STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.

Cat. No.	Product name	CAS No.	Purity
T3398	Icaritin	118525-40-9	98.50%
T3398	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase...
T61030	STAT3-IN-11	2503096-50-0	98.3%
T61030	STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.STAT3-IN-11 promot...
TQ0196	Cucurbitacin I	2222-07-3	98.2%
TQ0196	Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
T9339	Stafia-1	2582757-90-0	98.15%
T9339	Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
T62105	NT219	1198078-60-2	98.06%
T62105	NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of c...
T16940	STAT5-IN-2	2111834-61-6	98.02%
T16940	STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).
T4216	STAT5-IN-1	285986-31-4	98%
T4216	STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
T5668	Triacetylresveratrol	42206-94-0	98%
T5668	Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulate...
T2814	Cryptotanshinone	35825-57-1	98%
T2814	Cryptotanshinone (Cryptotanshinon), a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effec...
TN6739	Angoline	21080-31-9	97.9%
TN6739	Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosp...
T5S0167	Atractylenolide I	73069-13-3	97.55%
T5S0167	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
T4605	NT157	1384426-12-3	97.55%
T4605	NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal c...
T6995	Ochromycinone	111540-00-2	97.48%
T6995	Ochromycinone (STA 21) is a selective STAT3 inhibitor.
T19826	Rabeprazole	117976-89-3	97.06%
T19826	Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can b...
T13950	UC-514321	299420-83-0	97%
T13950	UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, wi...
T0711	Niclosamide	50-65-7	96.83%
T0711	Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
TN1405	Arnicolide D	34532-68-8	96.66%
TN1405	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
TP1856	Colivelin	867021-83-8	96.56%
TP1856	Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
T6838	FLLL32	1226895-15-3	96.39%
T6838	FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
T9949	NSC 370284	116409-29-1	96.16%
T9949	NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level o...