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Search Results for " tyrosine-kinases "

Targets

111

Compounds

7

Natural Products

233

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T6052 GW 441756 Apoptosis , Raf , Trk receptor , CDK
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
T7123 AMG-47a VEGFR , p38 MAPK , JAK , Src
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei...
T5168 EGFR-IN-12 EGFR Inhibitor Apoptosis , EGFR
EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.
T4185 Lavendustin C HDBA,NSC 666251 CaMK , EGFR , Tyrosinase , Src
lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
T17184 Tyrosine kinase inhibitor c-Met/HGFR , Tyrosine Kinases
Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.
T0093L Sorafenib Bay 43-9006 Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T6351 MGCD-265 analog MGCD-265,Glesatinib Apoptosis , VEGFR , c-Met/HGFR
MGCD-265 analog (Glesatinib) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively.
T41003 KG5 Raf , FLT , PDGFR , c-Kit
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.
T0093 Sorafenib tosylate Bay 43-9006 Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T23127 PD-161570 PD 161570 EGFR , FGFR , PDGFR , Src
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a...
T7186 CZC-8004 CZC-00008004 Bcr-Abl
CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.
T13238 Tyrphostin AG1433 SU1433,AG1433 VEGFR , PDGFR
Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).
T9659 LCB 03-0110 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol Discoidin Domain Receptor (DDR)
LCB 03-0110 (3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol) is a potent inhibitor of discoidin domain receptor family tyrosine kinases and strongly inhibits several tyrosine kinases, including th...
T60220 ROS kinases-IN-1 ROS Kinase
ROS kinases-IN-1 is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity.
T7101 Tyrphostin AG30 Tyrphostin AG30(AG30) EGFR , Tyrosine Kinases
Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.
T7435 Selitrectinib LOXO-195 Trk receptor
Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK)( TrkA and TrkC with IC50s of 0.6 and <2.5 nM, respectively)
T5407 Branebrutinib BMS986195 BTK
Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK).
T3463 NVP-ACC789 ACC-789,ZK202650 VEGFR , PDGFR
ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.
T50088 N-phenylthiophene-2-carboximidamide Others
N-phenylthiophene-2-carboximidamide is a thiophene derivative that functions as an inhibitor of protein tyrosine kinases (PTKs) and a ligand for G protein-coupled receptors (GPCRs).
T2045 JANEX-1 Jak3 inhibitor I,WHI-P131 JAK
JANEX-1 (Jak3 inhibitor I) is a cell-permeable, reversible, effective, ATP-competitive, and selective inhibitor of JAK3 (IC50: 78 μM); little inhibitory against JAK1/2, or Zap/Syk or SRC tyrosine kinases.
T6217 LFM-A13 PLK , JAK , BTK
LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.
T6517 Golvatinib E-7050 VEGFR , c-Met/HGFR
Golvatinib (E-7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic ...
T8976 PD-089828 EGFR , FGFR , PDGFR , Src
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ...
T5164 Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
T2677 Crenolanib ARO 002,CP-868596 FLT , PDGFR , Autophagy
Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).
T10870L CP-547632 VEGFR , FGFR , PDGFR , BTK
CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective, with higher selectivity for VEGFR2 and bFGF than...
T6095 JNJ-38877605 c-Met/HGFR
JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.
T3980 Su1498 Tyrphostin SU 1498,AG 1498 VEGFR
Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,...
T2483 Dacomitinib PF-299804,PF-00299804,PF299 Apoptosis , EGFR
Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respective...
T3061 Lorlatinib PF-6463922,PF-06463922,Loratinib Apoptosis , Tyrosine Kinases , ROS , ALK , ROS Kinase
Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.
T63875 Bosutinib hydrate PF-5208763 hydrate,PF-05208763 hydrate,SKI-606 hydrate Bcr-Abl , Src
Bosutinib hydrate (SKI-606 hydrate) is an orally active and potent dual kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of Philadelphia Chromosome Positive Chronic Granulocytic Leukemia.
TQ0271 Falnidamol BIBX 1382 EGFR
Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine k...
T3211 Midostaurin N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251 Others , PKC
PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel...
T1661 Crizotinib PF-02341066 c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
T22349 JNJ-38158471 CS-2660 VEGFR , c-RET , c-Kit
JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM.
T6104 Cerdulatinib hydrochloride Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride MLK , c-Fms , Tyrosine Kinases , Hippo pathway , JAK , Syk
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19...
T1448L Dasatinib monohydrate BMS-354825 Monohydrate Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit...
T3080 Pyridone 6 Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I Tyrosine Kinases , JAK
Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...
T8402 Regorafenib Hydrochloride BAY73-4506 hydrochloride Raf , VEGFR , c-RET , PDGFR , Autophagy
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
T3570 SU4312 SU 4312,NSC 86429 VEGFR , PDGFR
SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 (SU 4312) unexpectedly protects against MPP(+) -induced neurotox...
T2349 BMS-754807 Trk receptor , c-Met/HGFR , IGF-1R
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity.
T21593 AAL-993 VEGFR
AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni...
T6594 MNS Syk , Src , p97
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
T21723L Epidermal Growth Factor Receptor Peptide Acetate Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base) Others
Epidermal Growth Factor Receptor Peptide Acetate (Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base)) exists on the cell surface and is activated by the binding of its specific ligands.EGFR belongs t...
T3691 (Rac)-SAR131675 SAR131675 VEGFR
(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is h...
T0097L Pazopanib GW786034 VEGFR , FGFR , PDGFR , c-Kit , Autophagy
Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1, -2 and -3, c-kit and PDGF-R, which may result i...
T68405 KW-2450 free base IGF-1R
KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.KW-2450 free base shows modest growth inhibitory activity and inhibits IGF-1-induced signaling in a mouse HT-29/GFP colo...
T4209 TAK-659 hydrochloride TAK-659 VEGFR , FLT , Tyrosine Kinases , JAK , Syk
TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.
T32613 LCB 03-0110 dihydrochloride Src
LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and T...
T19965 Dacomitinib hydrate PF 299804,PF00299804,PF 00299804,PF-00299804,PF299804,PF-299804 EGFR
Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds...

