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Sodium Channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T80169 ProTx-III 98%
ProTx-III
ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a selective and potent inhibitor of the voltage-gated sodium cha...
T80176 Crotamine 98%
Crotamine
Crotamine, a 42 amino acid toxin featuring three disulfide bridges, functions as a Na+ channel modulator with analgesic properties. This compound interacts with ...
T80177 Phlotoxin-1 98%
Phlotoxin-1
Phlotoxin-1 (PhlTx1), a 34-amino acid peptide featuring three disulfide bridges, is derived from the Phlogiellus genus spider and acts as an antinociceptive agen...
T80178 Dc1a 98%
Dc1a
Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).
T80179 GrTx1 98%
GrTx1
GrTx1, a peptide toxin derived from Grammostola rosea spider venom, selectively inhibits sodium channels Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, with...
T80181 MitTx-alpha 98%
MitTx-alpha
MitTx-alpha, a component of the complex MitTx, acts as a powerful and enduring agonist specifically targeting acid-sensing ion channels (ASICs), with a pronounce...
T80182 MitTx 98%
MitTx
MitTx, a complex consisting of MitTx-α and MitTx-β, serves as an ASIC1 channel activator, demonstrating EC50 values of 9.4 nM and 23 nM for the ASIC1a and ASIC1b...
T80184 GsAF-II 98%
GsAF-II
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodium chann...
T80186 Hainantoxin-III 1809149-40-3 98%
Hainantoxin-III
Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting both tetr...
T80188 Hm1a 98%
Hm1a
Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1]...
T80189 Hainantoxin-IV 651782-02-4 98%
Hainantoxin-IV
Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and Lys32 being critical residues for b...
T80230 μ-Conotoxin Sx IIIA 1400096-00-5 98%
μ-Conotoxin Sx IIIA
μ-Conotoxin Sx IIIA is a biologically active peptide that functions as a blocker of NaV1.4 channels.
T80425 Jingzhaotoxin-V 98%
Jingzhaotoxin-V
Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium ...
T80426 Jingzhaotoxin-IX 98%
Jingzhaotoxin-IX
Jingzhaotoxin-IX is a C-terminally amidated peptide neurotoxin consisting of 35 amino acid residues. It inhibits both tetrodotoxin-resistant and tetrodotoxin-sen...
T80427 Jingzhaotoxin-II 98%
Jingzhaotoxin-II
Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodium channels...
T80428 Jingzhaotoxin-34 98%
Jingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neurons wi...
T80429 π-TRTX-Hm3a 98%
π-TRTX-Hm3a
π-TRTX-Hm3a, a 37-amino acid peptide derived from the venom of the Togo starburst tarantula (Heteroscodra maculata), selectively inhibits the acid-sensing ion ch...
T80430 δ-Theraphotoxin-Hm1b 98%
δ-Theraphotoxin-Hm1b
δ-Theraphotoxin-Hm1b, a 42-amino acid peptide derived from the Togo starburst tarantula (Heteroscodra maculata) venom, selectively inhibits the inactivation of N...
T80431 δ-Theraphotoxin-Hm1a toxin 98%
δ-Theraphotoxin-Hm1a toxin
δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications in irritable bowel syndrome research [1...
T80432 δ-Buthitoxin-Hj2a 98%
δ-Buthitoxin-Hj2a
δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].
ProTx-III
T80169
ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a selective and potent inhibitor of the voltage-gated sodium cha...
Crotamine
T80176
Crotamine, a 42 amino acid toxin featuring three disulfide bridges, functions as a Na+ channel modulator with analgesic properties. This compound interacts with ...
Phlotoxin-1
T80177
Phlotoxin-1 (PhlTx1), a 34-amino acid peptide featuring three disulfide bridges, is derived from the Phlogiellus genus spider and acts as an antinociceptive agen...
Dc1a
T80178
Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).
GrTx1
T80179
GrTx1, a peptide toxin derived from Grammostola rosea spider venom, selectively inhibits sodium channels Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, with...
MitTx-alpha
T80181
MitTx-alpha, a component of the complex MitTx, acts as a powerful and enduring agonist specifically targeting acid-sensing ion channels (ASICs), with a pronounce...
MitTx
T80182
MitTx, a complex consisting of MitTx-α and MitTx-β, serves as an ASIC1 channel activator, demonstrating EC50 values of 9.4 nM and 23 nM for the ASIC1a and ASIC1b...
GsAF-II
T80184
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodium chann...
Hainantoxin-III
T80186
Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting both tetr...
Hm1a
T80188
Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1]...
Hainantoxin-IV
T80189
Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and Lys32 being critical residues for b...
μ-Conotoxin Sx IIIA
T80230
μ-Conotoxin Sx IIIA is a biologically active peptide that functions as a blocker of NaV1.4 channels.
Jingzhaotoxin-V
T80425
Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium ...
Jingzhaotoxin-IX
T80426
Jingzhaotoxin-IX is a C-terminally amidated peptide neurotoxin consisting of 35 amino acid residues. It inhibits both tetrodotoxin-resistant and tetrodotoxin-sen...
Jingzhaotoxin-II
T80427
Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodium channels...
Jingzhaotoxin-34
T80428
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neurons wi...
π-TRTX-Hm3a
T80429
π-TRTX-Hm3a, a 37-amino acid peptide derived from the venom of the Togo starburst tarantula (Heteroscodra maculata), selectively inhibits the acid-sensing ion ch...
δ-Theraphotoxin-Hm1b
T80430
δ-Theraphotoxin-Hm1b, a 42-amino acid peptide derived from the Togo starburst tarantula (Heteroscodra maculata) venom, selectively inhibits the inactivation of N...
δ-Theraphotoxin-Hm1a toxin
T80431
δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications in irritable bowel syndrome research [1...
δ-Buthitoxin-Hj2a
T80432
δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].
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TargetMol