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Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.

Cat No.	product name
T0678	Amitriptyline hydrochloride	Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T1740	BD1047.2HBr	BD-1047 hydrobromide, a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.
T1865	S1RA	S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
T1885	Siramesine hydrochloride	Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anti...
T3198	PRE-084 hydrochloride	PRE-084 hydrochloride is a high affinity, selective σ1 agonist.
T3597	Cutamesine dihydrochloride	Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-...
T4111	Anavex 2-73	Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM).
T4229	S1RA hydrochloride	S1RA HCl (E-52862 HCl) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
T4166	UNC-0642	UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
T4596	4-IBP	4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
T5027	Dimemorfan phosphate	Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
T5969	Ditolylguanidine	Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
T7488	BD1063	BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
T7952	Noscapine	Noscapine is a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma.
T15393	Glycerol phenylbutyrate	Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T12911	Sigma-1 receptor antagonist 2	Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively...
T19341	Glycerol phenylbutyrate-D15	Glycerol phenylbutyrate -D15(GPB) is a new generation ammonia scavenger drug. Glycerol phenylbutyrate-D15 is a deuterium labeled Glycerol phenylbutyrate. Gly...
T19342	Glycerol phenylbutyrate-D5	Glycerol phenylbutyrate -D5(GPB) is a new generation ammonia scavenger drug.Glycerol phenylbutyrate-D5 is a deuterium labeled Glycerol phenylbutyrate. Glycero...
T16445	PD 144418	PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM f...