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S1P Receptor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. .
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2539 Fingolimod hydrochloride 162359-56-0 99.29%
Fingolimod hydrochloride
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T9014 SKI-178 1259484-97-3 99.2%
SKI-178
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic ...
TQ0227 Etrasimod 1206123-37-6 99.17%
Etrasimod
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
TQ0138 K145 hydrochloride 1449240-68-9 99.09%
K145 hydrochloride
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can ...
T15629 JTE-013 383150-41-2 98.87%
JTE-013
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T6750 Opaganib 915385-81-8 98.86%
Opaganib
Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
T22703 CYM-5520 1449747-00-5 98.72%
CYM-5520
CYM-5520 is a noncompetitive allosteric agonist of S1P2
T12437 PF429242 dihydrochloride 2248666-66-0 98.67%
PF429242 dihydrochloride
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
TQ0198 Phorbol 12-myristate 13-acetate 16561-29-8 98.55%
Phorbol 12-myristate 13-acetate
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13...
T27710 K6PC-5 756875-51-1 98.55%
K6PC-5
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. W...
T22101 ML-031 852230-33-2 98.29%
ML-031
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.
T22697 CS 2100 913827-99-3 98.13%
CS 2100
CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist.
T9199 GLPG2938 2130996-00-6 98.1%
GLPG2938
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
T16128 MP-A08 219832-49-2 98.04%
MP-A08
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectiv...
T6403 Siponimod 1230487-00-9 97.79%
Siponimod
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
T7360 GSK2018682 1034688-30-6 97.78%
GSK2018682
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T26866 BMS-960 1265321-86-5 97.74%
BMS-960
BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.
T10761 Ceranib-2 1402830-75-4 97.49%
Ceranib-2
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decr...
T3961 CYM-5541 945128-26-7 97.34%
CYM-5541
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
T2026 CYM5442 1094042-01-9 96.65%
CYM5442
CYM5442 is an S1P agonist, targeting to Sphingosine.
Fingolimod hydrochloride
T2539
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
SKI-178
T9014
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic ...
Etrasimod
TQ0227
Etrasimod (APD334) is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 nM in CHO cells).
K145 hydrochloride
TQ0138
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can ...
JTE-013
T15629
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
Opaganib
T6750
Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
CYM-5520
T22703
CYM-5520 is a noncompetitive allosteric agonist of S1P2
PF429242 dihydrochloride
T12437
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
Phorbol 12-myristate 13-acetate
TQ0198
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13...
K6PC-5
T27710
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. W...
ML-031
T22101
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.
CS 2100
T22697
CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist.
GLPG2938
T9199
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
MP-A08
T16128
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectiv...
Siponimod
T6403
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
GSK2018682
T7360
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
BMS-960
T26866
BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.
Ceranib-2
T10761
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decr...
CYM-5541
T3961
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
CYM5442
T2026
CYM5442 is an S1P agonist, targeting to Sphingosine.
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TargetMol