Amiloride hydrochloride is an effective sodium channel blocker of epithelial. |
Gabexate mesylate is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a...
Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex. |
Diminazene is a trypanocidal agent. |
SRPIN340, a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM). |
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression. |
Nafamostat mesylate, a synthetic serine protease inhibitor,has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic de...
Alvelestat is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity. |
Aprotinin a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin...
ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. |
UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulce...
AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase. |
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1. |
against HIV-1. |
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent. |
Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM. |
Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively). |
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM). |
Benzamidine HCl is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 µM, respectively). |
AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM). |
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine...
BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively. |
||BCX 1470 methanesulfonate
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respect...
Upamostat is an inhibitor of serine protease, and is a urokinase plasminogen activator (uPA) inhibitor. |
ZEN-3411 is an inhibitor of BET(IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively). ZEN-3411 can be used to form PROTACs ...
ZLN024 hydrochloride is an activator of AMPK allosteric. |
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity. |
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα producti...
ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM). |
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fo...