Home Tools
Log in
Cart

ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4276L Hydroxyfasudil 105628-72-6 98.79%
Hydroxyfasudil
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
T2155 Thiazovivin 1226056-71-8 98.75%
Thiazovivin
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
T3518 GSK269962A 850664-21-0 98.63%
GSK269962A
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T4488 GSK-25 874119-56-9 98.59%
GSK-25
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
T11402L GKI-1 HCl T11402L 98.44%
GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
T2633 GSK429286A 864082-47-3 98.42%
GSK429286A
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T35328 H-1152 dihydrochloride 871543-07-6 98.42%
H-1152 dihydrochloride
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochlo...
T38654 Cotosudil 1258833-31-6 98.41%
Cotosudil
Cotosudil is a ROCK kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or...
T14989 CMPD101 865608-11-3 98.34%
CMPD101
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
T26078 Rhodblock 6 886625-06-5 98.27%
Rhodblock 6
Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits the localization of phosphorylated MRLC (Myosin Regulatory Light Chain) and acts by specifically inhib...
T3513 GSK180736A 817194-38-0 98.16%
GSK180736A
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
T77609 WAY-656935 852902-81-9 98.1%
WAY-656935
WAY-656935 inhibits ROCK.
T23308 SAR407899 hydrochloride 923262-96-8 98.01%
SAR407899 hydrochloride
ATP-competitive ROCK inhibitor
T7301 BDP5290 1817698-21-7 98%
BDP5290
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
TQ0110 ROCK-IN-2 867017-68-3 97.59%
ROCK-IN-2
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
T10888 CRT0066854 hydrochloride 2250019-91-9 97.51%
CRT0066854 hydrochloride
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
T6867 Belumosudil 911417-87-3 97.41%
Belumosudil
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
T9652 SB-747651A Dihydrochloride 1781882-72-1 97.02%
SB-747651A Dihydrochloride
SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC 50 of 11 nM. SB-747651A dihydrochloride also ...
T19913 CKI-7 1177141-67-1 100.00%
CKI-7
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
T13419 ROCK-IN-1 934387-35-6 100%
ROCK-IN-1
ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological disor...
Hydroxyfasudil
T4276L
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
Thiazovivin
T2155
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
GSK269962A
T3518
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
GSK-25
T4488
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
GKI-1 HCl
T11402L
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
GSK429286A
T2633
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
H-1152 dihydrochloride
T35328
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochlo...
Cotosudil
T38654
Cotosudil is a ROCK kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or...
CMPD101
T14989
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
Rhodblock 6
T26078
Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits the localization of phosphorylated MRLC (Myosin Regulatory Light Chain) and acts by specifically inhib...
GSK180736A
T3513
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
WAY-656935
T77609
WAY-656935 inhibits ROCK.
SAR407899 hydrochloride
T23308
ATP-competitive ROCK inhibitor
BDP5290
T7301
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
ROCK-IN-2
TQ0110
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
CRT0066854 hydrochloride
T10888
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
Belumosudil
T6867
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
SB-747651A Dihydrochloride
T9652
SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC 50 of 11 nM. SB-747651A dihydrochloride also ...
CKI-7
T19913
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
ROCK-IN-1
T13419
ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological disor...
1 2 3 4
TargetMol