STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.

Cat. No.	Product name	CAS No.	Purity
TN1775	Isocryptotanshinone	22550-15-8	98%
TN1775	Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative r...
TMA1743	Ergosterol peroxide	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
T74950	Antitumor agent-73	2812356-72-0	98%
T74950	Antitumor Agent-73, a derivative of Diosgenin, both impedes STAT3 signaling and exogenously stimulates Pdia3/ERp57. This compound demonstrates significant antine...
T11449	Golotimod hydrochloride (229305-39-9 free base)	T11449	98%
T11449	Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis...
TN4489	Manassantin A	88497-87-4	98%
TN4489	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
T15234	ENMD-1198	864668-87-1	98%
T15234	ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
TN4356	Jolkinolide A	37905-07-0	98%
TN4356	Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
TN2775	2-Methoxystypandrone	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TN4604	Myricanone	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN4490	Manassantin B	88497-88-5	98%
TN4490	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV ...
TN1985	Neoprzewaquinone A	630057-39-5	98%
TN1985	Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 ...
TP2222L	APTSTAT3-9R acetate		98%
TP2222L	APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity. APTSTAT3-9R acetate and inhibits STAT3 activation and dow...
T4571	Balsalazide	80573-04-2	98%
T4571	Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
T71550	STAT3-IN-8	1041438-68-9	98%
T71550	"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."
T24838	Stafib-1	1688703-26-5	98%
T24838	Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.
T14330	Ascochlorin	26166-39-2	98%
T14330	Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, primarily exerts its anti-tumor properties by inhibiting the STAT3 signaling pathway. It induces apoptosis ...
T121011	TLC1566-0618	708218-62-6	98%
T121011	TLC1566-0618 shows antitumor activity and targets stat.
TN3541	Broussonin E	90902-21-9	98%
TN3541	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
T21267	HODHBt	28230-32-2	99.99%
T21267	HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
TN1059	Ganoderic acid B	81907-61-1	99.95%
TN1059	Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards th...