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Endocrinology/Hormones Thyroid hormone receptor(THR)

Thyroid hormone receptor(THR)

The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone.TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation. These receptors also have non-genomic effects that lead to second messenger activation, and corresponding cellular response.
Cat No. product name
T0840 Methimazole Methimazole is a thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl res...
T0864 L-Thyroxine Levothyroxine is the major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling ...
T0952 Carbimazole Carbimazole is an imidazole antithyroid agent. It is only found in individuals that have used or taken this drug. Carbimazole is metabolized to methimazole, whi...
T1309 Propylthiouracil Propylthiouracil is a thiourea derivative with an antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction w...
T1310 Deracil Deracil is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
T1604 Tiratricol Tiratricol is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials ...
T1653 Lyothyronine Liothyronine is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
T1669 Liothyronine sodium Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyro...
T3595 MGL3196 MGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist.
T5313 Sobetirome Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
T5360 Eprotirome Eprotirome, a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
T7578 reverse T3 reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
T15644 KAT681 KAT681 is a liver selective thyromimetic.
T15699 L-Thyroxine sodium salt pentahydrate DIO enzymes convert biologically active thyroid hormone from L-Thyroxine (T4). L-Thyroxine sodium salt pentahydrate is a synthetic hormone in the treatment of h...
T10855 CO23 CO23 is a selective agonist of the thyroid hormone receptor (TR) α and can be transported through the blood-brain barrier. CO23 is used for growth and developm...
T13072 Taltirelin acetate Taltirelin acetate is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic...
Methimazole
T0840CAS 60-56-0
Methimazole is a thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl res...
L-Thyroxine
T0864CAS 51-48-9
Levothyroxine is the major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling ...
Carbimazole
T0952CAS 22232-54-8
Carbimazole is an imidazole antithyroid agent. It is only found in individuals that have used or taken this drug. Carbimazole is metabolized to methimazole, whi...
Propylthiouracil
T1309CAS 51-52-5
Propylthiouracil is a thiourea derivative with an antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction w...
Deracil
T1310CAS 141-90-2
Deracil is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
Tiratricol
T1604CAS 51-24-1
Tiratricol is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials ...
Lyothyronine
T1653CAS 6893-02-3
Liothyronine is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
Liothyronine sodium
T1669CAS 55-06-1
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyro...
MGL3196
T3595CAS 920509-32-6
MGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist.
Sobetirome
T5313CAS 211110-63-3
Sobetirome is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
Eprotirome
T5360CAS 355129-15-6
Eprotirome, a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
reverse T3
T7578CAS 5817-39-0
reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
KAT681
T15644CAS 373641-87-3
KAT681 is a liver selective thyromimetic.
L-Thyroxine sodium salt pentahydrate
T15699CAS 6106-07-6
DIO enzymes convert biologically active thyroid hormone from L-Thyroxine (T4). L-Thyroxine sodium salt pentahydrate is a synthetic hormone in the treatment of h...
CO23
T10855CAS 1370363-74-8
CO23 is a selective agonist of the thyroid hormone receptor (TR) α and can be transported through the blood-brain barrier. CO23 is used for growth and developm...
Taltirelin acetate
T13072CAS 1549593-23-8
Taltirelin acetate is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic...
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