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Src

Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in invertebrates such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellates, but the SrcA and SrcB subfamilies are specific to vertebrates. Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T9017 HPK1-IN-2 2056122-11-1 99.62%
HPK1-IN-2
HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hema...
T22306 DGY-06-116 T22306 99.6%
DGY-06-116
DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.
T6227 Benidipine hydrochloride 91599-74-5 99.56%
Benidipine hydrochloride
Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.
T9002 SquarunkinA 2101958-02-3 99.52%
squarunkinA
squarunkinA is a novel modulator of the UNC119-Cargo Interaction, potently and selectively inhibiting the binding of a myristoylated peptide representing the N-t...
T4597 UM-164 903564-48-7 99.52%
UM-164
UM-164 (DAS-DFGO-II) is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164 also potently inhibits p38α and p38β.
TQ0132 A 419259 trihydrochloride 1435934-25-0 99.47%
A 419259 trihydrochloride
A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).
T1812 KX1-004 518058-84-9 99.42%
KX1-004
KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.
T15675 Tirbanibulin Mesylate 1080645-95-9 99.42%
Tirbanibulin Mesylate
Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
T11916 Lyn-IN-1 887650-05-7 99.33%
Lyn-IN-1
Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and Lyn
T1754 ZM 306416 690206-97-4 99.31%
ZM 306416
ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).
T3063 PD173955 260415-63-2 99.28%
PD173955
PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC...
T16760 RK-24466 213743-31-8 99.26%
RK-24466
RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.
T23127 PD-161570 192705-80-9 99.23%
PD-161570
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c...
T8995 NCGC00262650 344359-25-7 99.23%
NCGC00262650
NCGC00262650 is an inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity.
T2070 Agerafenib 1188910-76-0 99.23%
Agerafenib
Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.
T6920 ON123300 1357470-29-1 99.22%
ON123300
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
T13824 PP58 212391-58-7 99.21%
PP58
PP58 is an inhibitor of PDGFR, FGFR and Src family.
T2153 1-NM-PP1 221244-14-0 99.2%
1-NM-PP1
1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
T6419 BMS-536924 468740-43-4 99.19%
BMS-536924
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for ...
T2415 PP121 1092788-83-4 99.19%
PP121
PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , ...
HPK1-IN-2
T9017
HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hema...
DGY-06-116
T22306
DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.
Benidipine hydrochloride
T6227
Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.
squarunkinA
T9002
squarunkinA is a novel modulator of the UNC119-Cargo Interaction, potently and selectively inhibiting the binding of a myristoylated peptide representing the N-t...
UM-164
T4597
UM-164 (DAS-DFGO-II) is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164 also potently inhibits p38α and p38β.
A 419259 trihydrochloride
TQ0132
A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn).
KX1-004
T1812
KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.
Tirbanibulin Mesylate
T15675
Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
Lyn-IN-1
T11916
Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and Lyn
ZM 306416
T1754
ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).
PD173955
T3063
PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC...
RK-24466
T16760
RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.
PD-161570
T23127
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c...
NCGC00262650
T8995
NCGC00262650 is an inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity.
Agerafenib
T2070
Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.
ON123300
T6920
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).
PP58
T13824
PP58 is an inhibitor of PDGFR, FGFR and Src family.
1-NM-PP1
T2153
1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
BMS-536924
T6419
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for ...
PP121
T2415
PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , ...
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