T1748 |
Kartogenin |
Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. |
T1763 |
SB525334HOT |
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM). |
T2048 |
LY-364947 |
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I. |
T2109 |
SD-208 |
SD-208, a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII. |
T2123 |
LY2109761HOT |
LY2109761 is a selective inhibitor of the TGF-β receptor I/II kinases (Ki: 38/300 nM). |
T2273 |
ITD-1 |
ITD-1 is a potent and highly selective TGFβ pathway inhibitor. |
T2386 |
Pirfenidone |
Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and t...
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T2416 |
BIX02189 |
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM. |
T2510 |
GalunisertibHOT |
Galunisertib is an orally available antagonist of TβRI (IC50: 56 nM) with potential antineoplastic activity. |
T2565 |
Hesperetin |
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges...
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T2803 |
Monocrotaline |
Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other...
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T3025 |
Asiaticoside |
Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and bur...
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T3636 |
SIS3 |
SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signa...
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T3674 |
Hydroxysafflor yellow A |
Hydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term a...
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T3924 |
Astragaloside II |
Astragaloside II is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteo...
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T6324 |
BIX02188 |
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2,...
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T6337 |
RepSox |
RepSox is a potent and selective of the TGFβR-1/ALK5 inhibitor. |
T6S1373 |
Vitexicarpin |
1. Vitexicarpin can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells. 2. Vitexicarpin may beco...
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T4662 |
SJ000291942 |
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ...
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T5125 |
LY3200882 |
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). |
T5197 |
BIBF0775 |
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM). |
T7676 |
LSKL, Inhibitor of Thrombospondin TSP-1 |
LSKL, Inhibitor of Thrombospondin TSP-1(TSP-1) is activation of TGF-β . |
TQ0184 |
Chebulinic acid |
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. |
T8330 |
BIO-013077-01 |
BIO-013077-01 is a potent TGFbeta family type I receptors antagonist. |
TN1040 |
Skullcapflavone II |
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skul...
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TN1507 |
Clematichinenoside AR |
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associ...
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TN2165 |
Rubrofusarin-6-O-beta-D-gentiobioside |
Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that i...
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T12923 |
SIS3 free base |
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. |
T13137 |
TGFβRI-IN-1 |
TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respe...
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TN3753 |
Dalbergioidin |
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyce...
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