T62228 |
KRAS G12D inhibitor 14
|
2765254-39-3
|
99.39%
|
|
KRAS G12D inhibitor 14 is a potent inhibitor of KRAS G12D that binds KRAS G12D protein (Kd: 33 nM). KRAS G12D inhibitor 14 inhibits the active form of KRAS G12D ...
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T72062 |
BI-2865
|
2937327-93-8
|
99.39%
|
|
BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respect...
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T79213 |
AZD4747
|
2489226-14-2
|
99.36%
|
|
AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study...
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T6342 |
NSC 23766 trihydrochloride
|
1177865-17-6
|
99.35%
|
|
NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related ...
|
T6163 |
Salirasib
|
162520-00-5
|
99.33%
|
|
Salirasib (Farnesyl Thiosalicylic Acid)(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation w...
|
T8684 |
Sotorasib
|
2296729-00-3
|
99.25%
|
|
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C...
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T1892 |
Kobe2602
|
454453-49-7
|
99.24%
|
|
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
|
T5S1261 |
Methylophiopogonanone B
|
74805-91-7
|
99.24%
|
|
1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.
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T9303 |
MRTX1133
|
2621928-55-8
|
99.10%
|
|
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors...
|
T8369 |
Adagrasib
|
2326521-71-3
|
99.10%
|
|
Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C...
|
T16143 |
MRTX-1257
|
2206736-04-9
|
99.07%
|
|
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX1...
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T6462 |
Deltarasin
|
1440898-61-2
|
99.06%
|
|
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
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T11738 |
K-Ras G12C-IN-4
|
2376328-55-9
|
99.00%
|
|
K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..
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T36082 |
Cysmethynil
|
851636-83-4
|
99%
|
|
Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.Cysmet...
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T40186 |
Garsorasib
|
2559761-14-5
|
98.99%
|
|
Garsorasib is an effective KRAS G12C inhibitor (IC50 = 10 nM) and can be used in studies about cancer treatment.
|
T10533 |
BI-2852
|
2375482-51-0
|
98.98%
|
|
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an an...
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T16745 |
Rhosin hydrochloride
|
1281870-42-5
|
98.92%
|
|
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
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T10375 |
ARS-1323
|
1698024-73-5
|
98.88%
|
|
ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.
|
T40292 |
Opnurasib
|
2653994-08-0
|
98.88%
|
|
Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small cell...
|
T4306 |
CCG-203971
|
1443437-74-8
|
98.82%
|
|
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
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