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Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T22026 AGK7 304896-21-7 98.31%
AGK7
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3,...
T12919 SIRT-IN-2 1431411-66-3 98.26%
SIRT-IN-2
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
T3S0175 Gardenia yellow 94238-00-3 98.24%
Gardenia yellow
Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.
T12921 SIRT5 inhibitor 1 2166487-21-2 98.06%
SIRT5 inhibitor 1
SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases....
T5S1133 Ganoderic acid D 108340-60-9 98.06%
Ganoderic acid D
1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervi...
T1887 Inauhzin 309271-94-1 97.69%
Inauhzin
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells wi...
T3953 Salermide 1105698-15-4 97.62%
Salermide
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
T8346 SRT 1460 925432-73-1 97.62%
SRT 1460
SRT 1460 is a SIRT1 activator.
T2160 Suramin Sodium Salt 129-46-4 97.47%
Suramin Sodium Salt
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
T22094 JGB1741 1256375-38-8 97.24%
JGB1741
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleava...
T9320 YK-3-237 1215281-19-8 96.38%
YK-3-237
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative e...
T4108 3-TYP 120241-79-4 100.00%
3-TYP
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
T28543 RK-9123016 955900-27-3 100%
RK-9123016
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
T8480 Tenovin-6 Hydrochloride 1011301-29-3 100%
Tenovin-6 Hydrochloride
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
T1818 Tenovin-6 1011557-82-6 100%
Tenovin-6
Tenovin-6 is a p53 transcriptional activity agonist.
T64529 MDL-800 2275619-53-7 100%
MDL-800
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
T16932 SRT 2183 1001908-89-9 100%
SRT 2183
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
T50080 MC2184 74901-20-5
MC2184
MC2184 is the inhibitor of human recombinant SIRT1.
T2750 Ginkgolide C 15291-76-6
Ginkgolide C
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
T77697 BML-278 120533-76-8 98%
BML-278
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can...
AGK7
T22026
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3,...
SIRT-IN-2
T12919
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
Gardenia yellow
T3S0175
Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.
SIRT5 inhibitor 1
T12921
SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases....
Ganoderic acid D
T5S1133
1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervi...
Inauhzin
T1887
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells wi...
Salermide
T3953
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
SRT 1460
T8346
SRT 1460 is a SIRT1 activator.
Suramin Sodium Salt
T2160
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
JGB1741
T22094
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleava...
YK-3-237
T9320
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative e...
3-TYP
T4108
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
RK-9123016
T28543
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
Tenovin-6 Hydrochloride
T8480
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
Tenovin-6
T1818
Tenovin-6 is a p53 transcriptional activity agonist.
MDL-800
T64529
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
SRT 2183
T16932
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
MC2184
T50080
MC2184 is the inhibitor of human recombinant SIRT1.
Ginkgolide C
T2750
Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.
BML-278
T77697
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can...
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