Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.

Cat. No.	Product name	CAS No.	Purity
T21510	PSI	158442-41-2	98%
T21510	PSI is a proteasome inhibitor.
TP1961L	PR 39 (porcine) acetate		98%
TP1961L	PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor. PR 39 (porcine) acetate reversibly binds to the α7 subunit of the pr...
T16684	Puromycin aminonucleoside	58-60-6	99.97%
T16684	Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.
T6203	Saxagliptin	361442-04-8	99.95%
T6203	Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
T4042	Talabostat mesylate	150080-09-4	99.91%
T4042	Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast act...
T6830	Epoxomicin	134381-21-8	99.91%
T6830	Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome,...
T12579	RAMB4	145888-79-5	99.88%
T12579	RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.
T7917	4'-Hydroxychalcone	2657-25-2	99.86%
T7917	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity
T2745	18α-Glycyrrhetinic acid	1449-05-4	99.83%
T2745	18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation fact...
T0178	Saxagliptin hydrate	945667-22-1	99.8%
T0178	Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).
T1674	Nateglinide	105816-04-4	99.78%
T1674	Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy ...
T6192	Alogliptin	850649-61-5	99.77%
T6192	Alogliptin (SYR-322)(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9....
T2316	Omarigliptin	1226781-44-7	99.70%
T2316	Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.
T63321	20S Proteasome activator 1	2761578-18-9	99.68%
T63321	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase si...
T0242L	Sitagliptin phosphate monohydrate	654671-77-9	99.65%
T0242L	Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
T15079	DBPR108	1186426-66-3	99.65%
T15079	DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.
T0372	Gabexate mesylate	56974-61-9	99.64%
T0372	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and...
T7016	VR23	1624602-30-7	99.62%
T7016	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for ca...
T1795	Carfilzomib	868540-17-4	99.6%
T1795	Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be u...
T8550	NDMC101	1308631-40-4	99.59%
T8550	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 a...