Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.

Cat. No.	Product name	CAS No.	Purity
T63321	20S Proteasome activator 1	2761578-18-9	99.68%
T63321	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase si...
T0242L	Sitagliptin phosphate monohydrate	654671-77-9	99.65%
T0242L	Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
T15079	DBPR108	1186426-66-3	99.65%
T15079	DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.
T0372	Gabexate mesylate	56974-61-9	99.64%
T0372	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and...
T7016	VR23	1624602-30-7	99.62%
T7016	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for ca...
T8550	NDMC101	1308631-40-4	99.59%
T8550	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 a...
T13247	UK-101	1000313-40-5	99.58%
T13247	UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM....
T4467	UAMC00039 dihydrochloride	697797-51-6	99.56%
T4467	UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.
T3028	Tripterin	34157-83-0	99.48%
T3028	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripter...
T8978	DD1	187585-11-1	99.46%
T8978	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.
T6027	Delanzomib	847499-27-8	99.46%
T6027	Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and ...
T36583	Gly-Pro-pNA hydrochloride	103213-34-9	99.41%
T36583	Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase ...
T0242	Sitagliptin	486460-32-6	99.4%
T0242	Sitagliptin (MK0431), a new oral hypoglycemic (anti-diabetic drug), is a new dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme-inhibiting drug is used either...
T1176	Racecadotril	81110-73-8	99.39%
T1176	Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
T2370	AC-55541	916170-19-9	99.35%
T2370	AC-55541 (AOB2796) is a novel PAR2 agonist; activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobiliz...
T9090	MUN57694	858557-69-4	99.24%
T9090	MUN57694 is an inhibitor of 26S proteasome.
TQ0038	Brensocatib	1802148-05-5	99.05%
TQ0038	Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).
T6041	Oprozomib	935888-69-0	99.05%
T6041	Oprozomib (PR-047) (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome β5(IC50=36 nM)/LMP7(IC50=82 nM), is orally bioavailable. Oprozomib also has pote...
T2583	Cilastatin	82009-34-5	99.03%
T2583	Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, ...
T12710	Retagliptin Phosphate	1256756-88-3	98.97%
T12710	Retagliptin Phosphate (SP 2086) is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes.