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Membrane transporter/Ion channel Sodium Channel

Sodium Channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
Cat No. product name
T0008 Phenytoin sodium Phenytoin sodium is an inactive stabilizer for voltage-gated sodium channel .
T0012 Cinchonine Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local nar...
T0018 Procainamide hydrochloride Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procain...
T0024 Primidone Primidone is an anticonvulsant of the pyrimidinedione class.
T0029 Procaine Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral...
T0030 Bupivacaine hydrochloride Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivacaine reversibly binds to specific sodium ion channels in the neuronal membran...
T0044 Oxethazaine Oxethazaine, a topical anesthetic, is used to prevent acid-induced esophageal pain.
T0167 Vinpocetine Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T0175L Amiloride hydrochloride dihydrate Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negat...
T0207 Ranolazine dihydrochloride Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), an...
T0222 Proparacaine hydrochloride Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride ...
T0249 Acecainide N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
T0266 Quinidine hydrochloride Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and dec...
T0267 Zonisamide Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydr...
T0275 Meticrane Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
T0349 Riluzole Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC L...
T0364 Dibucaine Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
T0364L Dibucaine hydrochloride Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
T0378 Oxybuprocaine hydrochloride Oxybuprocaine hydrochloride, a local anesthetic, is used especially in otolaryngology and ophthalmology.
T0386 Ropivacaine hydrochloride Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
T0386L Ropivacaine Ropivacaine is a local anaesthetic drug belonging to the amino amide group.
T0440 Oxcarbazepine Oxcarbazepine is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activi...
T0460 Pramoxine hydrochloride Pramocaine hydrochloride, a topical anesthetic, is served as an antipruritic.
T0470 Nefopam hydrochloride Nefopam Hydrochloride is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
T0511 Tolperisone hydrochloride Tolperisone hydrochloride, a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by ...
T0792 (-)-Sparteine sulfate pentahydrate Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T0796 Propitocaine hydrochloride Prilocaine hydrochloride is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing ...
T0802 Procaine hydrochloride
T0843 Ademine Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
T0866 Propafenone Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythm...
T0916 Butyl 4-aminobenzoate Butamben is a long-duration local anesthetic used for the treatment of chronic pain.
T0924 Benzocaine Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T0939 Phenytoin Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium e...
T0943 Carbamazepine Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts i...
T0946 Mepivacaine hydrochloride Mepivacaine Hydrochloride is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.
T1046 Mexiletine hydrochloride Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine....
T1073 Dronedarone hydrochloride Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
T10757L Cenobamate Cenobamate, a sodium channel blocker, enhances GABAergic transmission. It has a potential to be a versatile CNS drug.
T1144 Lidocaine hydrochloride Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonge...
T1144L Lidocaine Hydrochloride hydrate Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.
T1198 Tetracaine hydrochloride Tetracaine hydrochloride (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topic...
T12608 QX-314 chloride QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
T12951 Sodium Channel inhibitor 2 Sodium Channel inhibitor 2 is a blocker of sodium channel.
T1308 Orphenadrine hydrochloride Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T13177 Tocainide hydrochloride Tocainide hydrochloride is a blocker of the sodium channel and used for the treatment of tinnitus.
T1320 Disopyramide A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) w...
T1332 Permethrin Permethrin is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
T1334 Hydroquinidine Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
T13830 Propoxycaine hydrochloride Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.
T1386 Phenazopyridine hydrochloride Phenazopyridine Hydrochloride is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, inte...
T1389 Dyclonine hydrochloride Dyclonine, an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
T15260 Evenamide Evenamide is a sodium channel blocker. It shows efficacy in a broad spectrum of rodent models of psychosis, depression, mania, and aggressiveness.
T16707 QX-314 bromide QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel.
T16887 Sipatrigine Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
T1787 Levobupivacaine Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. ...
T19644 Benzonatate Benzonatate is an antagonist of sodium channel protein.
T2024 A803467 A-803467 is a selective NaV1.8 channel blocker.
T2049 GS967 GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
T2131 Articaine HCl Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
T2139 Butacaine Butacaine is a local anesthetic.
T2173 Veratridine Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
T2192 Indazole Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound. Indazole derivatives display a broad variety of biological activ...
T2342 CNV1014802 Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
T2391 Camostat mesilate Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
T2523 Rufinamide Rufinamide, a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
T2806 Lappaconitine Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
T2S0820 Karanjin
T3029 Sparteine sulfate Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T3285 Eslicarbazepine Acetate Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onse...
T3364 Veratramine Veratramine(NSC17821; NSC23880) is a potent signal transduction inhibitor for treating tumors.
