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GPCR/G Protein S1P Receptor

S1P Receptor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. .
Cat No. product name
T2026 CYM5442 CYM5442 is an S1P agonist, targeting to Sphingosine.
T2539 Fingolimod hydrochlorideHOT Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T3258 Ponesimod Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating ...
T3961 CYM 5541 CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T4031 S1p-receptor-agonist-1 An S1P receptor agonist.
T6085 PF-543 PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T6403 Siponimod BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM,respectively. The specifi...
T6673 SKI II SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKC...
T6750 ABC294640 ABC294640 is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
T6923 Ozanimod Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, ...
T4658 MHP MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
T7360 GSK2018682 GSK2018682 is an agonist of sphingosine-1-phosphate receptor  (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
TQ0138 K145 hydrochloride K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.
TQ0227 Etrasimod Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
TQ0198 Phorbol 12-myristate 13-acetate Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
T7939 Fingolimod Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T12436 PF-543 Citrate PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T12437 PF429242 dihydrochloride PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
T10385 ASP-4058 ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety pr...
T12927 SK1-IN-1 SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T11747 KD-3010 KD-3010 is a orally, potent active, and selective PPARδ agonist.
T17183 TY-52156 TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T17237 VPC 23019 VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (p...
CYM5442
T2026CAS 1094042-01-9
CYM5442 is an S1P agonist, targeting to Sphingosine.
Fingolimod hydrochloride HOT
T2539CAS 162359-56-0
Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
Ponesimod
T3258CAS 854107-55-4
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating ...
CYM 5541
T3961CAS 945128-26-7
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
S1p-receptor-agonist-1
T4031CAS 1514888-56-2
An S1P receptor agonist.
PF-543
T6085CAS 1415562-82-1
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
Siponimod
T6403CAS 1230487-00-9
BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM,respectively. The specifi...
SKI II
T6673CAS 312636-16-1
SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKC...
ABC294640
T6750CAS 915385-81-8
ABC294640 is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
Ozanimod
T6923CAS 1306760-87-1
Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, ...
MHP
T4658CAS 1104874-94-3
MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
GSK2018682
T7360CAS 1034688-30-6
GSK2018682 is an agonist of sphingosine-1-phosphate receptor  (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
K145 hydrochloride
TQ0138CAS 1449240-68-9
K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.
Etrasimod
TQ0227CAS 1206123-37-6
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
Phorbol 12-myristate 13-acetate
TQ0198CAS 16561-29-8
Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
Fingolimod
T7939CAS 162359-55-9
Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
PF-543 Citrate
T12436CAS 1415562-83-2
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
PF429242 dihydrochloride
T12437CAS 2248666-66-0
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
ASP-4058
T10385CAS 952565-91-2
ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety pr...
SK1-IN-1
T12927CAS 1218816-71-7
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
KD-3010
T11747CAS 934760-92-6
KD-3010 is a orally, potent active, and selective PPARδ agonist.
TY-52156
T17183CAS 934369-14-9
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
VPC 23019
T17237CAS 449173-19-7
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (p...
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