T70540 |
Pinokalant
|
149759-26-2
|
99.09%
|
|
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves ...
|
T5479 |
AMG 333
|
1416799-28-4
|
99.08%
|
|
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
|
T4028 |
ML329
|
19992-50-8
|
99.07%
|
|
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
|
T1407 |
(-)-Menthol
|
2216-51-5
|
99.01%
|
|
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local a...
|
T28020 |
Mesendogen
|
864716-85-8
|
98.90%
|
|
Mesendogen is an inhibitor of TRPM6. Mesendogen alters magnesium homeostasis, promotes mesoderm and definitive endoderm differentiation.
|
T8449 |
TC-I2000
|
1159996-20-9
|
98.87%
|
|
TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
|
T0882 |
(+)-Camphor
|
464-49-3
|
98.82%
|
|
(+)-Camphor (D-Camphor) is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
|
T9247 |
Vanilloid receptor antagonist 1
|
871814-52-7
|
98.77%
|
|
Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.
|
T72662 |
NMDAR/TRPM4-IN-2
|
2243506-33-2
|
98.77%
|
|
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
|
T9245 |
TRPM4-IN-1
|
351424-20-9
|
98.75%
|
|
TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.
|
T17006 |
TC-I 2014
|
1221349-53-6
|
98.75%
|
|
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin...
|
TCS0102 |
Pulegone
|
89-82-7
|
98.74%
|
|
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pule...
|
T22537 |
9-Phenanthrol
|
484-17-3
|
98.72%
|
|
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.
|
T16532 |
Pico145
|
1628287-16-0
|
98.71%
|
|
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cell...
|
T8307 |
Hydroxy-α-sanshool
|
83883-10-7
|
98.59%
|
|
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
|
T23322 |
SB 452533
|
459429-39-1
|
98.52%
|
|
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
|
T15628 |
JT010
|
917562-33-5
|
98.5%
|
|
JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).
|
T41233 |
Cis-22a
|
1819366-84-1
|
98.49%
|
|
Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative ...
|
T4385 |
PF-4840154
|
1332708-14-1
|
98.48%
|
|
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 2...
|
T37097 |
SET 2
|
2313525-20-9
|
98.43%
|
|
SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.
|