Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2. They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.

Cat No.	product name
T0030	Bupivacaine hydrochloride	Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivacaine reversibly binds to specific sodium ion channels in the neuronal membran...
T0159	Pranoprofen	Pranoprofen (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
T0795	Rutin	Rutin, a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
T1626	Alprostadil	Alprostadil is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that...
T1978	GW 627368X	GW627368X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
T2538	Bimatoprost	Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
T2786	Oxysophocarpine	Oxysophocarpine is extracted from Sophra flavescens Ait.
T2868	Evodiamine	Evodiamine, an indole alkaloid found in Evodia rutaescarpa, acts as an anti-inflammatory compound.
T3174	Taprenepag	Taprenepag (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of...
T3306	PF04418948	PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3,...
T3889	Platycodin D	Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat perito...
T3903	Angoroside C	Angoroside C is a Potential anti-inflammatory compound. Inhibitor of prostaglandin E2 release in mouse peritoneal macrophages in vitro. Shows potent antioxida...
T6485	Embelin	Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T4546	Dinoprost Tromethamine	Dinoprost(Prostaglandin F2α) tromethamine salt is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
T7053	p-Hydroxy-cinnamic acid	p-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin ...
T5014	Prostaglandin E2 (PGE2)	Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dil...
T5150	Treprostinil	Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T5171	Treprostinil Sodium	Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T0002	Ethamsylate	Ethamsylate usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action o...
T5386	Asapiprant	Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor.
T5482	TG4-155	TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channe...
T5681	ETHYL CAFFEATE	In vitro, ECF suppressed the differentiation of naive CD4+ T cells into Th1. Furthermore, ECF intensely blocked the transcriptional expression in interferon-γ-...
T5774	7-demethylsuberosin	7-demethylsuberosin is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited inhibitory effects on PGE2 pro...
T5758	sphondin	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level o...
T5841	Travoprost	Travoprost is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
T5847	Cloprostenol sodium	Cloprostenol sodium is a more water solute, crystalline form of cloprostenol than the free acid, is a synthetic analog of prostaglandin F2α.
T7652	AM211	AM211 is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)
TQ0025	E7046	E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
TQ0203	Tafluprost	Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.
TQ0290	ONO-AE3-208	ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
TQ0292	Grapiprant	Grapiprant (CJ-023423) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 2...
T4981	Anisotropine Methylbromide	Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
T4635	Ralinepag	Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP r...
T7968	Dazoxiben	Dazoxiben is a potent inhibitor of thromboxane (TX) synthase
TN1006	Tirucallol	Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action r...
TN1171	1-Dehydro-6-gingerdione	1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
TN1257	3-O-Acetyl-alpha-boswellic acid	3-O-Acetyl-alpha-boswellic acid has strong anti-inflammatory activity.
TN1650	Friedelin	Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.
TN1874	Liriodendrin	Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities, it plays protective role in sepsis-induced acute lung injury, it regulates lung in...
TN2115	Pseudohypericin	Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS.
TN2169	Saikogenin D	Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation o...
TN1009	Epimagnolin B	Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the ...
TN1077	Taraxerol	Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic.
TN1131	Handelin	Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
TN1362	Afzelin	Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may prote...
TN1406	Aromadendrin	Aromadendrin is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic ...
TN1485	Chicanine	Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
TN1524	Continentalic acid	Continentalic acid and kaurenoic acid are quality control markers in Aralia continentalis.
TN1622	Ermanin	Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent ac...
TN1019	Beta-mangostin	Beta-mangostin has cytotoxic, and anti-inflammatory effects, it exhibits strong antibacterial activity
TN1109	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264....
TN1134	Euscaphic acid	Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 ...
TN1140	Onjisaponin B	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±...
TN1238	3,4-O-Isopropylidene shikimic acid	3,4-Oxo- isopropylidene-shikimic acid has significant anti-inflammatory, anti-thrombosis, antioxidant, analgesic effects, it has protective effects on experimen...
TN1378	alpha-Viniferin	Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities.
TN1440	Beta-Hydroxyisovalerylshikonin	Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in...
TN2091	Polygalacin D	Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNO...
T12100	mPGES1-IN-3	mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .
T10046	16,16-Dimethyl prostaglandin E2	16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an in...
T13488	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer. It can maintain the content of phospholipase A2 and pro...
T14139	Aganepag	Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM. It shows no activity at EP4 receptor. Aganepag can be used in the research of wou...
T14146	AGN 210676	AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).
T14500	BAY-1316957	BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].
T11211	EP4 receptor antagonist 1	EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM and 16.2 nM, respectively. IC50s >10 μM for human EP1, EP2,and EP3 recept...
T11340	Furprofen	Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain. Furprofen is an non-steroidal anti...
T15642	KAG-308	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, E...
T15681	L-161982	L-161982 is a selective EP4 receptor antagonist. L-161982 decreases collagen-induced arthritis in mice. L-161982 fully blocks PGE2-induced ERK phosphorylation a...
T15689	L-798106	L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >50...
T15690	L-902688	L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid rece...
T10668	Camalexin	Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce R...
T13466	(+)-Talarozole	(+)-Talarozole is a potent retinoic acid metabolism inhibitor .
T16011	Manumycin A	Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted in...
T16388	Omidenepag isopropyl	Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidene...
T16389	Omidenepag	Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag display...
T16504	PF-4693627	PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by ost...
T16988	Taprenepag isopropyl	Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.
T17092	Tiaprost	Tiaprost is a analog of prostaglandin F2α .
T2S0765	Epibetulinic acid	Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7)...
T3P2855	Chamigrenal	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7...
T4484	1,7-Dihydroxy-2,3-methylenedioxyxanthone	1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalges...
TMA0536	2-Acetylbenzoic acid	2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the poten...
TN3144	6,4'-Dihydroxy-7-methoxyflavanone	6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
TN3366	Ailanthoidol	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
TN3582	Canniprene	Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and al...
TN3587	Capillarisin	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
TMA0291	Dehydroglyasperin D	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 ...
TN3839	Desoxo-narchinol A	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity again...
TN4038	Eupatolide	Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradatio...
TN4046	Excisanin A	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pot...
TN4062	Flavidin	Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it shoul...
TN4064	Flavoglaucin	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
TN4162	Goshonoside F5	Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4194	Heliangin	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 ce...
TN4303	Isokaempferide	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by re...
TN4420	Latifolin	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
TN4463	Lupeolic acid	Lupeolic acid has anti-inflammatory activity.
TN4465	Luvangetin	Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection again...
TN4489	Manassantin A	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effe...
TN4592	Murrangatin	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hi...
TN4635	Neoechinulin A	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block t...
TN4675	Nortrachelogenin	Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
TN4748	Penduletin	Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendul...
TN4879	Questinol	Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit t...
TMA1570	Sappanone A	Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
TN4959	Schizandriside	Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysa...
TN5011	Shizukaol B	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
TN5017	Sideritoflavone	Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro.
TN5019	Siegeskaurolic acid	Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages vi...
TN5033	Skullcapflavone I	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages an...
TN5248	Voleneol	1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-depend...
T14865	Carboprost tromethamine	Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F2α and it can effectively promote law contraction of the uterus and significantly...
T3S2007	MRE269	MRE-269 is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269 is used for the treatment of pulmonary arterial hypertension. MRE-...
T3276	Benorilate	Benorylate is the esterification product of paracetamol and acetylsalicylic acid with anti-inflammatory, analgesic and antipyretic properties.
T15259	Evatanepag	Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability...
T15259	Evatanepag	Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability...