sigma-receptor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12910	Sigma-1 receptor antagonist 1		Sigma receptor
	Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studie...		Sigma receptor
T12911	Sigma-1 receptor antagonist 2		Sigma receptor
	Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).		Sigma receptor
T12912	Sigma-1 receptor antagonist 3		Sigma receptor , HER
	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.		Sigma receptor , HER
T16883	Sigma-2 receptor antagonist 1		Others
	Sigma-2 receptor antagonist 1 is an antagonist of the sigma-2 (σ-2) receptor.		Others
T4596	4-IBP		Sigma receptor
	4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .		Sigma receptor
T9244	σ1 Receptor antagonist-1		Sigma receptor
	σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.		Sigma receptor
T7488	BD1063 dhydrochloride	BD1063	Sigma receptor
	BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).		Sigma receptor
T78734	Sigma-1 receptor antagonist 5		Sigma receptor
	Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (Ki=4.5 nM (σ1R), 10 nM (σ2R)) and the histamine H3 receptor...		Sigma receptor
T5027	Dimemorfan phosphate	3,17-dimethylmorphinan	Sigma receptor
	Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.		Sigma receptor
T1180	Blonanserin	AD-5423	Dopamine Receptor , Sigma receptor , 5-HT Receptor , Adrenergic Receptor
	Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal ...
T15393	Glycerol phenylbutyrate	HPN-100	Sigma receptor
	Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).		Sigma receptor
T7780	Blarcamesine	AE-37,AVex-73	AChR
	Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.		AChR
T15034	Roluperidone	CYR-101,MIN-101,MT-210	Sigma receptor , 5-HT Receptor
	Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).		Sigma receptor , 5-HT Receptor
T1740	BD-1047 dihydrobromide	BD1047.2HBr	Sigma receptor
	BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.		Sigma receptor
T8834	EST64454 hydrochloride	EST64454	Sigma receptor
	EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.		Sigma receptor
T5969	Ditolylguanidine	DTG,Di-o-tolylguanidine,1,3-Di-o-tolylguanidine	Sigma receptor
	Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).		Sigma receptor
T1885	Siramesine hydrochloride	Lu 28-179 hydrochloride	Ferroptosis , Sigma receptor , lysosomal autophagy
	Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.		Ferroptosis , Sigma receptor , lysosomal autophagy
T3198L	PRE-084 hydrochloride		Sigma receptor
	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).		Sigma receptor
T4111	Blarcamesine hydrochloride	Anavex 2-73,AVex-73 hydrochloride,AE-37 hydrochloride	Sigma receptor
	Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).		Sigma receptor
T1865	S1RA	E-52862	Sigma receptor
	S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2 receptor (σ2R, Ki > 1000 nM).		Sigma receptor
T4229	S1RA hydrochloride	E-52862 hydrochloride	Sigma receptor
	S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).		Sigma receptor
T20797	NE-100 hydrochloride	NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl	Sigma receptor
	NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.		Sigma receptor
T3597	Cutamesine dihydrochloride	AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor
	Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr...		Sigma receptor
T4620	Siramesine	Lu 28-179	Sigma receptor
	Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram...		Sigma receptor
T13510	Sigma-LIGAND-1		Sigma receptor
	Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor.		Sigma receptor
T79499	KSK68		Histamine Receptor
	KSK68 is a potent dual sigma-1 and histamine H3 receptor antagonist with potential analgesic activity and high affinity for H3 receptors, sigma-1, sigma-2 receptors.KSK68 can be used in the study of pain related diseases...		Histamine Receptor
T79500	KSK94		Histamine Receptor
