TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.

Cat. No.	Product name	CAS No.	Purity
TN1583	Dihydromorin	18422-83-8	98%
TN1583	trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
T11172	EIPA hydrochloride	1345839-28-2	98%
T11172	EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
T15439	GSK3395879	2215852-91-6	98%
T15439	GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
TN4469	(+)-Lyoniresinol	14464-90-5	98%
TN4469	Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activat...
T28118	MSP3	1820968-63-5	98%
T28118	MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.
T15434	GSK2798745	1419609-94-1	98%
T15434	GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
T17006	TC-I 2014	1221349-53-6	98%
T17006	TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin...
T13546	AM12	2387510-84-9	98%
T13546	AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
T14087	ABT-239	460746-46-7	98%
T14087	ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist. Its a transient receptor potential vanilloid type 1 (TRPV1) antagonist.
T14067	A-1165442	1221443-94-2	98%
T14067	A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
T13212	TRPA1 Antagonist 1	1984825-08-2	98%
T13212	TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
T13214	TRPV4 agonist-1	2314467-60-0	98%
T13214	TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
T37428	TRPC6-PAM-C20	667427-75-0	98%
T37428	TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 wi...
T24477	MK6-83	1062271-24-2	98%
T24477	MK6-83 is the transient receptor potential channel ML3 agonist.
T40042	Evifacotrep	2413739-88-3	98%
T40042	Evifacotrep is a short transient receptor potential channel 5 ( TRPC5 ) antagonist (WO2020061162, compound 100). Evifacotrep can be used for the research of neur...
T23106	Olvanil	58493-49-5	98%
T23106	Olvanil is a vanilloid receptor agonist with EC50 of 0.7nM.
T8562	A 425619	581809-67-8	98%
T8562	A 425619 is a potent TRPV1 antagonist
T21543	AP 18	55224-94-7	98%
T21543	AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human a...
T10300	AMG2850	1470018-52-0	98%
T10300	AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
T16763	RN-1747	1024448-59-6	98%
T16763	RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rTRPV...