T4490 PF01247324 PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
T4539 Nicainoprol Nicainoprol is a fast-sodium-channel blocking drug, which is a potent antiarrhythmic agent.
T4550 Ajmaline Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachy...
T4699 Hexamethylene amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.01...
T5319 Rimeporide Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
T5324 BI 01383298 BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
T5333 Rimeporide hydrochloride Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
T5850 Benzamil (hydrochloride) Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane...
T6234 Ambroxol hydrochloride Ambroxol hydrochloride is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually admi...
T6541 Ibutilide Fumarate Ibutilide Fumarate is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predomina...
T6566 Levobupivacaine HCl Levobupivacaine HCl is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local ...
T6782 Benzocaine hydrochloride Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T6782L Benzocaine xHCl(94-09-7(free base)) Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).
T6953 Prilocaine Prilocaine is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
T6955 Propafenone HCl Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
T7056 Dronedarone Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T7064 Valproic Acid Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mo...
T7066 Fosphenytoin sodium Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
T7182 Metaflumizone Metaflumizone is a sodium channel blocker insecticide.
T7190 Actein Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblas...
T7219 Flecainide (acetate) Flecainide (acetate) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
T7336 ICA-121431 ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or N...
T7349 Ralfinamide Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
T7547 Ralfinamide mesylate Ralfinamide mesylate is an orally available Na+ channel blocker.
T7811 Pilsicainide HCl Pilsicainide HCl is a pure sodium channel blocker
T8299 Dimethyl lithospermate B Dimethyl lithospermate B is a selective Na+ channel agonist.
T8444 N-Me-aminopyrimidinone9 N-Me-aminopyrimidinone9 is a sodium channel antagonist
T8711 PF-05186462 PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
TCA2511 11Beta-hydroxyprogesterone The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro...
TN1740 Homoeriodictyol Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can i...
TN2054 Periplocymarin Periplocymarin, a cardiac glycoside, has potential anti-cancer activity.
TN2239 Strictosamide Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
TN2306 Wilfordine Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
TN3042 4-Hydroxycinnamamide 4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
TN3910 Ecdysone Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
TN4276 Isocudraniaxanthone B Isocudraniaxanthone B may have antimalarial activity.
TN4697 Odoroside H Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
TN5060 Stauntosaponin A Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
TN5141 Thevetin B Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors.
TN5234 Vindorosine Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular s...
TQ0011 PF-06869206 PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
TQ0014 GNE-131 GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
TQ0157 EIPA EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
Phenytoin sodium
T0008CAS 630-93-3
Phenytoin sodium is an inactive stabilizer for voltage-gated sodium channel .
Cinchonine
T0012CAS 118-10-5
Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local nar...
Procainamide hydrochloride
T0018CAS 614-39-1
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procain...
Primidone
T0024CAS 125-33-7
Primidone is an anticonvulsant of the pyrimidinedione class.
Procaine
T0029CAS 59-46-1
Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral...
Bupivacaine hydrochloride
T0030CAS 18010-40-7
Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivacaine reversibly binds to specific sodium ion channels in the neuronal membran...
Oxethazaine
T0044CAS 126-27-2
Oxethazaine, a topical anesthetic, is used to prevent acid-induced esophageal pain.
Vinpocetine
T0167CAS 42971-09-5
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
Amiloride hydrochloride dihydrate
T0175LCAS 17440-83-4
Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negat...
Ranolazine dihydrochloride
T0207CAS 95635-56-6
Ranolazine(RS-43285), an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), an...
Proparacaine hydrochloride
T0222CAS 5875-06-9
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride ...
Acecainide
T0249CAS 32795-44-1
N-Acetylprocainamide, the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
Quinidine hydrochloride
T0266CAS 6151-40-2
Quinidine is an optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. It prolongs cellular action potential and dec...
Zonisamide
T0267CAS 68291-97-4
Zonisamide, a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydr...
Meticrane
T0275CAS 1084-65-7
Meticrane is a sulphonamide-derivative with thiazide-like diuretic activity.
Riluzole
T0349CAS 1744-22-5
Riluzole is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC L...
Dibucaine
T0364CAS 85-79-0
Dibucaine, a local anesthetic of the amide type, is now usually used for surface anesthesia.
Dibucaine hydrochloride
T0364LCAS 61-12-1
Dibucaine hydrochloride, a long-acting local amide anestheticsis, is usually used for surface anesthesia.
