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TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Cat No. product name
T9709 TRPM8 antagonist 3 TRPM8 antagonist 3 是 TRPM8 的阻断剂 (IC50 = 11 nM)。
T9818 NGD-8243 NGD-8243 是一种 TRPV1 抑制剂,可用于预防和治疗心脏肥大的研究。
T33429 MK-2295 MK-2295 是一种有效的 TRPV1 拮抗剂。 MK-2295 可用于治疗慢性疼痛的研究。
T12514 Podocarpic acid Podocarpic acid 是一种天然产物,是一种新型 TRPA1 激活剂。
T23004 ML-SA1 ML-SA1 is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 v...
T21165 Pellitorine Pellitorine is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.
T6S1684 8-Gingerol 1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Ging...
T8307 Hydroxy-α-sanshool Hydroxy- α- sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
T1622 Rosiglitazone maleate Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
T0175L Amiloride hydrochloride dihydrate Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negati...
TN1377 α-Spinasterol α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α...
T0334 Rosiglitazone Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare...
T2994 (E)-Cardamonin Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a nov...
T19723 AMTB hydrochloride AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder mictu...
T7177 Capsazepine Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of c...
T2539 Fingolimod hydrochloride Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T2845 Imperatorin Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T13214 TRPV4 agonist-1 TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
T7191 Diphenyleneiodonium chloride Diphenyleneiodonium chloride(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 µM, respectively),and displays broad-spectrum bacte...
T22360 MDR-652 MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRP...
T4699 5-(N,N-Hexamethylene)-amiloride HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-...
T5454 N-(p-amylcinnamoyl) Anthranilic Acid N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
T2170 SKF-96365 hydrochloride SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cyt...
T9776 TRPM4 inhibitor 8 TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
T28020 Mesendogen Mesendogen is an inhibitor of TRPM6. Mesendogen alters magnesium homeostasis, promotes mesoderm and definitive endoderm differentiation.
T0851 Pregnenolone Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T1407 (-)-Menthol L-Menthol is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic proper...
T23322 SB 452533 TRPV1 antagonist
T22537 9-Phenanthrol TRPM4 blocker
T0175 Amiloride hydrochloride Amiloride hydrochloride is an effective sodium channel blocker of epithelial.
T1062 Capsaicin Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open ...
T1109 (Z)-Capsaicin Zucapsaicin is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.Zucapsaicin is a synthetic cis isomer of natural capsaicin that ...
T12941 SN 2 SN 2 is a novel and potent TRPML3 ion channel activator(EC50 of 1.8±0.13 μM).
T0399 Methyl salicylate Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute ...
T6848 GSK1016790A GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.
T6646 Rosiglitazone hydrochloride Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T0457 Probenecid Probenecid is a benzoic acid derivative with antihyperuricemic property.
TCS0102 Pulegone 1. Pulegone has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a ...
T24477 MK6-83 MK6-83 is the transient receptor potential channel ML3 agonist.
T2952 Camphor Camphor is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infec...
T12306 OMDM-5 OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
T0882 (+)-Camphor (+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
T23107 Ononetin TRPM3 channel blocker
T2163 Dihydrocapsaicin Dihydrocapsaicin is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum...
T001-00000003 PF-04745637 PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].
T2711 Chembridge-5861528 TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
T2807 Caffeic Acid Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
T2298 ML204 ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T1814 ICILIN Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
TRPM8 antagonist 3
T9709
TRPM8 antagonist 3 是 TRPM8 的阻断剂 (IC50 = 11 nM)。
NGD-8243
T9818
NGD-8243 是一种 TRPV1 抑制剂,可用于预防和治疗心脏肥大的研究。
MK-2295
T33429
MK-2295 是一种有效的 TRPV1 拮抗剂。 MK-2295 可用于治疗慢性疼痛的研究。
Podocarpic acid
T12514
Podocarpic acid 是一种天然产物,是一种新型 TRPA1 激活剂。
ML-SA1
T23004
ML-SA1 is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 v...
Pellitorine
T21165
Pellitorine is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.
8-Gingerol
T6S1684
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Ging...
Hydroxy-α-sanshool
T8307
Hydroxy- α- sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
Tryptamine
T0647
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
Rosiglitazone maleate
T1622
Rosiglitazone Maleate is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity...
Amiloride hydrochloride dihydrate
T0175L
Amiloride hydrochloride is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negati...
α-Spinasterol
TN1377
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. ...
Rosiglitazone
T0334
Rosiglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Rosiglitazone has been linked to rare...
(E)-Cardamonin
T2994
Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It is a nov...
AMTB hydrochloride
T19723
AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder mictu...
Capsazepine
T7177
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of c...
Fingolimod hydrochloride
T2539
Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
Imperatorin
T2845
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
TRPV4 agonist-1
T13214
TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
Diphenyleneiodonium chloride
T7191
Diphenyleneiodonium chloride(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 µM, respectively),and displays broad-spectrum bact...
MDR-652
T22360
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRP...
5-(N,N-Hexamethylene)-amiloride
T4699
HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 µM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013...
N-(p-amylcinnamoyl) Anthranilic Acid
T5454
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
SKF-96365 hydrochloride
T2170
SKF-96365, a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induce cyt...
TRPM4 inhibitor 8
T9776
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
Mesendogen
T28020
Mesendogen is an inhibitor of TRPM6. Mesendogen alters magnesium homeostasis, promotes mesoderm and definitive endoderm differentiation.
Pregnenolone
T0851
Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
(-)-Menthol
T1407
L-Menthol is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic proper...
SB 452533
T23322
TRPV1 antagonist
9-Phenanthrol
T22537
TRPM4 blocker
Amiloride hydrochloride
T0175
Amiloride hydrochloride is an effective sodium channel blocker of epithelial.
Capsaicin
T1062
Capsaicin is an active component of chili peppers. It selectively binds to TRPV1 which is a heat-activated calcium channel. Capsaicin causes the channel to open ...
(Z)-Capsaicin
T1109
Zucapsaicin is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.Zucapsaicin is a synthetic cis isomer of natural capsaicin that ...
SN 2
T12941
SN 2 is a novel and potent TRPML3 ion channel activator(EC50 of 1.8±0.13 μM).
Methyl salicylate
T0399
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute ...
GSK1016790A
T6848
GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.
Rosiglitazone hydrochloride
T6646
Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
Probenecid
T0457
Probenecid is a benzoic acid derivative with antihyperuricemic property.
Pulegone
TCS0102
1. Pulegone has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a ...
MK6-83
T24477
MK6-83 is the transient receptor potential channel ML3 agonist.
Camphor
T2952
Camphor is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infec...
OMDM-5
T12306
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
(+)-Camphor
T0882
(+)-Camphor is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
Ononetin
T23107
TRPM3 channel blocker
Dihydrocapsaicin
T2163
Dihydrocapsaicin is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum...
PF-04745637
T001-00000003
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].
Chembridge-5861528
T2711
TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
Caffeic Acid
T2807
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
ML204
T2298
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
ICILIN
T1814
Icilin(AG 3-5) is a synthetic TRPM8 ion channel super-agonist.
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