TGF-beta/Smad

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.

Cat No.	Product Name
T12923	SIS3 free base	SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
T13137	TGFβRI-IN-1	TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respe...
T1748	Kartogenin	Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
T1763	SB525334HOT	SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
T2048	LY-364947	LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T2109	SD-208	SD-208, a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
T2123	LY2109761HOT	LY2109761 is a selective inhibitor of the TGF-β receptor I/II kinases (Ki: 38/300 nM).
T2273	ITD-1	ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
T2386	Pirfenidone	Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and t...
T2416	BIX02189	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
T2510	GalunisertibHOT	Galunisertib is an orally available antagonist of TβRI (IC50: 56 nM) with potential antineoplastic activity.
T2565	Hesperetin	Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges...
T2803	Monocrotaline	Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other...
T3025	Asiaticoside	Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and bur...
T3636	SIS3	SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signa...
T3674	Hydroxysafflor yellow A	Hydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term a...
T3924	Astragaloside II	Astragaloside II is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteo...
T4662	SJ000291942	SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ...
T5125	LY3200882	LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
T5197	BIBF0775	BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
T6324	BIX02188	BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2,...
T6337	RepSox	RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor.
T6S1373	Vitexicarpin	1. Vitexicarpin can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells. 2. Vitexicarpin may beco...
T7676	LSKL, Inhibitor of Thrombospondin TSP-1	LSKL, Inhibitor of Thrombospondin TSP-1(TSP-1) is activation of TGF-β .
T8330	BIO-013077-01	BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.
TN1040	Skullcapflavone II	Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skul...
TN1507	Clematichinenoside AR	Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associ...
TN2165	Rubrofusarin-6-O-beta-D-gentiobioside	Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that i...
TN3753	Dalbergioidin	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyce...
TQ0184	Chebulinic acid	Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.