TGF-beta/Smad

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.

Cat. No.	Product name	CAS No.	Purity	Chemical Structure
T79603	3,7-DMF	20950-52-1	98%
T79603	3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation. By indu...
T79789	DT-6	2414315-95-8	98%
T79789	DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing p...
T80562	Nisevokitug	2649854-92-0	98%	Nisevokitug
T80562	Nisevokitug (NIS-793) is an IgG2λ human monoclonal antibody that targets TGF-β (TGFB1/TGFB2). It is produced in CHO-K1 cells [1].			Nisevokitug
T80628	Myristoyl tetrapeptide-12	959610-24-3	98%
T80628	Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].
T12923	(Rac)-SIS3 free base	1009104-85-1	98%
T12923	SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
TN3753	Dalbergioidin	30368-42-4	98%
TN3753	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
T13137	TGFβRI-IN-1	1950628-94-0	98%
T13137	TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively...
T3674	Hydroxysafflor yellow A	78281-02-4	99.99%
T3674	Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver fro...
T2386	Pirfenidone	53179-13-8	99.93%
T2386	Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, ...
TN2165	Rubrofusarin gentiobioside	24577-90-0	99.91%
TN2165	Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA bindi...
T2896	Alantolactone	546-43-0	99.91%
T2896	Alantolactone (Inula camphor)(Alant camphor), a sesquiterpene lactone, has potential activity against triple-negative breast Y MDA-MB-231 cells by suppressing th...
T2273	ITD-1	1099644-42-4	99.89%
T2273	ITD-1 is a potent and highly selective TGFβ pathway inhibitor.
T1726	SB-431542	301836-41-9	99.87%
T1726	SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other...
T2416	BIX02189	1094614-85-3	99.86%
T2416	BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
T1944	LDN-214117	1627503-67-6	99.85%
T1944	LDN-214117 is a potent and selective ALK2 inhibitor.
T2754	Oxymatrine	16837-52-8	99.84%
T2754	Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment a...
T4975	SM 16	614749-78-9	99.81%
T4975	SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
TN1040	Skullcapflavone II	55084-08-7	99.78%
TN1040	Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavon...
T35348	LDN-193189 2HCl	1435934-00-1	99.78%
T35348	LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM...
T16708	R-268712	879487-87-3	99.77%
T16708	R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...