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Membrane transporter/Ion channel TRP/TRPV Channel

TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Cat No. product name
T0457 Probenecid Probenecid is a benzoic acid derivative with antihyperuricemic property.
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
T0882 D-Camphor (+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
T1062 Capsaicin Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open...
T1321 Nonivamide Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound...
T1814 ICILIN Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
T2007 RQ00203078 RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
T2170 SKF-96365 hydrochloride SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cy...
T2298 ML204 ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T2711 TCS 5861528 TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
T2845 Imperatorin Imperatorin is a modulator of p38,ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T2994 Cardamonin Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a no...
T3727 Methyl syringate Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K....
T4028 ML329 ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
T6379 AMG-517 AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV...
T6530 HC-030031 HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
T6617 Optovin Optovin is a TRPA1 activator, which is reversibly photoactivated.
T6660 SB705498 SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
T6848 GSK1016790A GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
T6977 SB366791 SB-366791 is a new and selective cinnamide TRPV1 antagonist.
T4385 PF-4840154 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and ...
T3865 beta-Eudesmol β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, incl...
T4699 Hexamethylene amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 μM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.01...
T4680 HC-067047 HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
T5479 AMG-333 AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
T5640 GSK2193874 GSK2193874 was identified as a selective, orally active TRPV4 blocker.
T5786 TETRAHYDROPIPERINE TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
T5698 TRPM8 antagonist 2 TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
T5962 N-Ethyl-p-menthane-3-carboxamide N-Ethyl-p-menthane-3-carboxamide is an agonist of TRPM8( EC50 : 3.7 μM).
T7205 A 967079 A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively...
T7177 Capsazepine Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of ...
T7102 BCTC BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
T7189 AMG9810 AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively...
T7416 WS-12 WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)
T7572 RN-1734 RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, μmTRPV4 and rTRPV4,respectively)
T7526 JNJ-17203212 JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
TQ0001 1,4-Cineole 1,4-Cineole is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
T7430 AM-0902 AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
TQ0157 EIPA EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
T8307 Hydroxy-α-sanshool Hydroxy-​α-​sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 µM).
T8410 ASP7663 ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo. 
TN1583 Dihydromorin trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal ...
T14067 A-1165442 A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
T8425 Linoleoyl Ethanolamide Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor ...
T13546 AM12 AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
T10300 AMG2850 AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
T11394 GFB-8438 GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects m...
T11172 EIPA hydrochloride EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50...
T13212 TRPA1 Antagonist 1 TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50 of 8 nM), and is a methylene phosphate prodrug which converts to its active parent drug, .
T15434 GSK2798745 GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure. GSK2798745 is a selective and orally active transi...
Probenecid
T0457CAS 57-66-9
Probenecid is a benzoic acid derivative with antihyperuricemic property.
Tryptamine
T0647CAS 61-54-1
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
D-Camphor
T0882CAS 464-49-3
(+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
Capsaicin
T1062CAS 404-86-4
Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open...
Nonivamide
T1321CAS 2444-46-4
Nonivamide is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Nonivamide is an organic compound...
ICILIN
T1814CAS 36945-98-9
Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
RQ00203078
T2007CAS 1254205-52-1
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
SKF-96365 hydrochloride
T2170CAS 130495-35-1
SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cy...
ML204
T2298CAS 5465-86-1
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
TCS 5861528
T2711CAS 332117-28-9
TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
Imperatorin
T2845CAS 482-44-0
Imperatorin is a modulator of p38,ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Cardamonin
T2994CAS 19309-14-9
Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a no...
Methyl syringate
T3727CAS 884-35-5
Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K....
ML329
T4028CAS 19992-50-8
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
AMG-517
T6379CAS 659730-32-2
AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV...
HC-030031
T6530CAS 349085-38-7
HC-030031 is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
Optovin
T6617CAS 348575-88-2
Optovin is a TRPA1 activator, which is reversibly photoactivated.
SB705498
T6660CAS 501951-42-4
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.
GSK1016790A
T6848CAS 942206-85-1
GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.
SB366791
T6977CAS 472981-92-3
SB-366791 is a new and selective cinnamide TRPV1 antagonist.
PF-4840154
T4385CAS 1332708-14-1
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and ...
beta-Eudesmol
T3865CAS 473-15-4
β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, incl...
Hexamethylene amiloride
T4699CAS 1428-95-1
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 μM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.01...
HC-067047
T4680CAS 883031-03-6
HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .
AMG-333
T5479CAS 1416799-28-4
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
GSK2193874
T5640CAS 1336960-13-4
GSK2193874 was identified as a selective, orally active TRPV4 blocker.
TETRAHYDROPIPERINE
T5786CAS 23434-88-0
TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
TRPM8 antagonist 2
T5698CAS 259674-19-6
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes.
N-Ethyl-p-menthane-3-carboxamide
T5962CAS 39711-79-0
N-Ethyl-p-menthane-3-carboxamide is an agonist of TRPM8( EC50 : 3.7 μM).
A 967079
T7205CAS 1170613-55-4
A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively...
Capsazepine
T7177CAS 138977-28-3
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of ...
BCTC
T7102CAS 393514-24-4
BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
AMG9810
T7189CAS 545395-94-6
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively...
WS-12
T7416CAS 68489-09-8
WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)
RN-1734
T7572CAS 946387-07-1
RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, μmTRPV4 and rTRPV4,respectively)
JNJ-17203212
T7526CAS 821768-06-3
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
1,4-Cineole
TQ0001CAS 470-67-7
1,4-Cineole is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
AM-0902
T7430CAS 1883711-97-4
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
EIPA
TQ0157CAS 1154-25-2
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
Hydroxy-α-sanshool
T8307CAS 83883-10-7
Hydroxy-​α-​sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 µM).
ASP7663
T8410CAS 1190217-35-6
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo. 
Dihydromorin
TN1583CAS 18422-83-8
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal ...
A-1165442
T14067CAS 1221443-94-2
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
Linoleoyl Ethanolamide
T8425CAS 68171-52-8
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor ...
AM12
T13546CAS 2387510-84-9
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
AMG2850
T10300CAS 1470018-52-0
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
GFB-8438
T11394CAS 2304549-73-1
GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects m...
EIPA hydrochloride
T11172CAS 1345839-28-2
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50...
TRPA1 Antagonist 1
T13212CAS 1984825-08-2
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50 of 8 nM), and is a methylene phosphate prodrug which converts to its active parent drug, .
GSK2798745
T15434CAS 1419609-94-1
GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure. GSK2798745 is a selective and orally active transi...