T3579 |
PLX8394
|
1393466-87-9
|
100%
|
|
PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both w...
|
T5634 |
Belvarafenib
|
1446113-23-0
|
|
|
Belvarafenib is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C...
|
T6525 |
GW 5074
|
220904-83-6
|
98%
|
|
GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, ...
|
T5172 |
AZ304
|
942507-42-8
|
98%
|
|
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
|
T63333 |
Uplarafenib
|
1425485-87-5
|
98%
|
|
Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation...
|
T1851 |
ZM 336372
|
208260-29-1
|
98%
|
|
ZM 336372 is a potent and selective c-Raf inhibitor.
|
T22272 |
Lifirafenib
|
1446090-79-4
|
98%
|
|
Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E...
|
T76089 |
Pepinh-TRIF TFA
|
|
98%
|
|
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction )....
|
T11898 |
LXH254
|
1800398-38-2
|
98%
|
|
LXH254 is a potent C-Raf and B-Raf inhibitor.
|
T4167 |
Raf inhibitor 1 dihydrochloride
|
1191385-19-9
|
98%
|
|
Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.
|
T6302 |
Lonafarnib
|
193275-84-2
|
98%
|
|
Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
|
T24437 |
MCP110
|
521310-51-0
|
98%
|
|
MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.
|
T6948 |
Pluripotin
|
839707-37-8
|
98%
|
|
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGA...
|
T1953 |
L-779450
|
303727-31-3
|
98%
|
|
L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
|
T2295 |
SB-590885
|
405554-55-4
|
98%
|
|
SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay). The selectivity of SB590885 for B-Raf is 11-fold greater over c-Raf, no acts to oth...
|
T0093 |
Sorafenib tosylate
|
475207-59-1
|
98%
|
|
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
|
T6949 |
PLX7904
|
1393465-84-3
|
98%
|
|
PLX7904 (PB04), also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRA...
|
T1903 |
Dabrafenib
|
1195765-45-7
|
98%
|
|
Dabrafenib (GSK2118436A) is a selective inhibitor of mutated forms of BRAF kinase (IC50s: 0.7/5 nM for B-Raf (V600E)/C-Raf).
|