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STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T21267 HODHBt 28230-32-2 99.99%
HODHBt
HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
TN1674 Garcinone D 107390-08-9 99.94%
Garcinone D
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
TN2269 Tetramethylcurcumin 52328-97-9 99.94%
Tetramethylcurcumin
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also i...
T8597 ML116 744270-00-6 99.94%
ML116
ML116 is a potent and selective STAT3 inhibitor.
T0433 Artesunate 88495-63-0 99.91%
Artesunate
Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and m...
T2896 Alantolactone 546-43-0 99.91%
Alantolactone
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing th...
T3971 CASIN 425399-05-9 99.86%
CASIN
CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
T6S1966 Curculigoside 85643-19-2 99.85%
Curculigoside
1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulat...
T2168 2-(1,8-naphthyridin-2-yl)phenol 65182-56-1 99.84%
2-(1,8-naphthyridin-2-yl)phenol
2-NP is a STAT1 enhancer.
T0711L Niclosamide olamine 1420-04-8 99.83%
Niclosamide olamine
Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.
T8546 BD750 892686-59-8 99.76%
BD750
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in ...
T5S1607 Morusin 62596-29-6 99.72%
Morusin
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuat...
T8719 SC99 882290-02-0 99.68%
SC99
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation...
T6308 Stattic 19983-44-9 99.64%
Stattic
Stattic (STAT3 Inhibitor V) is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation (IC50: 5.1 ...
T2546 Pimozide 2062-78-4 99.63%
Pimozide
Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopamine...
T8213 Isolinderalactone 957-66-4 99.62%
Isolinderalactone
Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
T15582 InS3-54A18 328998-53-4 99.54%
inS3-54A18
inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
T21694 (R)-Lisofylline 100324-81-0 99.50%
(R)-Lisofylline
(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated ...
T3S1775 Tectochrysin 520-28-5 99.49%
Tectochrysin
1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrys...
T4S0145 Corylifol A 775351-88-7 99.48%
Corylifol A
1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respe...
HODHBt
T21267
HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
Garcinone D
TN1674
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
Tetramethylcurcumin
TN2269
Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also i...
ML116
T8597
ML116 is a potent and selective STAT3 inhibitor.
Artesunate
T0433
Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and m...
Alantolactone
T2896
Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing th...
CASIN
T3971
CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
Curculigoside
T6S1966
1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulat...
2-(1,8-naphthyridin-2-yl)phenol
T2168
2-NP is a STAT1 enhancer.
Niclosamide olamine
T0711L
Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.
BD750
T8546
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in ...
Morusin
T5S1607
1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuat...
SC99
T8719
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation...
Stattic
T6308
Stattic (STAT3 Inhibitor V) is a small molecule inhibitor of STAT3. It selectively inhibits STAT3 activation, dimerization, and nuclear translocation (IC50: 5.1 ...
Pimozide
T2546
Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopamine...
Isolinderalactone
T8213
Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
inS3-54A18
T15582
inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
(R)-Lisofylline
T21694
(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated ...
Tectochrysin
T3S1775
1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrys...
Corylifol A
T4S0145
1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respe...
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TargetMol