S1P Receptor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. .

Cat No.	product name
T2026	CYM5442	CYM5442 is an S1P agonist, targeting to Sphingosine.
T2171	SEW2871	Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
T2539	Fingolimod hydrochlorideHOT	Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T3258	Ponesimod	Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating ...
T3961	CYM 5541	CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T4031	S1p-receptor-agonist-1	An S1P receptor agonist.
T6085	PF543	PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T6403	Siponimod	BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specif...
T6673	SKI II	SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKC...
T6750	ABC294640	ABC294640 is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
T6923	Ozanimod	Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, ...
T4658	MHP	MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
T7360	GSK2018682	GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
TQ0138	K145 hydrochloride	K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.
TQ0227	Etrasimod	Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
TQ0198	Phorbol 12-myristate 13-acetate	Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
T7939	Fingolimod	Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T12436	PF-543 Citrate	PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T12437	PF429242 dihydrochloride	PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
T10385	ASP-4058	ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety pr...
T12927	SK1-IN-1	SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T11747	KD-3010	KD-3010 is a orally, potent active, and selective PPARδ agonist.
T17183	TY-52156	TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T17237	VPC 23019	VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (p...
T15032	CYM50308	CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes...
T10305	Amiselimod hydrochloride	Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T8840	PF-543	PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
T8461	SKI V	SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), indu...
T22703	CYM 5520	noncompetitive allosteric agonist of S1P2