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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones Enzyme GPCR/G Protein Immunology / Inflammation JAK/STAT signaling
MAPK Membrane transporter/Ion channel Metabolism Microbiology&virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries Approved / Repurposing Characteristic Bioactive Libraries COVID-19 / SARS-CoV-2 Disease Focused Target / Pathway Focused Natural Product Libraries Characteristic Natural Product Libraries Natural Compound Library for HTS Fragment Libraries Diversity Sets Custom Compound Library
Signaling pathway Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones Enzyme GPCR/G Protein Immunology / Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology&virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling
Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Focused Bioactive Libraries Approved / Repurposing Characteristic Bioactive Libraries COVID-19 / SARS-CoV-2 Disease Focused Target / Pathway Focused
Natural Product Libraries Characteristic Natural Product Libraries Natural Compound Library for HTS Diversity Sets Golden Scaffold Library Mini Scaffold Library
Fragment Libraries Drug-fragment Library Featured Fragment Library High Solubility Fragment Library Custom Compound Library
GPCR/G Protein Protease-activated Receptor

Protease-activated Receptor

Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, and also on endothelial cells, myocytes and neurons.
Cat No. product name
T1893 ML 161 ML 161 is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expressio...
T1986L Atopaxar Hydrobromide Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Arte...
T3098 Vorapaxar sulfate Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
T4186 AC-264613 AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 pr...
T7013 Vorapaxar Vorapaxar (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
T7137 I-191 I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.
T7380 Protease-Activated Receptor-4 Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4) agonist, with Antiplatelet Therapy
T7496 Thrombin Receptor Activator for Peptide Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
T7573 TFLLR-NH2(2TFA) TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
T7623 PAR-4 Agonist Peptide, amide(2TFA) PAR-4 Agonist Peptide, amide(2TFA) is an agonist of proteinase-activated receptor-4 (PAR-4).
T7625 TRAP-6(2TFA) TRAP-6(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
T7674 Thrombin Receptor Activator for Peptide Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
T7740 Protease-Activated Receptor-4 diTFA(245443-52-1(free base)) Protease-Activated Receptor-4 diTFA，2454 is the proteinase-activated receptor-4 (PAR4)agonist
TQ0012 AZ3451 AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
ML 161
T1893CAS 423735-93-7
ML 161 is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expressio...
Atopaxar Hydrobromide
T1986LCAS 474550-69-1
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Arte...
Vorapaxar sulfate
T3098CAS 705260-08-8
Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
AC-264613
T4186CAS 1051487-82-1
AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 pr...
Vorapaxar
T7013CAS 618385-01-6
Vorapaxar (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
I-191
T7137CAS 1690172-25-8
I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.
Protease-Activated Receptor-4
T7380CAS 245443-52-1
Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4) agonist, with Antiplatelet Therapy
Thrombin Receptor Activator for Peptide
T7496CAS 141685-53-2
Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
TFLLR-NH2(2TFA)
T7573CAS 197794-83-5
TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
PAR-4 Agonist Peptide, amide(2TFA)
T7623CAS 352017-71-1
PAR-4 Agonist Peptide, amide(2TFA) is an agonist of proteinase-activated receptor-4 (PAR-4).
TRAP-6(2TFA)
T7625CAS 141136-83-6
TRAP-6(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
Thrombin Receptor Activator for Peptide
T7674CAS T7674
Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
Protease-Activated Receptor-4 diTFA(245443-52-1(free base))
T7740CAS T7740
Protease-Activated Receptor-4 diTFA，2454 is the proteinase-activated receptor-4 (PAR4)agonist
AZ3451
TQ0012CAS 2100284-59-9
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
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