Oxybuprocaine hydrochloride
T0378CAS 5987-82-6
Oxybuprocaine hydrochloride, a local anesthetic, is used especially in otolaryngology and ophthalmology.
Ropivacaine hydrochloride
T0386CAS 98717-15-8
Ropivacaine hydrochloride is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
Ropivacaine
T0386LCAS 84057-95-4
Ropivacaine is a local anaesthetic drug belonging to the amino amide group.
Oxcarbazepine
T0440CAS 28721-07-5
Oxcarbazepine is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activi...
Pramoxine hydrochloride
T0460CAS 637-58-1
Pramocaine hydrochloride, a topical anesthetic, is served as an antipruritic.
Nefopam hydrochloride
T0470CAS 23327-57-3
Nefopam Hydrochloride is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
Tolperisone hydrochloride
T0511CAS 3644-61-9
Tolperisone hydrochloride, a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by ...
(-)-Sparteine sulfate pentahydrate
T0792CAS 6160-12-9
Sparteine sulfate pentahydrate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
Propitocaine hydrochloride
T0796CAS 1786-81-8
Prilocaine hydrochloride is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing ...
Procaine hydrochloride
T0802CAS 51-05-8
Ademine
T0843CAS 396-01-0
Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
Propafenone
T0866CAS 54063-53-5
Propafenone is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythm...
Butyl 4-aminobenzoate
T0916CAS 94-25-7
Butamben is a long-duration local anesthetic used for the treatment of chronic pain.
Benzocaine
T0924CAS 94-09-7
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
Phenytoin
T0939CAS 57-41-0
Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium e...
Carbamazepine
T0943CAS 298-46-4
Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts i...
Mepivacaine hydrochloride
T0946CAS 1722-62-9
Mepivacaine Hydrochloride is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.
Mexiletine hydrochloride
T1046CAS 5370-01-4
Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine....
Dronedarone hydrochloride
T1073CAS 141625-93-6
Dronedarone hydrochloride is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.
Cenobamate
T10757LCAS 913088-80-9
Cenobamate, a sodium channel blocker, enhances GABAergic transmission. It has a potential to be a versatile CNS drug.
Lidocaine hydrochloride
T1144CAS 73-78-9
Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonge...
Lidocaine Hydrochloride hydrate
T1144LCAS 6108-05-0
Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.
Tetracaine hydrochloride
T1198CAS 136-47-0
Tetracaine hydrochloride (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topic...
QX-314 chloride
T12608CAS 5369-03-9
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
Sodium Channel inhibitor 2
T12951CAS 653573-60-5
Sodium Channel inhibitor 2 is a blocker of sodium channel.
Orphenadrine hydrochloride
T1308CAS 341-69-5
Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Tocainide hydrochloride
T13177CAS 71395-14-7
Tocainide hydrochloride is a blocker of the sodium channel and used for the treatment of tinnitus.
Disopyramide
T1320CAS 3737-09-5
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) w...
Permethrin
T1332CAS 52645-53-1
Permethrin is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
Hydroquinidine
T1334CAS 1435-55-8
Dihydroquinidine is an organic compound, used as an antiarrhythmic agent.
Propoxycaine hydrochloride
T13830CAS 550-83-4
Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.
Phenazopyridine hydrochloride
T1386CAS 136-40-3
Phenazopyridine Hydrochloride is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, inte...
Dyclonine hydrochloride
T1389CAS 536-43-6
Dyclonine, an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
Evenamide
T15260CAS 1092977-61-1
Evenamide is a sodium channel blocker. It shows efficacy in a broad spectrum of rodent models of psychosis, depression, mania, and aggressiveness.
QX-314 bromide
T16707CAS 24003-58-5
QX-314 bromide is a blocker of the membrane-impermeable permanently charged sodium channel.
Sipatrigine
T16887CAS 130800-90-7
Sipatrigine is a glutamate release inhibitor and voltage-dependent sodium channel.
Levobupivacaine
T1787CAS 27262-47-1
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. ...
Benzonatate
T19644CAS 104-31-4
Benzonatate is an antagonist of sodium channel protein.
A803467
T2024CAS 944261-79-4
A-803467 is a selective NaV1.8 channel blocker.
GS967
T2049CAS 1262618-39-2
GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).
Articaine HCl
T2131CAS 23964-57-0
Articaine hydrochloride is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.
Butacaine
T2139CAS 149-16-6
Butacaine is a local anesthetic.
Veratridine
T2173CAS 71-62-5
Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
Indazole
T2192CAS 271-44-3
Indazole, also called benzpyrazole or isoindazone, is a heterocyclic aromatic organic compound. Indazole derivatives display a broad variety of biological activ...
