Search Result

Search Results for " s6-kinase "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TP2200	S6 Kinase Substrate Peptide 32		Others
	S6 Kinase Substrate Peptide 32 is a peptide that measures the activity of kinases that phosphorylate ribosomal protein S6. It can also be used as a substrate.		Others
T22422	S6K-18		S6 Kinase
	S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.		S6 Kinase
T5428	BIX 02565		LRRK2 , S6 Kinase
	BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).		LRRK2 , S6 Kinase
T6304	AT7867		Akt , PKA , S6 Kinase
	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.		Akt , PKA , S6 Kinase
T6877	LJH685		Apoptosis , S6 Kinase
	LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).		Apoptosis , S6 Kinase
T2482	AT13148		ROCK , SGK , Akt , PKA , S6 Kinase
	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.		ROCK , SGK , Akt , PKA , S6 Kinase
T2002	PF-4708671	PF4708671	S6 Kinase , Autophagy
	PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC50=160 nM).		S6 Kinase , Autophagy
T4488	GSK-25	GSK25	ROCK , S6 Kinase , mTOR
	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).		ROCK , S6 Kinase , mTOR
T4301	AD80		Raf , c-RET , Src , S6 Kinase
	AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.		Raf , c-RET , Src , S6 Kinase
T6171	BI-D1870		S6 Kinase , Autophagy
	BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for RSK1/2/3/4).		S6 Kinase , Autophagy
T6878	LJI308		S6 Kinase
	LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.		S6 Kinase
T14779	BRD7389		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
	BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
T6948	Pluripotin	SC1	ERK , Raf , S6 Kinase
	Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.		ERK , Raf , S6 Kinase
T6159	LY-2584702 free base		S6 Kinase , mTOR
	LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).		S6 Kinase , mTOR
T7790	Bisindolylmaleimide V		PKC , S6 Kinase
	Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.		PKC , S6 Kinase
T1746	LY-2584702 tosylate salt	LY2584702 tosylate	S6 Kinase
	LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.		S6 Kinase
T19913	CKI-7	CKI 7 2HCl,CKI-7 dihydrochloride,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl	ROCK , SGK , Casein Kinase , CDK , S6 Kinase
	CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.		ROCK , SGK , Casein Kinase , CDK , S6 Kinase
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T77628	Bisindolylmaleimide III		PKC
	Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6 protein kinase 1 upon activation of these kinases.		PKC
T16567	PQR530	PQR-530	PI3K , mTOR
	PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitu...		PI3K , mTOR
T36675	ERK Inhibitor
	ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-speci...
T6334	Ridaforolimus	AP23573,Deforolimus,MK-8669	mTOR , Autophagy
	Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamyc...		mTOR , Autophagy
T11310	FMK-MEA		Others
	FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.		Others
T10829	CKI-7 free base	CKI-7	Casein Kinase
	CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.		Casein Kinase
T81231	S6 peptide
	S6 peptide, a lamin kinase of potential importance, plays a role in the induction of cardiac hypertrophy following mechanical loading and can be activated by various growth factors [1].
T68477	XL-418
	XL-418 is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S...

Compounds

S6 Kinase Substrate Peptide 32

Target: LRRK2, S6 Kinase

AT7867

T6304

Synonym:

Target: Akt, PKA, S6 Kinase

LJH685

T6877

Synonym:

Target: Apoptosis, S6 Kinase

AT13148

T2482

Synonym:

Target: ROCK, SGK, Akt, PKA, S6 Kinase

PF-4708671

T2002

Synonym: PF4708671

Target: S6 Kinase, Autophagy

GSK-25

T4488

Synonym: GSK25

Target: ROCK, S6 Kinase, mTOR

AD80

T4301

Synonym:

Target: Raf, c-RET, Src, S6 Kinase

BI-D1870

T6171

Synonym:

Target: S6 Kinase, Autophagy

Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK

Pluripotin

T6948

Synonym: SC1

Target: ERK, Raf, S6 Kinase

LY-2584702 free base

T6159

Synonym:

Target: S6 Kinase, mTOR

Bisindolylmaleimide V

T7790

Synonym:

Target: PKC, S6 Kinase

LY-2584702 tosylate salt

T1746

Synonym: LY2584702 tosylate

Target: S6 Kinase

CKI-7

T19913

Synonym: CKI 7 2HCl,CKI-7 dihydrochloride,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl

Target: ROCK, SGK, Casein Kinase, CDK, S6 Kinase

DD1

T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Proteasome

Bisindolylmaleimide III

Synonym: AP23573,Deforolimus,MK-8669

Target: mTOR, Autophagy

Target: Casein Kinase

Cat No.	Product Name	Synonyms	Targets
T6S1302	Carnosol		Nrf2 , Endogenous Metabolite , S6 Kinase
	Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value ...		Nrf2 , Endogenous Metabolite , S6 Kinase
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T2871	Quercitrin	Sophoretin,3-rhamnosyl quercetin,Quercetin 3-rhamnoside,Xanthaurine,Meletin	Reactive Oxygen Species , S6 Kinase , Autophagy
	Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such as garden tomato (var. ), German cam...		Reactive Oxygen Species , S6 Kinase , Autophagy
T0335	Sodium salicylate	Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt	Apoptosis , NF-κB , COX , S6 Kinase , Autophagy
	Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.		Apoptosis , NF-κB , COX , S6 Kinase , Autophagy
T16896	SL 0101-1	SL0101	S6 Kinase
	SL 0101-1 (SL0101) is a selective, efficient, reversible and ATP-competitive inhibitor of p90 ribosomal S6 kinase (RSK) that can permeate cell membranes, with an IC50 value of 89 nM for RSK.SL 0101-1 (SL0101) is also a p...		S6 Kinase

Natural Products

Carnosol

T6S1302

Synonym:

Target: Nrf2, Endogenous Metabolite, S6 Kinase

Eudesmin

T3836

Synonym:

Target: MAPK, S6 Kinase

Quercitrin

T2871

Synonym: Sophoretin,3-rhamnosyl quercetin,Quercetin 3-rhamnoside,Xanthaurine,Meletin

Target: Reactive Oxygen Species, S6 Kinase, Autophagy

Sodium salicylate

T0335

Synonym: Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt

Target: Apoptosis, NF-κB, COX, S6 Kinase, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04357	RSK4 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kina...
TMPY-04392	RSK3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a ...
TMPY-04540	S6K1/RPS6KB1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase...
TMPH-00065	MRJP1 Protein, Apis mellifera, Recombinant (GST)	Apis mellifera	E. coli
	Induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vite...
TMPH-00064	MRJP1 Protein, Apis mellifera, Recombinant (His)	Apis mellifera	Yeast
	Induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vite...