TGF-beta/Smad

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.

Cat. No.	Product name	CAS No.	Purity
T10572L	BMT-124110 Formate	T10572L	99.17%
T10572L	BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase ...
T4283	SRI-011381	1629138-41-5	99.11%
T4283	SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
T1935	LDN193189	1062368-24-4	99.11%
T1935	LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for...
T4662	SJ000291942	425613-09-8	99.07%
T4662	SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
T8785	HALOFUGINONE LACTATE	82186-71-8	99.02%
T8785	HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone ...
T6146	Dorsomorphin dihydrochloride	1219168-18-9	98.89%
T6146	Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on s...
T6337	RepSox	446859-33-2	98.8%
T6337	RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). R...
T3031	A 83-01	909910-43-6	98.76%
T3031	A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse f...
T38752	EW-7195	1352609-28-9	98.76%
T38752	EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher tha...
T2462	SB-505124	694433-59-5	98.74%
T2462	SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.
T2565	Hesperetin	520-33-2	98.54%
T2565	Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges....
T3524	Halofuginone hydrobromide	64924-67-0	98.5%
T3524	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
TQ0184	Chebulinic acid	18942-26-2	98.4%
TQ0184	Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T1763	SB 525334	356559-20-1	98.39%
T1763	SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
T1943	ML347	1062368-49-3	98.3%
T1943	ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
T8730	BMS986260	2001559-19-7	98.22%
T8730	BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).
T3025	Asiaticoside	16830-15-2	98.07%
T3025	Asiaticoside (Emdecassol) (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wo...
T9523	TGFβRI-IN-3	2763602-67-9	98.02%
T9523	TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has poten...
T2109	SD-208	627536-09-8	98%
T2109	SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.
T1800	GW788388	452342-67-5	98%
T1800	GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.