Retinoid Receptor

Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis. Subtypes include: Retinoic acid receptors (RARs), Retinoid X receptors (RXRs), RAR-related orphan receptors (RORs).

Cat. No.	Product name	CAS No.	Purity
T67921	Retinoic acid-d5	78996-15-3	98%
T67921	Retinoic acid-d5 (Vitamin A acid-d5) is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RA...
T14143	AGN 194310	229961-45-9	98%
T14143	AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
T15825	LY 178002	107889-32-7	98%
T15825	LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
T21686	CD 1530	107430-66-0	98%
T21686	CD 1530 is a selective and potent RARγ agonist (Kd:150 nM) with potential anticancer activity, shows insecticidal activity against Cryptobacterium hidradii nemat...
T1330	Acitretin	55079-83-9	99.95%
T1330	Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
T17209	UVI 3003	847239-17-2	99.94%
T17209	UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respective...
T78575	KCL-286	1952276-71-9	99.93%
T78575	KCL-286 is an orally available and potent retinoic acid receptor beta agonist for the amelioration of spinal cord injury (SCI).
T0499	Oxybenzone	131-57-7	99.92%
T0499	Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.
T1093	Adapalene	106685-40-9	99.88%
T1093	Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
TQ0064	Peretinoin	81485-25-8	99.86%
TQ0064	Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
T14090	AC-55649	59662-49-6	99.84%
T14090	AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
T11844	LG-100064	153559-46-7	99.79%
T11844	LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
T21714	BMS453	166977-43-1	99.78%
T21714	BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominan...
T7586	Trifarotene	895542-09-3	99.78%
T7586	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC...
T1872	Fenretinide	65646-68-6	99.72%
T1872	Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
T14911	CD2665	170355-78-9	99.67%
T14911	CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
T6696	Tazarotene	118292-40-3	99.67%
T6696	Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis...
T4371	CD437	125316-60-1	99.63%
T4371	CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
T1611	Isotretinoin	4759-48-2	99.61%
T1611	Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cel...
T22767	ER 50891	187400-85-7	99.49%
T22767	ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast d...