T1002 |
Etodolac |
Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, ...
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T1051 |
Tretinoin |
Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell p...
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T1093 |
Adapalene |
Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions. |
T1288 |
TTNPB |
TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively. |
T1330 |
Acitretin |
Acitretin is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. |
T1611 |
Isotretinoin |
Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and ...
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T1872 |
Fenretinide |
Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities. |
T3955 |
AR7 |
AR7 is a retinoic acid receptor α (RARα) antagonist. |
T6410 |
Bexarotene |
Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). |
T6694 |
Tamibarotene |
Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. |
T6696 |
Tazarotene |
Tazarotene is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazar...
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T6831 |
Etretinate |
Etretinate is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an ind...
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T4371 |
CD437 |
CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist. |
T4538 |
palovarotene |
Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ). |
T5341 |
WYC209 |
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR). |
T5854 |
AM580 |
AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM ) |
T5843 |
R-flurbiprofen |
R-flurbiprofen is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Al...
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TQ0064 |
Peretinoin |
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR. |
TQ0097 |
AGN 193109 |
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ). |
T3000 |
Magnolol |
Magnolol is a dual agonist of RXRα( EC50=10.4 µM) and PPARγ(EC50=17.7 µM). It blocks TNF-α-induced NF-KB activation. |
T14143 |
AGN 194310 |
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2]. |
T14689 |
BMS493 |
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 increases nuclear corepre...
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T14911 |
CD2665 |
CD2665 is an antagonist of RAR-beta/gamma (Ki: 110 nM and 306 nM for RARγ and RARβ). |
T14912 |
CD3254 |
CD3254 a selective agonist of retinoid-X-receptor (RXR). |
T14946 |
Ch55 |
Ch55 is a potent inducer of the differentiation of HL60 cells (EC50: 200 nM). Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 shows a low aff...
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T15825 |
LY 178002 |
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production ...
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T16425 |
PA452 |
PA452 is a retinoic X receptor (RXR) specific antagonist. PA452 suppresses the effect of Retinoic acid (RA) on Th1/Th2 development. |