T64337 |
PF-04745637
|
1917294-46-2
|
97.91%
|
|
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].
|
T1814 |
ICILIN
|
36945-98-9
|
97.61%
|
|
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
|
T1321 |
Nonivamide
|
2444-46-4
|
97.61%
|
|
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Noni...
|
TQ0001 |
1,4-Cineole
|
470-67-7
|
97.15%
|
|
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
|
T15465 |
HC-070
|
1628291-95-1
|
97.06%
|
|
HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).
|
T9776 |
TRPM4 inhibitor 8
|
1353979-43-7
|
97%
|
|
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
|
T6848 |
GSK1016790A
|
942206-85-1
|
96.25%
|
|
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial ce...
|
TN2429 |
Capsiate
|
205687-01-0
|
96.24%
|
|
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
|
T3865 |
Beta-Eudesmol
|
473-15-4
|
95.62%
|
|
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a varie...
|
T23106 |
Olvanil
|
58493-49-5
|
95.06%
|
|
Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.
|
T22124 |
Oleoyl Serotonin
|
1002100-44-8
|
100.00%
|
|
Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.
|
T2711 |
Chembridge-5861528
|
332117-28-9
|
100%
|
|
Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respecti...
|
T14087 |
ABT-239
|
460746-46-7
|
100%
|
|
ABT-239 is a novel, highly efficacious antagonist belonging to the non-imidazole class of histamine H3 receptor (H3R) antagonists. It also acts as a transient re...
|
T0851 |
Pregnenolone
|
145-13-1
|
100%
|
|
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
|
T34081 |
Piromelatine
|
946846-83-9
|
100%
|
|
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibito...
|
T15543 |
IA-Alkyne
|
930800-38-7
|
|
|
IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactiv...
|
T8425 |
Linoleoyl Ethanolamide
|
68171-52-8
|
|
|
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in...
|
TN6791 |
Palvanil
|
69693-13-6
|
|
|
Palvanil (Hexadecanamide) is a fast desensitizing agonist of TRPV1. it may be promising agents in the therapy of IBS since it modulates intestinal motility and r...
|
T7430 |
AM-0902
|
1883711-97-4
|
|
|
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
|
T13214L |
TRPV4 agonist-1 free base
|
2314467-59-7
|
|
|
TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
|