	KSK94 is a specific H3 receptor antagonist that inhibits H3, sigma-1, and sigma-2 receptors , with Ki values of 7.9, 2958, and 75.2 nM, respectively, and can be used to study injurious pain and neuropathic pain.		Histamine Receptor
T24885	Tiospirone	BMY 13859-1	Dopamine Receptor , 5-HT Receptor
	Tiospirone (BMY 13859-1 free base) is a 5-HT2 receptor antagonist and dopamine blocker that inhibits D2, 5-HT1a, 5-HT7, and sigma receptors.Tiospirone is used in the study of neurological disorders such as schizophrenia.		Dopamine Receptor , 5-HT Receptor
T1186L	Ifenprodil	RC 61-91,RC-61-91,RC61-91,RC 6191	Adrenergic Receptor , NMDAR
	Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibit...		Adrenergic Receptor , NMDAR
T21788	BD 1008 dihydrobromide		Sigma receptor
	BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, moderate affinity for sigma2 receptors.		Sigma receptor
T39211	PD 144418 oxalate		Sigma receptor
	PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes....		Sigma receptor
T22870	IPAG		Opioid Receptor
	IPAG is a potent σ-receptor antagonist (pKi=4.3). IPAG can induce cell apoptosis.		Opioid Receptor
T5389	Volinanserin	M 100907,MDL100907	5-HT Receptor
	Volinanserin (MDL100907) (MDL 100907) is a potent and selective antagonist of the serotonin receptor 5-HT2 (Ki: 0.36 nM) and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 adrenergic and sigma recepto...		5-HT Receptor
T4093	Fabomotizole hydrochloride	Afobazole hydrochloride,CM346 hydrochloride	MAO
	Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro...		MAO
T60835	SKF83959		Dopamine Receptor
	SKF83959, a benzazepine analog, is a selective and potent partial agonist of the dopamine D1 receptor with Ki values of 1.18, 7.56, 920, and 399 nM for rat D1, D5, D2, and D3 receptors, respectively.SKF83959 is a potent ...		Dopamine Receptor
T22904	L-745870 trihydrochloride	L-745,870 trihydrochloride	Dopamine Receptor , Sigma receptor , 5-HT Receptor , Adrenergic Receptor
	L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
T7352	Pridopidine	ACR16,ASP2314,FR310826	Dopamine Receptor
	Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.		Dopamine Receptor
T11799	L-745870 hydrochloride		Dopamine Receptor
	L-745870 hydrochloride has excellent brain penetration. L-745870 hydrochloride is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM, and considerably weaker D2 recept...		Dopamine Receptor
T79500L	KSK94 FA	KSK94 FA(2566716-07-0 Free base)	Histamine Receptor
	KSK94 FA is a potent histamine H3 receptor antagonist that inhibits H3 receptors and is used in the study of neuropathic pain and obesity.		Histamine Receptor
T25585	KSCM-11	KSCM11
	KSCM-11 is a sigma receptor ligand.
T25586	KSCM-5	KSCM 5,KSCM5
	KSCM-5 is a sigma receptor ligand.
T25584	KSCM-1	KSCM 1
	KSCM-1 is a selective sigma-1 receptor ligand.
T70809	BD 1008 Free Base
	BD 1008 Free Base is a selective sigma receptor antagonist, with a reported binding affinity of Kᵢ = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor.
T26245	SW43	SW-43,SW 43
	SW43 is a selective ligand of sigma-2 receptor.
T24334	L 687384	L687,384,L 687,384,L-687,384,L-687384,L687384
	L 687384 is a high-affinity ligand of sigma receptor.
T63048	Sigma-LIGAND-1 hydrochloride
	Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand that acts at the DTG (IC50: 16 nM) and PPP (IC50: 19 nM) sites. Sigma-LIGAND-1 hydrochloride is able to act on the dopamine D2 receptor (Ki: 4000 nM).
T71949	CM304
	CM304 is a highly selective sigma-1 receptor antagonist.
T1885L	Siramesine Fumarate	LU-28179,LU-28-179,LU 28 179
	Siramesine Fumarate, a sigma receptor agonist, is used potentially for the treatment of generalized anxiety disorder.
T10093L	E1R		Others
	E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity.		Others
T24712	Rimcazole
	Rimcazole is a sigma receptor antagonist. It also binds to the dopamine transporter and inhibiting dopamine uptake.

