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TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T70540 Pinokalant 149759-26-2 99.09%
Pinokalant
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves ...
T5479 AMG 333 1416799-28-4 99.08%
AMG 333
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
T4028 ML329 19992-50-8 99.07%
ML329
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
T1407 (-)-Menthol 2216-51-5 99.01%
(-)-Menthol
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local a...
T28020 Mesendogen 864716-85-8 98.90%
Mesendogen
Mesendogen is an inhibitor of TRPM6. Mesendogen alters magnesium homeostasis, promotes mesoderm and definitive endoderm differentiation.
T8449 TC-I2000 1159996-20-9 98.87%
TC-I2000
TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
T0882 (+)-Camphor 464-49-3 98.82%
(+)-Camphor
(+)-Camphor (D-Camphor) is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
T9247 Vanilloid receptor antagonist 1 871814-52-7 98.77%
Vanilloid receptor antagonist 1
Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.
T72662 NMDAR/TRPM4-IN-2 2243506-33-2 98.77%
NMDAR/TRPM4-IN-2
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
T9245 TRPM4-IN-1 351424-20-9 98.75%
TRPM4-IN-1
TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.
T17006 TC-I 2014 1221349-53-6 98.75%
TC-I 2014
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin...
TCS0102 Pulegone 89-82-7 98.74%
Pulegone
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pule...
T22537 9-Phenanthrol 484-17-3 98.72%
9-Phenanthrol
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.
T16532 Pico145 1628287-16-0 98.71%
Pico145
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cell...
T8307 Hydroxy-α-sanshool 83883-10-7 98.59%
Hydroxy-α-sanshool
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
T23322 SB 452533 459429-39-1 98.52%
SB 452533
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
T15628 JT010 917562-33-5 98.5%
JT010
JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).
T41233 Cis-22a 1819366-84-1 98.49%
Cis-22a
Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative ...
T4385 PF-4840154 1332708-14-1 98.48%
PF-4840154
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 2...
T37097 SET 2 2313525-20-9 98.43%
SET 2
SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.
Pinokalant
T70540
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves ...
AMG 333
T5479
AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.
ML329
T4028
ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
(-)-Menthol
T1407
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local a...
Mesendogen
T28020
Mesendogen is an inhibitor of TRPM6. Mesendogen alters magnesium homeostasis, promotes mesoderm and definitive endoderm differentiation.
TC-I2000
T8449
TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
(+)-Camphor
T0882
(+)-Camphor (D-Camphor) is the oil extracted from the wood of the Camphor tree Cinnamomum Camphora with anti-inflammatory and analgesic properties.
Vanilloid receptor antagonist 1
T9247
Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.
NMDAR/TRPM4-IN-2
T72662
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
TRPM4-IN-1
T9245
TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.
TC-I 2014
T17006
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin...
Pulegone
TCS0102
1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pule...
9-Phenanthrol
T22537
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.
Pico145
T16532
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cell...
Hydroxy-α-sanshool
T8307
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
SB 452533
T23322
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).
JT010
T15628
JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).
Cis-22a
T41233
Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative ...
PF-4840154
T4385
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 2...
SET 2
T37097
SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.
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TargetMol