TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.

Cat No.	product name
T0457	Probenecid	Probenecid is a benzoic acid derivative with antihyperuricemic property.
T0647	Tryptamine	Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
T0882	D-Camphor	(+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
T1062	Capsaicin	Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open...
T1321	Nonivamide	Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound...
T1814	ICILIN	Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
T2007	RQ00203078	RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
T2170	SKF-96365 hydrochloride	SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cy...
T2298	ML204	ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T2711	TCS 5861528	TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
T2845	Imperatorin	Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2994	Cardamonin	Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a no...
T3727	Methyl syringate	Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K....
T4028	ML329	ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
T6379	AMG517	AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV...
T6530	HC030031	HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
T6617	Optovin	Optovin is a TRPA1 activator, which is reversibly photoactivated.
T6660	SB705498	SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
T6848	GSK1016790A	GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.
T6977	SB366791	SB-366791 is a new and selective cinnamide TRPV1 antagonist.
T4385	PF4840154	PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and ...
T3865	beta-Eudesmol	β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, incl...
T4699	Hexamethylene amiloride	HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.01...
T4680	HC067047	HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
T5479	AMG-333	AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
T5640	GSK2193874	GSK2193874 was identified as a selective, orally active TRPV4 blocker.
T5786	TETRAHYDROPIPERINE	TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
T5698	TRPM8 antagonist 2	TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
T5962	N-Ethyl-p-menthane-3-carboxamide	N-Ethyl-p-menthane-3-carboxamide is an agonist of TRPM8( EC50 : 3.7 μM).
T7205	A 967079	A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively...
T7177	Capsazepine	Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of...
T7102	BCTC	BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
T7189	AMG9810	AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively...
T7416	WS-12	WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)
T7572	RN-1734	RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)
T7526	JNJ-17203212	JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
TQ0001	1,4-Cineole	1,4-Cineole is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
T7430	AM-0902	AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
TQ0157	EIPA	EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
T8307	Hydroxy-α-sanshool	Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 µM).
T8410	ASP7663	ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
TN1583	Dihydromorin	trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal ...
T14067	A-1165442	A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
T8425	Linoleoyl Ethanolamide	Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor ...
T13546	AM12	AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
T10300	AMG2850	AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
T11394	GFB-8438	GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
T11172	EIPA hydrochloride	EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50...
T13212	TRPA1 Antagonist 1	TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
T15434	GSK2798745	GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in...
T15439	GSK3395879	GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
T15628	JT010	JT010 is an effective agonist of TRPA1 (EC50: 0.65 nM).
T15634	JYL 1421	JYL 1421 is an antagonist of TRPV1 receptor (IC50: 8 nM).
T8528	AC1903	AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
T16483	PF-05105679	PF-05105679 has the potential for cold-related pain. PF-05105679 is an orally active and selective TRPM8 antagonist (IC50: 103 nM).
T16532	Pico145	Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits (−)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It ...
T16763	RN-1747	RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and r...
T15758	Linopirdine	Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine ...
T17006	TC-I 2014	TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastati...
T8562	A 425619	A 425619 is a potent TRPV1 antagonist
T8565	N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride	N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.
T8607	M-084 hydrochloride	M-084 hydrochloride is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.
TN4469	(+)-Lyoniresinol	Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activa...
T16686	Pyr10	Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal i...
T1109	Zucapsaicin	Zucapsaicin is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.Zucapsaicin is a synthetic cis isomer of natural capsaicin that...
T10537	BI-749327	BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).
T2952	Camphor	Camphor is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infe...
T2807	Caffeic Acid	Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activ...
T16688	Pyr6	Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entr...
T13214L	TRPV4 agonist-1 free base	TRPV4 agonist-1 free base is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
T8449	TC-I2000	TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
T8442	M8-B Hydrochloride	M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.
T8440	LASSBio-1135	LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
T4693	2-APB	2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at high...
T0399	Methyl salicylate	Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute...
T0399	Methyl salicylate	Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute...
TN1377	alpha-Spinasterol	α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects....