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Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4952 9-Hydroxycamptothecin 67656-30-8 99.79%
9-Hydroxycamptothecin
9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.
T13231 Trovafloxacin 147059-72-1 99.27%
Trovafloxacin
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
T14545 Berberine chloride hydrate 68030-18-2 98.94%
Berberine chloride hydrate
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic.Berberine chloride hydrate has antitumor activity, ...
TN2105 Proscillaridin A 466-06-8 98.38%
Proscillaridin A
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
T6724 Voreloxin 175414-77-4 98%
Voreloxin
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
T11090L Aldoxorubicin 1361644-26-9 98%
Aldoxorubicin
Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
T16726 Rebeccamycin 93908-02-2 98%
Rebeccamycin
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
T77873 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride 98%
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC) activit...
T77889 NH2-methylpropanamide-Exatecan TFA 1817857-35-4 98%
NH2-methylpropanamide-Exatecan TFA
Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.9...
T77901 Ac-Exatecan 2922852-48-8 98%
Ac-Exatecan
Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug conjugate (ADC) formulations (ADC Cytotoxin) and a...
T78630 Exatecan mesylate dihydrate 197720-53-9 98%
Exatecan mesylate dihydrate
Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].
T78717 Topoisomerase inhibitor 2 2713986-17-3 98%
Topoisomerase inhibitor 2
Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].
T78747 DiPT-4 98%
DiPT-4
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to cir...
T79263 Antitumor agent-102 98%
Antitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targets colorectal...
T79506 Topoisomerase II inhibitor 15 451516-79-3 98%
Topoisomerase II inhibitor 15
Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1].
T79539 Topoisomerase II inhibitor 16 2403729-27-9 98%
Topoisomerase II inhibitor 16
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the abi...
T79883 9-Chloromethyl-10-hydroxy-11-F-Camptothecin 2414594-22-0 98%
9-Chloromethyl-10-hydroxy-11-F-Camptothecin
9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential application...
T80967 Topoisomerase I inhibitor 9 1228150-86-4 98%
Topoisomerase I inhibitor 9
Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value o...
T80968 Topoisomerase I inhibitor 10 98%
Topoisomerase I inhibitor 10
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity. Specifically, it demonstrat...
T82934 AuM1Phe 98%
AuM1Phe
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization. It also impedes the proliferation ...
9-Hydroxycamptothecin
T4952
9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.
Trovafloxacin
T13231
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
Berberine chloride hydrate
T14545
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid commonly used as an antibiotic.Berberine chloride hydrate has antitumor activity, ...
Proscillaridin A
TN2105
Proscillaridin A is a natural product.It is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
Voreloxin
T6724
Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.
Aldoxorubicin
T11090L
Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubi...
Rebeccamycin
T16726
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase...
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
T77873
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC) activit...
NH2-methylpropanamide-Exatecan TFA
T77889
Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.9...
Ac-Exatecan
T77901
Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug conjugate (ADC) formulations (ADC Cytotoxin) and a...
Exatecan mesylate dihydrate
T78630
Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].
Topoisomerase inhibitor 2
T78717
Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].
DiPT-4
T78747
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to cir...
Antitumor agent-102
T79263
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targets colorectal...
Topoisomerase II inhibitor 15
T79506
Topoisomerase II inhibitor 15 (compound 2g) serves as a potent apoptotic inducer, exhibiting heightened selectivity for head and neck tumors [1].
Topoisomerase II inhibitor 16
T79539
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the abi...
9-Chloromethyl-10-hydroxy-11-F-Camptothecin
T79883
9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential application...
Topoisomerase I inhibitor 9
T80967
Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value o...
Topoisomerase I inhibitor 10
T80968
Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity. Specifically, it demonstrat...
AuM1Phe
T82934
AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization. It also impedes the proliferation ...
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