Raf

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma. RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires interaction with RAS-GTPases.

Cat. No.	Product name	CAS No.	Purity
T3711	RAF709	1628838-42-5	99.43%
T3711	RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.
T8745	PROTAC BRAF-V600E degrader-1	2417296-84-3	99.43%
T8745	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
T9693	TBAP-001	1777832-90-2	99.3%
T9693	TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.
T63644	Exarafenib	2639957-39-2	99.26%
T63644	Exarafenib (RAF/KIN_2787) is a potent and orally available pan-RAF inhibitor.Exarafenib has antitumor activity and acts by inhibiting downstream MAPK pathway sig...
T1892	Kobe2602	454453-49-7	99.24%
T1892	Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
T2070	Agerafenib	1188910-76-0	99.23%
T2070	Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.
T0093	Sorafenib tosylate	475207-59-1	99.2%
T0093	Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T6296	RAF265	927880-90-8	99.18%
T6296	RAF265 (CHIR-265) (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphoryl...
T6052	GW 441756	504433-23-2	98.99%
T6052	GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
TP2358	KRPEP-2D acetate	TP2358	98.94%
TP2358	KRPEP-2D acetate was identified as a K-Ras(G12D) selective inhibitory peptide against the G12D mutant of K-Ras, which is a key member of the Ras protein family a...
T1886	TAK-632	1228591-30-7	98.92%
T1886	TAK-632 is a potent pan-Raf inhibitor.
T6003	GSK1904529A	1089283-49-7	98.89%
T6003	GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T60029	SOS1-IN-11	2654741-64-5	98.79%
T60029	SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).
T2074	Raf inhibitor 1	1093100-40-3	98.78%
T2074	B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.
T9585	GNE-9815	2729996-45-4	98.73%
T9585	GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective inhib...
T5469	K-Ras-IN-1	84783-01-7	98.72%
T5469	K-Ras-IN-1 is a K-Ras inhibitor.
T11224	Rineterkib	1715025-32-3	98.4%
T11224	Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
T9755	MRTX0902	2654743-22-1	98.37%
T9755	MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.
T2327	Pelitinib	257933-82-7	98.37%
T2327	Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
T6556	K-Ras(G12C) inhibitor 9	1469337-91-4	98.31%
T6556	K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).