CNV1014802
T2342CAS 934240-30-9
Raxatrigine has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
Camostat mesilate
T2391CAS 59721-29-8
Camostat is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
Rufinamide
T2523CAS 106308-44-5
Rufinamide, a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
Lappaconitine
T2806CAS 32854-75-4
Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
Karanjin
T2S0820CAS 521-88-0
Sparteine sulfate
T3029CAS 299-39-8
Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
Eslicarbazepine Acetate
T3285CAS 236395-14-5
Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onse...
Veratramine
T3364CAS 60-70-8
Veratramine(NSC17821; NSC23880) is a potent signal transduction inhibitor for treating tumors.
PF01247324
T4490CAS 875051-72-2
PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
Nicainoprol
T4539CAS 76252-06-7
Nicainoprol is a fast-sodium-channel blocking drug, which is a potent antiarrhythmic agent.
Ajmaline
T4550CAS 4360-12-7
Ajmaline is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachy...
Hexamethylene amiloride
T4699CAS 1428-95-1
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.01...
Rimeporide
T5319CAS 187870-78-6
Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
BI 01383298
T5324CAS 2227549-00-8
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
Rimeporide hydrochloride
T5333CAS 187870-95-7
Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
Benzamil (hydrochloride)
T5850CAS 2898-76-2
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane...
Ambroxol hydrochloride
T6234CAS 23828-92-4
Ambroxol hydrochloride is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually admi...
Ibutilide Fumarate
T6541CAS 122647-32-9
Ibutilide Fumarate is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predomina...
Levobupivacaine HCl
T6566CAS 27262-48-2
Levobupivacaine HCl is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local ...
Benzocaine hydrochloride
T6782CAS 23239-88-5
Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
Benzocaine xHCl(94-09-7(free base))
T6782LCAS T6782L
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).
Prilocaine
T6953CAS 721-50-6
Prilocaine is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.
Propafenone HCl
T6955CAS 34183-22-7
Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
Dronedarone
T7056CAS 141626-36-0
Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
Valproic Acid
T7064CAS 99-66-1
Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mo...
Fosphenytoin sodium
T7066CAS 92134-98-0
Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
Metaflumizone
T7182CAS 139968-49-3
Metaflumizone is a sodium channel blocker insecticide.
Actein
T7190CAS 18642-44-9
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblas...
Flecainide (acetate)
T7219CAS 54143-56-5
Flecainide (acetate) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
ICA-121431
T7336CAS 313254-51-2
ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or N...
Ralfinamide
T7349CAS 133865-88-0
Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
Ralfinamide mesylate
T7547CAS 202825-45-4
Ralfinamide mesylate is an orally available Na+ channel blocker.
Pilsicainide HCl
T7811CAS 88069-49-2
Pilsicainide HCl is a pure sodium channel blocker
Dimethyl lithospermate B
T8299CAS 875313-64-7
Dimethyl lithospermate B is a selective Na+ channel agonist.
N-Me-aminopyrimidinone9
T8444CAS 1356834-62-2
N-Me-aminopyrimidinone9 is a sodium channel antagonist
PF-05186462
T8711CAS 1235406-03-7
PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
11Beta-hydroxyprogesterone
TCA2511CAS 600-57-7
The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro...
Homoeriodictyol
TN1740CAS 446-71-9
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can i...
Periplocymarin
TN2054CAS 32476-67-8
Periplocymarin, a cardiac glycoside, has potential anti-cancer activity.
Strictosamide
TN2239CAS 23141-25-5
Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
Wilfordine
TN2306CAS 37239-51-3
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
4-Hydroxycinnamamide
TN3042CAS 194940-15-3
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
Ecdysone
TN3910CAS 3604-87-3
Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. A nctional Bombyx Ecdysone receptor binds to EcRE-D ...
Isocudraniaxanthone B
TN4276CAS 199851-52-0
Isocudraniaxanthone B may have antimalarial activity.
Odoroside H
TN4697CAS 18810-25-8
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
Stauntosaponin A
TN5060CAS 1417887-91-2
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
Thevetin B
TN5141CAS 27127-79-3
Thevetin B is a cardiac glycoside. Thevetin A and thevetin B are Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors.
Vindorosine
TN5234CAS 5231-60-7
Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular s...
PF-06869206
TQ0011CAS 2227425-05-8
PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
GNE-131
TQ0014CAS 1629063-81-5
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
EIPA
TQ0157CAS 1154-25-2
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.