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Sodium Channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T12655 (Rac)-AMG8379 1641574-26-6 99.6%
(Rac)-AMG8379
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.
T0460 Pramocaine hydrochloride 637-58-1 99.57%
Pramocaine hydrochloride
Pramocaine hydrochloride (Pramoxine HCl), a topical anesthetic, is served as an antipruritic.
T0386 Ropivacaine hydrochloride 98717-15-8 99.55%
Ropivacaine hydrochloride
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity....
T6234 Ambroxol hydrochloride 23828-92-4 99.55%
Ambroxol hydrochloride
Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is ...
T22675 Co 102862 181144-66-1 99.54%
Co 102862
Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.
T1308 Orphenadrine hydrochloride 341-69-5 99.54%
Orphenadrine hydrochloride
Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T80626 VGSCs-IN-1 1204296-79-6 99.50%
VGSCs-IN-1
VGSCs-IN-1 is a potent VGSC inhibitor, a 2-piperazine analog of Riluzole that exhibits good blocking activity on Nav1.4.VGSCs-IN-1 can be used to study cellular ...
T7064 Valproic Acid 99-66-1 99.49%
Valproic Acid
Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. C...
T1389 Dyclonine hydrochloride 536-43-6 99.49%
Dyclonine hydrochloride
Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
T9647 GX 201 1788071-27-1 99.46%
GX 201
GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.
T0364L Dibucaine hydrochloride 61-12-1 99.45%
Dibucaine hydrochloride
Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.
T16897 SM-6586 103898-38-0 99.43%
SM-6586
SM-6586 is a potent calcium channel antagonist with inhibitory effects on Na+/H+ and Na+/Ca2+ exchange channels, and can be used in the study of cerebrovascular ...
T7502L PF 05089771 1235403-62-9 99.42%
PF 05089771
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that...
T0862 Diphenidol hydrochloride 3254-89-5 99.42%
Diphenidol hydrochloride
Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
T79835 Aneratrigine hydrochloride 2097163-75-0 99.39%
Aneratrigine hydrochloride
Aneratrigine hydrochloride is a sodium channel protein type 9 subunit blocker that may be used for the prevention or treatment of sodium channel blocker-related ...
T2342 Raxatrigine 934240-30-9 99.39%
Raxatrigine
Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
T68599 Orphenadrine 83-98-7 99.38%
Orphenadrine
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producin...
T8711 PF-05186462 1235406-03-7 99.37%
PF-05186462
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
T22361 Mepivacaine 96-88-8 99.35%
Mepivacaine
Mepivacaine (Carbocaine) is an amide compound for local anaesthesia that causes transient loss of self-consciousness in humans or animals. mepivacaine acts by bi...
T12181 NaV1.7 inhibitor-1 1494585-79-3 99.35%
NaV1.7 inhibitor-1
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
(Rac)-AMG8379
T12655
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.
Pramocaine hydrochloride
T0460
Pramocaine hydrochloride (Pramoxine HCl), a topical anesthetic, is served as an antipruritic.
Ropivacaine hydrochloride
T0386
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity....
Ambroxol hydrochloride
T6234
Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is ...
Co 102862
T22675
Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.
Orphenadrine hydrochloride
T1308
Orphenadrine hydrochloride (Mephenamin) is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
VGSCs-IN-1
T80626
VGSCs-IN-1 is a potent VGSC inhibitor, a 2-piperazine analog of Riluzole that exhibits good blocking activity on Nav1.4.VGSCs-IN-1 can be used to study cellular ...
Valproic Acid
T7064
Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. C...
Dyclonine hydrochloride
T1389
Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
GX 201
T9647
GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.
Dibucaine hydrochloride
T0364L
Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.
SM-6586
T16897
SM-6586 is a potent calcium channel antagonist with inhibitory effects on Na+/H+ and Na+/Ca2+ exchange channels, and can be used in the study of cerebrovascular ...
PF 05089771
T7502L
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that...
Diphenidol hydrochloride
T0862
Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
Aneratrigine hydrochloride
T79835
Aneratrigine hydrochloride is a sodium channel protein type 9 subunit blocker that may be used for the prevention or treatment of sodium channel blocker-related ...
Raxatrigine
T2342
Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
Orphenadrine
T68599
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producin...
PF-05186462
T8711
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
Mepivacaine
T22361
Mepivacaine (Carbocaine) is an amide compound for local anaesthesia that causes transient loss of self-consciousness in humans or animals. mepivacaine acts by bi...
NaV1.7 inhibitor-1
T12181
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
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TargetMol