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Ras

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T62228 KRAS G12D inhibitor 14 2765254-39-3 99.39%
KRAS G12D inhibitor 14
KRAS G12D inhibitor 14 is a potent inhibitor of KRAS G12D that binds KRAS G12D protein (Kd: 33 nM). KRAS G12D inhibitor 14 inhibits the active form of KRAS G12D ...
T72062 BI-2865 2937327-93-8 99.39%
BI-2865
BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respect...
T79213 AZD4747 2489226-14-2 99.36%
AZD4747
AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study...
T6342 NSC 23766 trihydrochloride 1177865-17-6 99.35%
NSC 23766 trihydrochloride
NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related ...
T6163 Salirasib 162520-00-5 99.33%
Salirasib
Salirasib (Farnesyl Thiosalicylic Acid)(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation w...
T8684 Sotorasib 2296729-00-3 99.25%
Sotorasib
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C...
T1892 Kobe2602 454453-49-7 99.24%
Kobe2602
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
T5S1261 Methylophiopogonanone B 74805-91-7 99.24%
Methylophiopogonanone B
1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.
T9303 MRTX1133 2621928-55-8 99.10%
MRTX1133
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors...
T8369 Adagrasib 2326521-71-3 99.10%
Adagrasib
Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C...
T16143 MRTX-1257 2206736-04-9 99.07%
MRTX-1257
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1...
T6462 Deltarasin 1440898-61-2 99.06%
Deltarasin
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
T11738 K-Ras G12C-IN-4 2376328-55-9 99.00%
K-Ras G12C-IN-4
K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..
T36082 Cysmethynil 851636-83-4 99%
Cysmethynil
Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmet...
T40186 Garsorasib 2559761-14-5 98.99%
Garsorasib
Garsorasib is an effective KRAS G12C inhibitor (IC50 = 10 nM) and can be used in studies about cancer treatment.
T10533 BI-2852 2375482-51-0 98.98%
BI-2852
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an an...
T16745 Rhosin hydrochloride 1281870-42-5 98.92%
Rhosin hydrochloride
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
T10375 ARS-1323 1698024-73-5 98.88%
ARS-1323
ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.
T40292 Opnurasib 2653994-08-0 98.88%
Opnurasib
Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell...
T4306 CCG-203971 1443437-74-8 98.82%
CCG-203971
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
KRAS G12D inhibitor 14
T62228
KRAS G12D inhibitor 14 is a potent inhibitor of KRAS G12D that binds KRAS G12D protein (Kd: 33 nM). KRAS G12D inhibitor 14 inhibits the active form of KRAS G12D ...
BI-2865
T72062
BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respect...
AZD4747
T79213
AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study...
NSC 23766 trihydrochloride
T6342
NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related ...
Salirasib
T6163
Salirasib (Farnesyl Thiosalicylic Acid)(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation w...
Sotorasib
T8684
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C...
Kobe2602
T1892
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
Methylophiopogonanone B
T5S1261
1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.
MRTX1133
T9303
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors...
Adagrasib
T8369
Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C...
MRTX-1257
T16143
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1...
Deltarasin
T6462
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
K-Ras G12C-IN-4
T11738
K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..
Cysmethynil
T36082
Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmet...
Garsorasib
T40186
Garsorasib is an effective KRAS G12C inhibitor (IC50 = 10 nM) and can be used in studies about cancer treatment.
BI-2852
T10533
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an an...
Rhosin hydrochloride
T16745
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
ARS-1323
T10375
ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.
Opnurasib
T40292
Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell...
CCG-203971
T4306
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
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