Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, , PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.

Cat. No.	Product name	CAS No.	Purity
T15259	Evatanepag	223488-57-1	99.68%
T15259	Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 dem...
T10098	PGS-IN-1	102271-49-8	99.67%
T10098	PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).
T17039	Terbogrel	149979-74-8	99.65%
T17039	Terbogrel is an oral thromboxane A2 receptor antagonist (IC50 is about 10 nM) and thromboxane A2 synthase inhibitor (IC50 is about 10 nM). Terbogrel is an antipl...
T14865	Carboprost tromethamine	58551-69-2	99.61%
T14865	Carboprost tromethamine, a synthetic 15-methyl analogue of prostaglandin F2α, effectively promotes uterine contractions and significantly reduces bleeding during...
T67946	EP2 receptor antagonist-2	615273-95-5	99.59%
T67946	EP2 receptor antagonist-2 (CID891729) is a compound that not only serves as an antagonist to the EP2 receptor, blocking its activation by PGE2, but also reduces ...
TN1440	Beta-Hydroxyisovalerylshikonin	7415-78-3	99.59%
TN1440	Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor ...
T3S2007	MRE-269	475085-57-5	99.57%
T3S2007	MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary art...
TMA0536	2-Acetylbenzoic acid	577-56-0	99.57%
TMA0536	2-Acetylbenzoic acid is more potent than 2-propionyloxybenzoic acid in inhibiting platelet function and platelet prostaglandin (PG) synthesis although the potenc...
T2690	Tranilast	53902-12-8	99.57%
T2690	Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of aller...
T21224	(+)-Fluprostenol	54276-17-4	99.56%
T21224	(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycop...
T62061	COX-2-IN-6	2756347-91-6	99.56%
T62061	COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-dr...
T7053	P-Hydroxycinnamic acid	7400-08-0	99.55%
T7053	p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prost...
T0212	Seratrodast	112665-43-7	99.54%
T0212	Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor ant...
T6399	AZD1981	802904-66-1	99.54%
T6399	AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors,...
T1978	GW627368	439288-66-1	99.54%
T1978	GW627368 (GW 627368X)X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
T11211	EP4 receptor antagonist 1	2287259-07-6	99.53%
T11211	EP4 Receptor Antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist, effective for cancer immunotherapy. It inhibits both h...
T68155	Tebufelone	112018-00-5	99.52%
T68155	Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has...
TQ0292	Grapiprant	415903-37-6	99.49%
TQ0292	Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 n...
T24567	Octimibate	89838-96-0	99.49%
T24567	Octimibate (Octimibato) is a non-prostaglandin platelet aggregation inhibitor and cyclic prostaglandin agonist.Octimibate is used in the treatment of cardiovascu...
T2791	Pectolinarin	28978-02-1	99.47%
T2791	Pectolinarin is a Cirsium isolate with anti-inflammatory activity.