Home Tools
Log in
Cart

Retinoid Receptor

Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis. Subtypes include: Retinoic acid receptors (RARs), Retinoid X receptors (RXRs), RAR-related orphan receptors (RORs).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1611 Isotretinoin 4759-48-2 99.61%
Isotretinoin
Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cel...
T1051 Retinoic acid 302-79-4 99.52%
Retinoic acid
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid in...
T22767 ER 50891 187400-85-7 99.49%
ER 50891
ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast d...
T22843 HX 531 188844-34-0 99.43%
HX 531
RXR antagonist
TN6735 Bigelovin 3668-14-2 99.4%
Bigelovin
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pat...
T11847L Liarozole 115575-11-6 99.38%
Liarozole
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of ar...
T68104 Mofarotene 125533-88-2 99.36%
Mofarotene
Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tu...
TP1313L Cecropin B acetate 99.27%
Cecropin B acetate
Cecropin B acetate induces NF-κB activation and suppresses CYP3A29 by disrupting the association of the PXR/retinoid X receptor alpha (RXR-α) complex with DNA se...
T11303 Fluorobexarotene 1190848-23-7 99.23%
Fluorobexarotene
Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene  is a potent retinoid-X-receptor (RXR) agonist,...
T61588 AGN 192870 166977-57-7 99.22%
AGN 192870
AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.
T77499 MSU-42011 2456434-36-7 99.04%
MSU-42011
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
T14946 Ch55 110368-33-7 99.01%
Ch55
Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β recept...
T26854 BMS641 369364-50-1 98.98%
BMS641
BMS641 (BMS-209641) is a selective and potent RARβ agonist.BMS641 has a high affinity for RARβ and synergistically activates RARβ and RARgamma to induce cellular...
T5341 WYC-209 2131803-90-0 98.91%
WYC-209
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
T1288 TTNPB 71441-28-6 98.84%
TTNPB
TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respective...
TQ0097 AGN 193109 171746-21-7 98.81%
AGN 193109
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).
T14912 CD3254 196961-43-0 98.71%
CD3254
CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation.
T23005 MM 11253 345952-44-5 98.62%
MM 11253
MM 11253 is a RARγ antagonist with IC50 of 44nM.
T15811 LY2955303 1433497-19-8 98.56%
LY2955303
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
T14089 AC-261066 870773-76-5 98.44%
AC-261066
AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.
Isotretinoin
T1611
Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cel...
Retinoic acid
T1051
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid in...
ER 50891
T22767
ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast d...
HX 531
T22843
RXR antagonist
Bigelovin
TN6735
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pat...
Liarozole
T11847L
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of ar...
Mofarotene
T68104
Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tu...
Cecropin B acetate
TP1313L
Cecropin B acetate induces NF-κB activation and suppresses CYP3A29 by disrupting the association of the PXR/retinoid X receptor alpha (RXR-α) complex with DNA se...
Fluorobexarotene
T11303
Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene  is a potent retinoid-X-receptor (RXR) agonist,...
AGN 192870
T61588
AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.
MSU-42011
T77499
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
Ch55
T14946
Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β recept...
BMS641
T26854
BMS641 (BMS-209641) is a selective and potent RARβ agonist.BMS641 has a high affinity for RARβ and synergistically activates RARβ and RARgamma to induce cellular...
WYC-209
T5341
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
TTNPB
T1288
TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respective...
AGN 193109
TQ0097
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).
CD3254
T14912
CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation.
MM 11253
T23005
MM 11253 is a RARγ antagonist with IC50 of 44nM.
LY2955303
T15811
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
AC-261066
T14089
AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.
1 2 3
TargetMol