RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.

Cat. No.	Product name	CAS No.	Purity
T11501	GSK840	2361146-30-5	99.48%
T11501	GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase act...
T79600	Zharp2-1	2772600-18-5	99.41%
T79600	Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-i...
T4074	GSK-872	1346546-69-7	99.3%
T4074	GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activ...
T9305	Necroptosis-IN-1	1391980-92-9	99.26%
T9305	Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
T8931L	ICCB-19 hydrochloride	1803605-68-6	99.23%
T8931L	ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain ...
T11474	GSK-843	1601496-05-2	99.18%
T11474	GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase.GSK-843 has potential analgesic ...
T9072	Tuxobertinib	2414572-47-5	98.86%
T9072	Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK a...
T63055	RIPK1-IN-9	2682889-57-0	98.75%
T63055	RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respect...
T3537	GSK583	1346547-00-9	98.68%
T3537	GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T11492	GSK2983559 free acid	1579965-12-0	98.61%
T11492	GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
T5401	GSK2983559 active metabolite	1423186-80-4	98.48%
T5401	GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
T24152	HTH-01-091	2000209-42-5	98.40%
T24152	HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T12728	RIP2 Kinase Inhibitor 3	1398053-50-3	98.35%
T12728	RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
T12493	PK68	2173556-69-7	98.13%
T12493	PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
T37558	Necrostatin-5	337349-54-9	98.03%
T37558	Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with T...
T12731	RIPK1-IN-7	2300982-44-7	98.02%
T12731	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...
T6815	HS-1371	2158197-70-5	98%
T6815	HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
T5054	GSK963	2049868-46-2	97.45%
T5054	GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
T9095	Necrostatin-34	375835-43-1	97%
T9095	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distin...
T7795	RIPA-56	1956370-21-0	100%
T7795	RIPA-56 is an inhibitor of RIP1