S6 Kinase

In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2.

Cat. No.	Product name	CAS No.	Purity
T11900	LY-2584702 hydrochloride	1082948-81-9	98%
T11900	Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.
T7790	Bisindolylmaleimide V	113963-68-1	98%
T7790	Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
T24398	Lenaldekar	418800-15-4	98%
T24398	Lenaldekar is a T-cell expansion and autoimmune encephalomyelitis inhibitor.
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T11961	MBM-55S	2083624-07-9	98%
T11961	MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
T19913	CKI-7	1177141-67-1	100.00%
T19913	CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
T6458	CYC-116	693228-63-6	96.6%
T6458	CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
T1961	Vistusertib	1009298-59-2	97.94%
T1961	AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
T6877	LJH685	1627710-50-2	98%
T6877	LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).
T2482	AT13148	1056901-62-2	98.04%
T2482	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T6250	H-89 dihydrochloride	130964-39-5	98.38%
T6250	H 89 is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 µM, Ki: 48 nM).
T6159	LY-2584702 free base	1082949-67-4	98.72%
T6159	LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
T1746	LY-2584702 tosylate salt	1082949-68-5	98.8%
T1746	LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.
T6948	Pluripotin	839707-37-8	98.82%
T6948	Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
T6878	LJI308	1627709-94-7	98.86%
T6878	LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.
T3079	GSK1838705A	1116235-97-2	98.89%
T3079	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
T2871	Quercitrin	522-12-3	98.9%
T2871	Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
TN1712	Gossypin	652-78-8	98.97%
TN1712	Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the...
T6S1302	Carnosol	5957-80-2	99%
T6S1302	Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer c...
T4488	GSK-25	874119-56-9	99.14%
T4488	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...