Compounds

GW 441756
T6052
Synonym:
Target: Apoptosis, Raf, Trk receptor, CDK
AMG-47a
T7123
Synonym:
Target: VEGFR, p38 MAPK, JAK, Src
EGFR-IN-12
T5168
Synonym: EGFR Inhibitor
Target: Apoptosis, EGFR
lavendustin C
T4185
Synonym: HDBA,NSC 666251
Target: CaMK, EGFR, Tyrosinase, Src
Tyrosine kinase inhibitor
T17184
Synonym:
Target: c-Met/HGFR, Tyrosine Kinases
Sorafenib
T0093L
Synonym: Bay 43-9006
Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy
MGCD-265 analog
T6351
Synonym: MGCD-265,Glesatinib
Target: Apoptosis, VEGFR, c-Met/HGFR
KG5
T41003
Synonym:
Target: Raf, FLT, PDGFR, c-Kit
Sorafenib tosylate
T0093
Synonym: Bay 43-9006
Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy
PD-161570
T23127
Synonym: PD 161570
Target: EGFR, FGFR, PDGFR, Src
CZC-8004
T7186
Synonym: CZC-00008004
Target: Bcr-Abl
Tyrphostin AG1433
T13238
Synonym: SU1433,AG1433
Target: VEGFR, PDGFR
LCB 03-0110
T9659
Synonym: 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol
Target: Discoidin Domain Receptor (DDR)
ROS kinases-IN-1
T60220
Synonym:
Target: ROS Kinase
Tyrphostin AG30
T7101
Synonym: Tyrphostin AG30(AG30)
Target: EGFR, Tyrosine Kinases
Selitrectinib
T7435
Synonym: LOXO-195
Target: Trk receptor
Branebrutinib
T5407
Synonym: BMS986195
Target: BTK
NVP-ACC789
T3463
Synonym: ACC-789,ZK202650
Target: VEGFR, PDGFR
N-phenylthiophene-2-carboximidamide
T50088
Synonym:
Target: Others
JANEX-1
T2045
Synonym: Jak3 inhibitor I,WHI-P131
Target: JAK
LFM-A13
T6217
Synonym:
Target: PLK, JAK, BTK
Golvatinib
T6517
Synonym: E-7050
Target: VEGFR, c-Met/HGFR
PD-089828
T8976
Synonym:
Target: EGFR, FGFR, PDGFR, Src
Cabozantinib hydrochloride
T5164
Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351
Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR
Crenolanib
T2677
Synonym: ARO 002,CP-868596
Target: FLT, PDGFR, Autophagy
CP-547632
T10870L
Synonym:
Target: VEGFR, FGFR, PDGFR, BTK
JNJ-38877605
T6095
Synonym:
Target: c-Met/HGFR
Su1498
T3980
Synonym: Tyrphostin SU 1498,AG 1498
Target: VEGFR
Dacomitinib
T2483
Synonym: PF-299804,PF-00299804,PF299
Target: Apoptosis, EGFR
Lorlatinib
T3061
Synonym: PF-6463922,PF-06463922,Loratinib
Target: Apoptosis, Tyrosine Kinases, ROS, ALK, ROS Kinase
Bosutinib hydrate
T63875
Synonym: PF-5208763 hydrate,PF-05208763 hydrate,SKI-606 hydrate
Target: Bcr-Abl, Src
Falnidamol
TQ0271
Synonym: BIBX 1382
Target: EGFR
Midostaurin
T3211
Synonym: N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251
Target: Others, PKC
Crizotinib
T1661
Synonym: PF-02341066
Target: c-Met/HGFR, ROS, ALK, Autophagy, ROS Kinase
JNJ-38158471
T22349
Synonym: CS-2660
Target: VEGFR, c-RET, c-Kit
Cerdulatinib hydrochloride
T6104
Synonym: Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride
Target: MLK, c-Fms, Tyrosine Kinases, Hippo pathway, JAK, Syk
Dasatinib monohydrate
T1448L
Synonym: BMS-354825 Monohydrate
Target: Apoptosis, Bcr-Abl, Src, c-Kit, Ephrin Receptor, Autophagy
Pyridone 6
T3080
Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I
Target: Tyrosine Kinases, JAK
Regorafenib Hydrochloride
T8402
Synonym: BAY73-4506 hydrochloride
Target: Raf, VEGFR, c-RET, PDGFR, Autophagy
SU4312
T3570
Synonym: SU 4312,NSC 86429
Target: VEGFR, PDGFR
BMS-754807
T2349
Synonym:
Target: Trk receptor, c-Met/HGFR, IGF-1R
AAL-993
T21593
Synonym:
Target: VEGFR
MNS
T6594
Synonym:
Target: Syk, Src, p97
Epidermal Growth Factor Receptor Peptide Acetate
T21723L
Synonym: Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base)
Target: Others
(Rac)-SAR131675
T3691
Synonym: SAR131675
Target: VEGFR
Pazopanib
T0097L
Synonym: GW786034
Target: VEGFR, FGFR, PDGFR, c-Kit, Autophagy
KW-2450 free base
T68405
Synonym:
Target: IGF-1R
TAK-659 hydrochloride
T4209
Synonym: TAK-659
Target: VEGFR, FLT, Tyrosine Kinases, JAK, Syk
