T7370 |
Talarozole
|
201410-53-9
|
98%
|
|
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5....
|
T5854 |
AM580
|
102121-60-8
|
98%
|
|
AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
|
T22192 |
BMS 195614
|
253310-42-8
|
97.7%
|
|
BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.
|
T6694 |
Tamibarotene
|
94497-51-5
|
97.22%
|
|
Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic a...
|
T1051 |
Retinoic acid
|
302-79-4
|
97.21%
|
|
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid in...
|
T16425 |
PA452
|
457657-34-0
|
96.76%
|
|
PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.
|
T3000 |
Magnolol
|
528-43-8
|
100%
|
|
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
|
T5843 |
Tarenflurbil
|
51543-40-9
|
100%
|
|
Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as...
|
T10261 |
AGN 196996
|
958295-17-5
|
|
|
AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM).AGN 196996 has very low affinity for RARβ and RARγ, with a Ki of 1087 nM and 8523 nM, respectiv...
|
T14689 |
BMS493
|
215030-90-3
|
98%
|
|
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-...
|
T28589 |
Ro 41-5253
|
144092-31-9
|
98%
|
|
Ro 41-5253 is an orally active RARα antagonist, ligand and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity...
|
T61588 |
AGN 192870
|
166977-57-7
|
98%
|
|
AGN 192870 is a potent retinoic acid receptor (RAR) antagonist.AGN 192870 can be used to study cell growth arrest, differentiation and apoptosis.
|
T26854 |
BMS641
|
369364-50-1
|
98%
|
|
BMS641 (BMS-209641) is a selective and potent RARβ agonist.BMS641 has a high affinity for RARβ and synergistically activates RARβ and RARgamma to induce cellular...
|
T1002 |
Etodolac
|
41340-25-4
|
98%
|
|
Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pai...
|
T3955 |
AR7
|
80306-38-3
|
98%
|
|
AR7 is a retinoic acid receptor α (RARα) antagonist.
|