Compounds

Sigma-1 receptor antagonist 1

T12910

Synonym:

Target: Sigma receptor

Sigma-1 receptor antagonist 2

T12911

Synonym:

Target: Sigma receptor

Sigma-1 receptor antagonist 3

T12912

Synonym:

Target: Sigma receptor, HER

Sigma-2 receptor antagonist 1

Target: Sigma receptor

σ1 Receptor antagonist-1

T9244

Synonym:

Target: Sigma receptor

BD1063 dhydrochloride

T7488

Synonym: BD1063

Target: Sigma receptor

Sigma-1 receptor antagonist 5

T78734

Synonym:

Target: Sigma receptor

Dimemorfan phosphate

T5027

Synonym: 3,17-dimethylmorphinan

Target: Sigma receptor

Blonanserin

T1180

Synonym: AD-5423

Target: Dopamine Receptor, Sigma receptor, 5-HT Receptor, Adrenergic Receptor

Glycerol phenylbutyrate

T15393

Synonym: HPN-100

Target: Sigma receptor

Blarcamesine

T7780

Synonym: AE-37,AVex-73

Target: AChR

Roluperidone

T15034

Synonym: CYR-101,MIN-101,MT-210

Target: Sigma receptor, 5-HT Receptor

BD-1047 dihydrobromide

T1740

Synonym: BD1047.2HBr

Target: Sigma receptor

EST64454 hydrochloride

T8834

Synonym: EST64454

Target: Sigma receptor

Ditolylguanidine

T5969

Synonym: DTG,Di-o-tolylguanidine,1,3-Di-o-tolylguanidine

Target: Sigma receptor

Siramesine hydrochloride

T1885

Synonym: Lu 28-179 hydrochloride

Target: Ferroptosis, Sigma receptor, lysosomal autophagy

PRE-084 hydrochloride

T3198L

Synonym:

Target: Sigma receptor

Blarcamesine hydrochloride

T4111

Synonym: Anavex 2-73,AVex-73 hydrochloride,AE-37 hydrochloride

Target: Sigma receptor

S1RA

T1865

Synonym: E-52862

Target: Sigma receptor

S1RA hydrochloride

T4229

Synonym: E-52862 hydrochloride

Target: Sigma receptor

NE-100 hydrochloride

T20797

Synonym: NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl

Target: Sigma receptor

Cutamesine dihydrochloride

T3597

Synonym: AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride

Target: Sigma receptor

Siramesine

T4620

Synonym: Lu 28-179

Target: Sigma receptor

Sigma-LIGAND-1

T13510

Synonym:

Target: Sigma receptor

KSK68

T79499

Synonym:

Target: Histamine Receptor

KSK94

T79500

Synonym:

Target: Histamine Receptor

Tiospirone

T24885

Synonym: BMY 13859-1

Target: Dopamine Receptor, 5-HT Receptor

Ifenprodil

T1186L

Synonym: RC 61-91,RC-61-91,RC61-91,RC 6191

Target: Adrenergic Receptor, NMDAR

BD 1008 dihydrobromide

T21788

Synonym:

Target: Sigma receptor

PD 144418 oxalate

T39211

Synonym:

Target: Sigma receptor

IPAG

T22870

Synonym:

Target: Opioid Receptor

Volinanserin

T5389

Synonym: M 100907,MDL100907

Target: 5-HT Receptor

Fabomotizole hydrochloride

T4093

Synonym: Afobazole hydrochloride,CM346 hydrochloride

Target: Dopamine Receptor

L-745870 trihydrochloride

T22904

Synonym: L-745,870 trihydrochloride

Target: Dopamine Receptor, Sigma receptor, 5-HT Receptor, Adrenergic Receptor

Pridopidine

T7352

Synonym: ACR16,ASP2314,FR310826

Target: Dopamine Receptor

L-745870 hydrochloride

T11799

Synonym:

Target: Dopamine Receptor

KSK94 FA

T79500L

Synonym: KSK94 FA(2566716-07-0 Free base)

Target: Histamine Receptor

Synonym: KSCM 5,KSCM5

Synonym: L687,384,L 687,384,L-687,384,L-687384,L687384

Target:

Sigma-LIGAND-1 hydrochloride

Synonym: LU-28179,LU-28-179,LU 28 179

Cat No.	Product Name
L2610	Neurotransmitter Receptor Compound Library		1513 compounds
	A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；

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