Protease-activated Receptor

Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, and also on endothelial cells, myocytes and neurons.

Cat No.	product name
T1893	ML 161	ML 161 is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expressio...
T1986L	Atopaxar Hydrobromide	Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Arte...
T3098	Vorapaxar sulfate	Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
T4186	AC264613	AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 pr...
T7013	Vorapaxar	Vorapaxar (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).
T7137	I-191	I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.
T7496	Thrombin Receptor Activator for Peptide	Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
T7380	Protease-Activated Receptor-4	Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4) agonist, with Antiplatelet Therapy
T7674	Thrombin Receptor Activator for Peptide	Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of co...
TQ0012	AZ3451	AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
T7573	TFLLR-NH2(2TFA)	TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
T7623	PAR-4 Agonist Peptide, amide	PAR-4 Agonist Peptide, amide is an agonist of proteinase-activated receptor-4 (PAR-4).
T7625	TRAP-6(2TFA)	TRAP-6(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
T7740	Protease-Activated Receptor-4 diTFA(245443-52-1(free base))	Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist
T7573L	TFLLR-NH2 2TFA(197794-83-5(free base))	TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
T7513	Protease-Activated Receptor-2, amide	Protease-Activated Receptor-2, amide is an agonist of PAR2 (IC50 : 10.4 M)
TP1925L	tcY-NH2 TFA(327177-34-4 free base)	tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
TP1904L	FSLLRY-NH2 TFA(245329-02-6 free base)	FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in I...
TP1378	2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)	2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist.
TP1046L	PAR-2 Activating Peptide acetate(171436-38-7 free base)	PAR-2 Activating Peptide acetate is an agonist of Protease-Activated Receptor-2 (PAR-2).
TP1046L	PAR-2 Activating Peptide acetate(171436-38-7 free base)	PAR-2 Activating Peptide acetate is an agonist of Protease-Activated Receptor-2 (PAR-2).
TP1065	PAR-4 Agonist Peptide, amide TFA	PAR-4 Agonist Peptide, amide TFA is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocke...