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Protease-activated Receptor

Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, and also on endothelial cells, myocytes and neurons.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1986L Atopaxar Hydrobromide 474550-69-1 100%
Atopaxar Hydrobromide
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Arter...
T7573L TFLLR-NH2 2TFA(197794-83-5(free base)) T7573L 100%
TFLLR-NH2 2TFA(197794-83-5(free base))
TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
TP1378 2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) TP1378 100%
2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.
TP1925L TcY-NH2 TFA(327177-34-4 free base) TP1925L 100%
tcY-NH2 TFA(327177-34-4 free base)
tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
T7625 TRAP-6 141136-83-6 100%
TRAP-6
TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
TP1065 PAR-4 Agonist Peptide, amide TFA 1228078-65-6 100%
PAR-4 Agonist Peptide, amide TFA
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose ef...
T7623 PAR-4 Agonist Peptide, amide 352017-71-1
PAR-4 Agonist Peptide, amide
PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).
TP1904L FSLLRY-NH2 TFA(245329-02-6 free base) TP1904L
FSLLRY-NH2 TFA(245329-02-6 free base)
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR...
T22933L LRGILS-NH2 acetate 98%
LRGILS-NH2 acetate
LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.
T27267 ENMD-1068 HCl 789488-77-3 98%
ENMD-1068 HCl
ENMD-1068 HCl (ENMD 1068) is a PAR-2 antagonist. ENMD-1068 HCl inhibits the development of endometriosis in a mouse model.
TP1046 SLIGRL-NH2 171436-38-7 98%
SLIGRL-NH2
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a protease-activated receptor-2 (PAR-2) agonist that induces non-histaminergic pruritus.
TN6872 Trypsin 9002-07-7 98%
Trypsin
Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin c...
T7674 Thrombin Receptor Activator for Peptide T7674 98%
Thrombin Receptor Activator for Peptide
Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of cor...
T1893 Parmodulin 2 423735-93-7 98%
Parmodulin 2
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selec...
T7513 Protease-Activated Receptor-2, amide 190383-13-2 98%
Protease-Activated Receptor-2, amide
Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)
Atopaxar Hydrobromide
T1986L
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling. Atopaxar has been investigated for the treatment of Coronary Arter...
TFLLR-NH2 2TFA(197794-83-5(free base))
T7573L
TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).
2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
TP1378
2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.
tcY-NH2 TFA(327177-34-4 free base)
TP1925L
tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
TRAP-6
T7625
TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
PAR-4 Agonist Peptide, amide TFA
TP1065
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose ef...
PAR-4 Agonist Peptide, amide
T7623
PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).
FSLLRY-NH2 TFA(245329-02-6 free base)
TP1904L
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR...
LRGILS-NH2 acetate
T22933L
LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.
ENMD-1068 HCl
T27267
ENMD-1068 HCl (ENMD 1068) is a PAR-2 antagonist. ENMD-1068 HCl inhibits the development of endometriosis in a mouse model.
SLIGRL-NH2
TP1046
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a protease-activated receptor-2 (PAR-2) agonist that induces non-histaminergic pruritus.
Trypsin
TN6872
Trypsin is a serine protease that can be isolated from fish to hydrolyze lysine or arginine carboxy-side proteins. With the anti-inflammatory activity, Trypsin c...
Thrombin Receptor Activator for Peptide
T7674
Thrombin Receptor Activator for Peptide is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of cor...
Parmodulin 2
T1893
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selec...
Protease-Activated Receptor-2, amide
T7513
Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)
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TargetMol