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TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T64337 PF-04745637 1917294-46-2 97.91%
PF-04745637
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].
T1814 ICILIN 36945-98-9 97.61%
ICILIN
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
T1321 Nonivamide 2444-46-4 97.61%
Nonivamide
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Noni...
TQ0001 1,4-Cineole 470-67-7 97.15%
1,4-Cineole
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
T15465 HC-070 1628291-95-1 97.06%
HC-070
HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).
T9776 TRPM4 inhibitor 8 1353979-43-7 97%
TRPM4 inhibitor 8
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
T6848 GSK1016790A 942206-85-1 96.25%
GSK1016790A
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial ce...
TN2429 Capsiate 205687-01-0 96.24%
Capsiate
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
T3865 Beta-Eudesmol 473-15-4 95.62%
beta-Eudesmol
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a varie...
T23106 Olvanil 58493-49-5 95.06%
Olvanil
Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.
T22124 Oleoyl Serotonin 1002100-44-8 100.00%
Oleoyl Serotonin
Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.
T2711 Chembridge-5861528 332117-28-9 100%
Chembridge-5861528
Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respecti...
T14087 ABT-239 460746-46-7 100%
ABT-239
ABT-239 is a novel, highly efficacious antagonist belonging to the non-imidazole class of histamine H3 receptor (H3R) antagonists. It also acts as a transient re...
T0851 Pregnenolone 145-13-1 100%
Pregnenolone
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
T34081 Piromelatine 946846-83-9 100%
Piromelatine
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibito...
T15543 IA-Alkyne 930800-38-7
IA-Alkyne
IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactiv...
T8425 Linoleoyl Ethanolamide 68171-52-8
Linoleoyl Ethanolamide
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in...
TN6791 Palvanil 69693-13-6
Palvanil
Palvanil (Hexadecanamide) is a fast desensitizing agonist of TRPV1. it may be promising agents in the therapy of IBS since it modulates intestinal motility and r...
T7430 AM-0902 1883711-97-4
AM-0902
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
T13214L TRPV4 agonist-1 free base 2314467-59-7
TRPV4 agonist-1 free base
TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
PF-04745637
T64337
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].
ICILIN
T1814
ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
Nonivamide
T1321
Nonivamide (Nonanoic acid vanillylamide) is found in herbs and spices. Nonivamide is an alkaloid from Capsicum species Nonivamide is a flavoring ingredient. Noni...
1,4-Cineole
TQ0001
1,4-Cineole (Isocineole) is a natural, oxygenated monoterpene. 1,4-Cineole can activate both human TRPM8 and human TRPA1.
HC-070
T15465
HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).
TRPM4 inhibitor 8
T9776
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
GSK1016790A
T6848
GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial ce...
Capsiate
TN2429
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
beta-Eudesmol
T3865
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a varie...
Olvanil
T23106
Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.
Oleoyl Serotonin
T22124
Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.
Chembridge-5861528
T2711
Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respecti...
ABT-239
T14087
ABT-239 is a novel, highly efficacious antagonist belonging to the non-imidazole class of histamine H3 receptor (H3R) antagonists. It also acts as a transient re...
Pregnenolone
T0851
Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
Piromelatine
T34081
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibito...
IA-Alkyne
T15543
IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactiv...
Linoleoyl Ethanolamide
T8425
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in...
Palvanil
TN6791
Palvanil (Hexadecanamide) is a fast desensitizing agonist of TRPV1. it may be promising agents in the therapy of IBS since it modulates intestinal motility and r...
AM-0902
T7430
AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).
TRPV4 agonist-1 free base
T13214L
TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
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TargetMol