T1667 |
Tandutinib
|
387867-13-2
|
|
|
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus...
|
T13156L |
TG 100572 Hydrochloride
|
867331-64-4
|
98%
|
|
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
|
T8544 |
Masitinib mesylate
|
1048007-93-7
|
98%
|
|
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα...
|
T75163 |
GW297361
|
388627-21-2
|
98%
|
|
GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 ...
|
T68455 |
AP23846
|
878654-51-4
|
98%
|
|
AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream a...
|
T3063 |
PD173955
|
260415-63-2
|
98%
|
|
PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC...
|
T6982 |
SGI-7079
|
1239875-86-5
|
98%
|
|
SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR...
|
T9723 |
GluR6 antagonist-1
|
323176-64-3
|
98%
|
|
GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.
|
T10531 |
BGB-102
|
807640-87-5
|
98%
|
|
BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular deg...
|
T13000 |
Src Inhibitor 3
|
2380027-49-4
|
98%
|
|
Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferati...
|
T17267 |
XL228
|
898280-07-4
|
98%
|
|
XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
|
T1811 |
WH-4-023
|
837422-57-8
|
98%
|
|
WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.
|
T13186 |
TL02-59
|
1315330-17-6
|
98%
|
|
TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-5...
|
T6028 |
PF 477736
|
952021-60-2
|
98%
|
|
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CS...
|
T14072 |
A-443654
|
552325-16-3
|
98%
|
|
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
T35384 |
TPX-0046
|
2359650-19-2
|
98%
|
|
TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.
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T63875 |
Bosutinib hydrate
|
918639-08-4
|
98%
|
|
Bosutinib hydrate (SKI-606 hydrate) is an orally active and potent dual kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of Philadelphia Chromo...
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T6057 |
URMC-099
|
1229582-33-5
|
98%
|
|
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
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T8499 |
ECF506
|
1914078-41-3
|
98%
|
|
eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)
|