prote...
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TN1406 |
Aromadendrin |
Aromadendrin possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory activity through the suppression of nuclear t...
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TN1485 |
Chicanine |
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways. |
TN1524 |
Continentalic acid |
Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis. |
TN1622 |
Ermanin |
Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent ac...
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TN1019 |
Beta-mangostin |
Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity |
TN1109 |
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid |
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264....
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TN1134 |
Euscaphic acid |
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 ...
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TN1140 |
Onjisaponin B |
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±...
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TN1238 |
3,4-O-Isopropylidene shikimic acid |
3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimen...
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TN1378 |
alpha-Viniferin |
Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities. |
TN1440 |
Beta-Hydroxyisovalerylshikonin |
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in...
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TN2091 |
Polygalacin D |
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
|
T12100 |
mPGES1-IN-3 |
mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) . |
T10046 |
16,16-Dimethyl prostaglandin E2 |
16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an in...
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T13488 |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer. It can maintain the content of phospholipase A2 and pro...
|
T14139 |
Aganepag |
Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM. It shows no activity at EP4 receptor. Aganepag can be used in the research of wou...
|
T14146 |
AGN 210676 |
AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM). |
T14500 |
BAY-1316957 |
BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1]. |
T11211 |
EP4 receptor antagonist 1 |
EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM and 16.2 nM, respectively. IC50s >10 μM for human EP1, EP2,and EP3 rece...
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T11340 |
Furprofen |
Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain. Furprofen is an non-steroidal anti...
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T15642 |
KAG-308 |
KAG-308 is an effective selective and orally active agonist of EP4 receptor. KAG-308 displays a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, resp...
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T15681 |
L-161982 |
L-161982 is a selective EP4 receptor antagonist. L-161982 decreases collagen-induced arthritis in mice. L-161982 fully blocks PGE2-induced ERK phosphorylation a...
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T15689 |
L-798106 |
L-798106 is an effective and highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (...
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T15690 |
L-902688 |
L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors. L-902688 is a selective and orally active EP4 receptor agonist (Ki: 0.38...
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T10668 |
Camalexin |
Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce R...
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T13466 |
(+)-Talarozole |
(+)-Talarozole is a potent retinoic acid metabolism inhibitor . |
T16011 |
Manumycin A |
Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted in...
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T16388 |
Omidenepag isopropyl |
Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidene...
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T16389 |
Omidenepag |
Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag display...
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T16504 |
PF-4693627 |
PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by ost...
|
T16988 |
Taprenepag isopropyl |
Taprenepag isopropyl is a highly selective agonist of the EP2 receptor. |
T17092 |
Tiaprost |
Tiaprost is a analog of prostaglandin F2α . |
T2S0765 |
Epibetulinic acid |
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7)...
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T3P2855 |
Chamigrenal |
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7...
|
T4484 |
1,7-Dihydroxy-2,3-methylenedioxyxanthone |
1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalges...
|
TMA0536 |
2-Acetylbenzoic acid |
2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the poten...
|
TN3144 |
6,4'-Dihydroxy-7-methoxyflavanone |
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
|
TN3366 |
Ailanthoidol |
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
|
TN3582 |
Canniprene |
Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and al...
|
TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
|
TMA0291 |
Dehydroglyasperin D |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 ...
|
TN3839 |
Desoxo-narchinol A |
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity again...
|
TN4038 |
Eupatolide |
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
|
TN4046 |
Excisanin A |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pot...
|
TN4062 |
Flavidin |
Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it shoul...
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TN4064 |
Flavoglaucin |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
|
TN4162 |
Goshonoside F5 |
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo. |
TN4194 |
Heliangin |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 ce...
|
TN4303 |
Isokaempferide |
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by re...
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TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
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TN4463 |
Lupeolic acid |
Lupeolic acid has anti-inflammatory activity. |
TN4465 |
Luvangetin |
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection again...
|
TN4489 |
Manassantin A |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
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TN4592 |
Murrangatin |
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hi...
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TN4635 |
Neoechinulin A |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
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TN4675 |
Nortrachelogenin |
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
|
TN4748 |
Penduletin |
Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendul...
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TN4879 |
Questinol |
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit t...
|
TMA1570 |
Sappanone A |
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
|
TN4959 |
Schizandriside |
Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysa...
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TN5011 |
Shizukaol B |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
|
TN5017 |
Sideritoflavone |
Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro. |
TN5019 |
Siegeskaurolic acid |
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages vi...
|
TN5033 |
Skullcapflavone I |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages an...
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TN5248 |
Voleneol |
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depend...
|