LCB 03-0110 dihydrochloride
T32613
Synonym:
Target: Src
Dacomitinib hydrate
T19965
Synonym: PF 299804,PF00299804,PF 00299804,PF-00299804,PF299804,PF-299804
Target: EGFR
1 2 3
Cat No. Product Name Synonyms Targets
T5S0761 Nitidine chloride Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T22974 Methyl 2,5-dihydroxycinnamate EGFR
EGF receptor-associated tyrosine kinases inhibitor
T2336 Vitamin K2 Menatetrenone Endogenous Metabolite
Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signaling of certain tyrosine kinases, thereby affecting several...
TN1440 Beta-Hydroxyisovalerylshikonin EGFR , Tyrosine Kinases , Prostaglandin Receptor , Src , AMPK , Fatty Acid Synthase
Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly de...
Fr16741 Oxindole Indolin-2-one Others , HIV Protease
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases ...
T0610 Piceatannol trans-Piceatannol,Astringenin Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy
Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is...
TN3042 4-Hydroxycinnamamide ATPase , EGFR , Potassium Channel , p38 MAPK , Calcium Channel , Sodium Channel , AMPK
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-05779 Ephrin A1/EFNA1 Protein, Human, Recombinant (hFc) Human HEK293
EPH-related receptor tyrosine kinase ligand 1 (abbreviated as Ephrin-A1) also known as ligand of eph-related kinase 1 or EFNA1, is a member of the ephrin (EPH) family. The Eph family receptor interacting proteins (ephrin...
TMPY-04384 Src Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C...
TMPY-04125 PTP1B Protein, Human, Recombinant (His) Human E. coli
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c...
TMPY-01289 DDR1 Protein, Human, Recombinant (His) Human HEK293
Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracell...
TMPY-01389 HER3/ERBB3 Protein, Human, Recombinant (His) Human HEK293
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-00246 HER3/ERBB3 Protein, Rhesus, Recombinant Rhesus HEK293
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-03484 TCPTP Protein, Human, Recombinant Human Baculovirus-Insect Cells
Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein that belongs to the protein-tyrosine phosphatase family and Non-receptor class 1...
TMPY-05308 CD45 Protein, Human, Recombinant (aa 1-529, His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00399 HER3/ERBB3 Protein, Human, Recombinant Human HEK293
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-02477 HER3/ERBB3 Protein, Rhesus, Recombinant (His) Rhesus HEK293
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-02365 HER3/ERBB3 Protein, Mouse, Recombinant (His) Mouse HEK293
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-03024 HER3/ERBB3 Protein, Rat, Recombinant (His) Rat HEK293
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-04956 HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated Human HEK293
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-05748 CD45 Protein, Human, Recombinant (aa 26-577, His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPJ-00166 SCF Protein, Mouse, Recombinant Mouse E. coli
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gameto...
TMPY-05588 EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell ...
TMPJ-00412 VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) Human Human Cells
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 ...
TMPY-01936 VEGFR3/FLT4 Protein, Mouse, Recombinant (His) Mouse HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-01601 AXL Protein, Human, Recombinant (His) Human HEK293
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip...
TMPY-00949 VEGFR3/FLT4 Protein, Human, Recombinant (His) Human HEK293
