T17237 |
VPC 23019
|
449173-19-7
|
98%
|
|
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
|
T12927 |
SK1-IN-1
|
1218816-71-7
|
98%
|
|
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
|
T12436 |
PF-543 Citrate
|
1415562-83-2
|
98%
|
|
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
|
T6673 |
SKI II
|
312636-16-1
|
99.97%
|
|
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases inclu...
|
T4031 |
S1p receptor agonist 1
|
1514888-56-2
|
99.94%
|
|
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.
|
T8840 |
PF-543 hydrochloride
|
1706522-79-3
|
99.92%
|
|
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isofo...
|
TQ0064 |
Peretinoin
|
81485-25-8
|
99.86%
|
|
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
|
T7939 |
Fingolimod
|
162359-55-9
|
99.76%
|
|
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
|
T6923 |
Ozanimod
|
1306760-87-1
|
99.74%
|
|
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative...
|
T17183 |
TY-52156
|
934369-14-9
|
99.73%
|
|
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
|
T10305 |
Amiselimod hydrochloride
|
942398-84-7
|
99.68%
|
|
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
|
T8461 |
SKI V
|
24418-86-8
|
99.62%
|
|
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces...
|
T2171 |
SEW2871
|
256414-75-2
|
99.62%
|
|
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies r...
|
T10385 |
ASP-4058
|
952565-91-2
|
99.51%
|
|
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
|
T38826 |
Vibozilimod
|
1403232-33-6
|
99.47%
|
|
Vibozilimod (SCD-044) is S1P receptor-1 (S1PR1) agonist .
|
T4658 |
MHP
|
1104874-94-3
|
99.45%
|
|
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
|
T15032 |
CYM50308
|
1345858-76-5
|
99.43%
|
|
CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
|
T3258 |
Ponesimod
|
854107-55-4
|
99.42%
|
|
Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
|
T63047 |
SLP9101555
|
T63047
|
99.40%
|
|
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
|
T60204 |
W140 HBr
|
1246817-25-3
|
99.34%
|
|
[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM.
|