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Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, , PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3965 Fevipiprant 872365-14-5 98%
Fevipiprant
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
T0159 Pranoprofen 52549-17-4 97.99%
Pranoprofen
Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
T28089 MPGES-1 Inhibitor-1 1381846-21-4 97.90%
mPGES-1 Inhibitor-1
mPGES-1 Inhibitor-1 is a novel selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with anti-inflammatory and analgesic activity for the study...
T21976 ONO-8130 459841-96-4 97.82%
ONO-8130
ONO-8130 is an orally available antagonist of EP1 receptor.
T21738 PF-9184 1221971-47-6 97.64%
PF-9184
PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesi...
T14148 AH 6809 33458-93-4 97.59%
AH 6809
AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). A...
T6485 Embelin 550-24-3 97.07%
Embelin
Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T27630 Isbogrel 89667-40-3 97.06%
Isbogrel
Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks...
T10960L Darbufelone mesylate 139340-56-0 96.81%
Darbufelone mesylate
Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 ...
T27084 Crisdesalazine 927685-43-6 95.95%
Crisdesalazine
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and mo...
T16280 Nedocromil 69049-73-6 95%
Nedocromil
Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
T0795 Rutin 153-18-4 95%
Rutin
Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarci...
T13563 AZ-1355 75451-07-9 100%
AZ-1355
AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.
T77699 EP4-IN-1 2455480-28-9 100%
EP4-IN-1
EP4-IN-1 is a potent prostaglandin EP4 receptor inhibitor with potential anti-tumor, anti-inflammatory and analgesic activities for the study of immune and tumor...
TN1257 3-O-Acetyl-α-boswellic acid 89913-60-0 100%
3-O-Acetyl-α-boswellic acid
3-O-Acetyl-α-boswellic acid (α-Boswellic acid acetate) has strong anti-inflammatory activity.
T2428 TG6-10-1 1415716-58-3 100%
TG6-10-1
TG6-10-1 is an EP2 antagonist.
T63667 ONO-8713 459411-08-6 100%
ONO-8713
ONO-8713 is a selective prostaglandin E receptor subtype EP1 antagonist that can be used to study diseases of the biblical system and metabolism-related diseases...
T5841 Travoprost 157283-68-6 100%
Travoprost
Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
T6236 Ozagrel 82571-53-7 100%
Ozagrel
Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative...
T4635 Ralinepag 1187856-49-0
Ralinepag
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and r...
Fevipiprant
T3965
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
Pranoprofen
T0159
Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.
mPGES-1 Inhibitor-1
T28089
mPGES-1 Inhibitor-1 is a novel selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with anti-inflammatory and analgesic activity for the study...
ONO-8130
T21976
ONO-8130 is an orally available antagonist of EP1 receptor.
PF-9184
T21738
PF-9184 is a potent and selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), IC50 =16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesi...
AH 6809
T14148
AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). A...
Embelin
T6485
Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
Isbogrel
T27630
Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks...
Darbufelone mesylate
T10960L
Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 ...
Crisdesalazine
T27084
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and mo...
Nedocromil
T16280
Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
Rutin
T0795
Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarci...
AZ-1355
T13563
AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.
EP4-IN-1
T77699
EP4-IN-1 is a potent prostaglandin EP4 receptor inhibitor with potential anti-tumor, anti-inflammatory and analgesic activities for the study of immune and tumor...
3-O-Acetyl-α-boswellic acid
TN1257
3-O-Acetyl-α-boswellic acid (α-Boswellic acid acetate) has strong anti-inflammatory activity.
TG6-10-1
T2428
TG6-10-1 is an EP2 antagonist.
ONO-8713
T63667
ONO-8713 is a selective prostaglandin E receptor subtype EP1 antagonist that can be used to study diseases of the biblical system and metabolism-related diseases...
Travoprost
T5841
Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
Ozagrel
T6236
Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative...
Ralinepag
T4635
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and r...
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TargetMol