T0457 |
Probenecid |
Probenecid is a benzoic acid derivative with antihyperuricemic property. |
T0647 |
Tryptamine |
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
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T0882 |
D-Camphor |
(+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties. |
T1062 |
Capsaicin |
Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open...
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T1321 |
Nonivamide |
Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound...
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T1814 |
ICILIN |
Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist. |
T2007 |
RQ00203078 |
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist. |
T2170 |
SKF-96365 hydrochloride |
SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cy...
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T2298 |
ML204 |
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. |
T2711 |
TCS 5861528 |
TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively. |
T2845 |
Imperatorin |
Imperatorin is a modulator of p38,ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo. |
T2994 |
Cardamonin |
Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a no...
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T3727 |
Methyl syringate |
Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K....
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T4028 |
ML329 |
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity. |
T6379 |
AMG-517 |
AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV...
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T6530 |
HC-030031 |
HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively. |
T6617 |
Optovin |
Optovin is a TRPA1 activator, which is reversibly photoactivated. |
T6660 |
SB705498 |
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis. |
T6848 |
GSK1016790A |
GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells. |
T6977 |
SB366791 |
SB-366791 is a new and selective cinnamide TRPV1 antagonist. |
T4385 |
PF-4840154 |
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and ...
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T3865 |
beta-Eudesmol |
β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, incl...
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T4699 |
Hexamethylene amiloride |
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 μM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.01...
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T4680 |
HC-067047 |
HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH . |
T5479 |
AMG-333 |
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine. |
T5640 |
GSK2193874 |
GSK2193874 was identified as a selective, orally active TRPV4 blocker. |
T5786 |
TETRAHYDROPIPERINE |
TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. |
T5698 |
TRPM8 antagonist 2 |
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. |
T5962 |
N-Ethyl-p-menthane-3-carboxamide |
N-Ethyl-p-menthane-3-carboxamide is an agonist of TRPM8( EC50 : 3.7 μM). |
T7205 |
A 967079 |
A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively...
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T7177 |
Capsazepine |
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of ...
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T7102 |
BCTC |
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively) |
T7189 |
AMG9810 |
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively...
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T7416 |
WS-12 |
WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM) |
T7572 |
RN-1734 |
RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, μmTRPV4 and rTRPV4,respectively) |
T7526 |
JNJ-17203212 |
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM). |
TQ0001 |
1,4-Cineole |
1,4-Cineole is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1. |
T7430 |
AM-0902 |
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1). |
TQ0157 |
EIPA |
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
T8307 |
Hydroxy-α-sanshool |
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 µM). |
T8410 |
ASP7663 |
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo. |
TN1583 |
Dihydromorin |
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal ...
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T14067 |
A-1165442 |
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM. |
T8425 |
Linoleoyl Ethanolamide |
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor ...
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T13546 |
AM12 |
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM). |
T10300 |
AMG2850 |
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8). |
T11394 |
GFB-8438 |
GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects m...
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T11172 |
EIPA hydrochloride |
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50...
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T13212 |
TRPA1 Antagonist 1 |
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50 of 8 nM), and is a methylene phosphate prodrug which converts to its active parent drug, . |
T15434 |
GSK2798745 |
GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure. GSK2798745 is a selective and orally active transi...
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T15439 |
GSK3395879 |
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50 of 1 nM for hTRPV4). |
T15628 |
JT010 |
JT010 is an effective agonist of TRPA1 (EC50: 0.65 nM). |
T15634 |
JYL 1421 |
JYL 1421 is an antagonist of TRPV1 receptor (IC50: 8 nM). |
T8528 |
AC1903 |
AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss. |
T16483 |
PF-05105679 |
PF-05105679 has the potential for cold-related pain. PF-05105679 is an orally active and selective TRPM8 antagonist (IC50: 103 nM). |
T16532 |
Pico145 |
Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits (−)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It ...
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T16763 |
RN-1747 |
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and r...
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T15758 |
Linopirdine |
Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine...
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T17006 |
TC-I 2014 |
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastati...
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T8562 |
A 425619 |
A 425619 is a potent TRPV1 antagonist |
T8565 |
N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride |
N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4. |
T8607 |
M-084 hydrochloride |
M-084 hydrochloride is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects. |
TN4469 |
(+)-Lyoniresinol |
Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activa...
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T16686 |
Pyr10 |
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal i...
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