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GPCR/G Protein Sigma receptor

Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.
Cat No. product name
T0678 Amitriptyline hydrochloride Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T1740 BD1047.2HBr BD-1047 hydrobromide, a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.
T1865 S1RA S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
T1885 Siramesine hydrochloride Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anti...
T3198 PRE-084 hydrochloride PRE-084 hydrochloride is a high affinity, selective σ1 agonist.
T3597 Cutamesine dihydrochloride Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-...
T4111 Anavex 2-73 Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM).
T4229 S1RA hydrochloride S1RA HCl (E-52862 HCl) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
T4166 UNC-0642 UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
T4596 4-IBP 4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
T5027 Dimemorfan phosphate Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
T5969 Ditolylguanidine Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
T7488 BD1063 BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
T7952 Noscapine Noscapine is a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma.
T15393 Glycerol phenylbutyrate Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T12911 Sigma-1 receptor antagonist 2 Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively...
T19341 Glycerol phenylbutyrate-D15  Glycerol phenylbutyrate -D15(GPB) is a new generation ammonia scavenger drug. Glycerol phenylbutyrate-D15 is a deuterium labeled Glycerol phenylbutyrate. Gly...
T19342 Glycerol phenylbutyrate-D5  Glycerol phenylbutyrate -D5(GPB) is a new generation ammonia scavenger drug.Glycerol phenylbutyrate-D5 is a deuterium labeled Glycerol phenylbutyrate. Glycero...
T16445 PD 144418 PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM f...
Amitriptyline hydrochloride
T0678CAS 549-18-8
Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
BD1047.2HBr
T1740CAS 138356-21-5
BD-1047 hydrobromide, a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.
S1RA
T1865CAS 878141-96-9
S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
Siramesine hydrochloride
T1885CAS 224177-60-0
Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anti...
PRE-084 hydrochloride
T3198CAS 138847-85-5
PRE-084 hydrochloride is a high affinity, selective σ1 agonist.
Cutamesine dihydrochloride
T3597CAS 165377-44-6
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-...
Anavex 2-73
T4111CAS 195615-84-0
Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM).
S1RA hydrochloride
T4229CAS 1265917-14-3
S1RA HCl (E-52862 HCl) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
UNC-0642
T4166CAS 1481677-78-4
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
4-IBP
T4596CAS 155798-08-6
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
Dimemorfan phosphate
T5027CAS 36304-84-4
Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.
Ditolylguanidine
T5969CAS 97-39-2
Ditolylguanidine is an agonist of sigma receptor (σ1/σ2 receptor).
BD1063
T7488CAS 206996-13-6
BD1063 is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
Noscapine
T7952CAS 128-62-1
Noscapine is a Non-addictive Opioid and Microtubule-Inhibitor in Potential Treatment of Glioblastoma.
Glycerol phenylbutyrate
T15393CAS 611168-24-2
Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
Sigma-1 receptor antagonist 2
T12911CAS 1639220-15-7
Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively...
Glycerol phenylbutyrate-D15
T19341CAS
 Glycerol phenylbutyrate -D15(GPB) is a new generation ammonia scavenger drug. Glycerol phenylbutyrate-D15 is a deuterium labeled Glycerol phenylbutyrate. Gly...
Glycerol phenylbutyrate-D5
T19342CAS
 Glycerol phenylbutyrate -D5(GPB) is a new generation ammonia scavenger drug.Glycerol phenylbutyrate-D5 is a deuterium labeled Glycerol phenylbutyrate. Glycero...
PD 144418
T16445CAS 154130-99-1
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM f...