STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.

Cat. No.	Product name	CAS No.	Purity
T9043	AS1810722	909561-15-5	99.13%
T9043	AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhi...
T6669	SH-4-54	1456632-40-8	99.12%
T6669	SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.
T3913	Saikosaponin D	20874-52-6	99.09%
T3913	Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T3404	Cucurbitacin B	6199-67-3	99.08%
T3404	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation throug...
T2156	WP1066	857064-38-1	99.07%
T2156	WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has ...
T2505	S3I-201	501919-59-1	99.05%
T2505	S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
T6537	HO-3867	1172133-28-6	99%
T6537	HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
T9646	Stafib-2	2097938-74-2	98.97%
T9646	Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM, respect...
T5S0761	Nitidine chloride	13063-04-2	98.91%
T5S0761	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T62491	STAT3-IN-13	2248552-86-3	98.89%
T62491	STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3...
T22142	RO8191	691868-88-9	98.85%
T22142	RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
T4650	C188-9	432001-19-9	98.83%
T4650	C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.
T27613	InS3-54-A26	328998-77-2	98.83%
T27613	inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.
T8476	RSVA405	140405-36-3	98.71%
T8476	RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
T4476	AS1517499	919486-40-1	98.7%
T4476	AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
T6677	Sophocarpine	6483-15-4	98.67%
T6677	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T3708	BP-1-102	1334493-07-0	98.61%
T3708	BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interac...
T11807	L002	321695-57-2	98.59%
T11807	L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket a...
T3380	Homoharringtonine	26833-87-4	98.59%
T3380	Homoharringtonine (HHT) is a natural alkaloid that inhibits the translation of proteins and is cytotoxic. Homoharringtonine acts on the ribosomes of tumor cells ...
TN1237	3-O-Methylgallic acid	3934-84-7	98.53%
TN1237	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may...