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-05338 IL-10R alpha/IL-10RA Protein, Human, Recombinant (His) Human HEK293
IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPY-05496 IL-10R alpha/IL-10RA Protein, Mouse, Recombinant (hFc) Mouse HEK293
IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPY-01703 TREM-2 Protein, Mouse, Recombinant (His) Mouse HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-01608 Decorin Protein, Human, Recombinant (His) Human HEK293
Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core p...
TMPY-01148 TREM-2 Protein, Human, Recombinant (His) Human HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-00432 TREM-2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPK-00413 ROR1 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) Human,Cynomolgus,Rhesus macaque HEK293
ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1),  is a member of  the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR ...
TMPK-00572 ROR1 Protein, Canine, Recombinant (His) Canine HEK293
ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1),  is a member of  the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR ...
TMPY-04411 YES1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 /...
TMPK-00523 FLT3 Protein, Cynomolgus, Recombinant (hFc) Cynomolgus HEK293
The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re...
TMPK-00416 FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated Human CHO
The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re...
TMPY-03125 SHP-2 Protein, Mouse, Recombinant (His) Mouse HEK293
SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric ac...
TMPK-00876 G-CSFR/CD114 Protein, Mouse, Recombinant (His) Mouse HEK293
The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) ...
TMPY-01067 EphB2 Protein, Human, Recombinant (His) Human HEK293
Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPY-04216 EphB2 Protein, Mouse, Recombinant (His) Mouse HEK293
Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPY-04436 EphB1 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPK-00577 ROR2 Protein, Human, Recombinant (His & Avi) Human HEK293
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve...
TMPK-00579 ROR2 Protein, Human, Recombinant (hFc) Human HEK293
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve...
TMPK-00578 ROR2 Protein, Human, Recombinant (aa 34-403, His & Avi), Biotinylated Human HEK293
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve...
TMPK-00566 ROR2 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2) is a member of the ROR family of receptor tyrosine kinases and is important for skeletal development, including bone and cartilage formation, as well as for the deve...
TMPH-02277 PTPN11 Protein, Human, Recombinant (T253M & Q257L, His) Human E. coli
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosph...
TMPY-00784 EphB2 Protein, Human, Recombinant (His & hFc) Human HEK293
Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPY-03922 EphB1 Protein, Rhesus, Recombinant (His) Rhesus HEK293
Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPY-04416 EphB1 Protein, Human, Recombinant (aa 565-984, His & GST) Human Baculovirus-Insect Cells
Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPY-00042 EphB3 Protein, Rat, Recombinant (His) Rat HEK293
Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA...
TMPY-01784 EphB3 Protein, Mouse, Recombinant (His) Mouse HEK293
Ephrin type-B receptor 3, also known as EphB3 or HEK2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA...
TMPY-03621 EphB2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Ephrin type-B receptor 2, also known as EphB2, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPY-02206 EphB1 Protein, Mouse, Recombinant (His) Mouse HEK293
Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
TMPY-01997 EphB1 Protein, Human, Recombinant (His) Human HEK293
Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5...
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Ephrin A1/EFNA1 Protein, Human, Recombinant (hFc)
TMPY-05779
Species: Human
Expression System: HEK293
Src Protein, Human, Recombinant (His & GST)
TMPY-04384
Species: Human
Expression System: Baculovirus-Insect Cells
PTP1B Protein, Human, Recombinant (His)
TMPY-04125
Species: Human
Expression System: E. coli
DDR1 Protein, Human, Recombinant (His)
TMPY-01289
Species: Human
Expression System: HEK293
HER3/ERBB3 Protein, Human, Recombinant (His)
TMPY-01389
Species: Human
Expression System: HEK293
HER3/ERBB3 Protein, Rhesus, Recombinant
TMPY-00246
Species: Rhesus
Expression System: HEK293
TCPTP Protein, Human, Recombinant
TMPY-03484
Species: Human
Expression System: Baculovirus-Insect Cells
CD45 Protein, Human, Recombinant (aa 1-529, His)
TMPY-05308
Species: Human
Expression System: HEK293
HER3/ERBB3 Protein, Human, Recombinant
TMPY-00399
Species: Human
Expression System: HEK293
HER3/ERBB3 Protein, Rhesus, Recombinant (His)
TMPY-02477
Species: Rhesus
Expression System: HEK293
HER3/ERBB3 Protein, Mouse, Recombinant (His)
TMPY-02365
Species: Mouse
Expression System: HEK293
HER3/ERBB3 Protein, Rat, Recombinant (His)
TMPY-03024
Species: Rat
Expression System: HEK293
HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated
TMPY-04956
Species: Human
Expression System: HEK293
CD45 Protein, Human, Recombinant (aa 26-577, His)
TMPY-05748
Species: Human
Expression System: HEK293
SCF Protein, Mouse, Recombinant
TMPJ-00166
Species: Mouse
Expression System: E. coli
EphA2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-05588
Species: Human
Expression System: HEK293
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
TMPJ-00412
Species: Human
Expression System: Human Cells
VEGFR3/FLT4 Protein, Mouse, Recombinant (His)
TMPY-01936
Species: Mouse
Expression System: HEK293
AXL Protein, Human, Recombinant (His)
TMPY-01601
Species: Human
Expression System: HEK293
VEGFR3/FLT4 Protein, Human, Recombinant (His)
TMPY-00949
Species: Human
Expression System: HEK293
C-ABL/ABL1 Protein, Human, Recombinant (GST)
TMPY-04396
Species: Human
Expression System: Baculovirus-Insect Cells
IL-10R alpha/IL-10RA Protein, Human, Recombinant (His)
TMPY-05338
Species: Human
Expression System: HEK293
IL-10R alpha/IL-10RA Protein, Mouse, Recombinant (hFc)
TMPY-05496
Species: Mouse
Expression System: HEK293
TREM-2 Protein, Mouse, Recombinant (His)
TMPY-01703
Species: Mouse
Expression System: HEK293
Decorin Protein, Human, Recombinant (His)
TMPY-01608
Species: Human
Expression System: HEK293
TREM-2 Protein, Human, Recombinant (His)
TMPY-01148
Species: Human
Expression System: HEK293
TREM-2 Protein, Mouse, Recombinant (hFc)
TMPY-00432
Species: Mouse
Expression System: HEK293
ROR1 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi)
TMPK-00413
Species: Human,Cynomolgus,Rhesus macaque
Expression System: HEK293
ROR1 Protein, Canine, Recombinant (His)
TMPK-00572
Species: Canine
Expression System: HEK293
YES1 Protein, Human, Recombinant (His & GST)
TMPY-04411
Species: Human
Expression System: Baculovirus-Insect Cells
FLT3 Protein, Cynomolgus, Recombinant (hFc)
TMPK-00523
Species: Cynomolgus
Expression System: HEK293
FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00416
Species: Human
Expression System: CHO
SHP-2 Protein, Mouse, Recombinant (His)
TMPY-03125
Species: Mouse
Expression System: HEK293
G-CSFR/CD114 Protein, Mouse, Recombinant (His)
TMPK-00876
Species: Mouse
Expression System: HEK293
EphB2 Protein, Human, Recombinant (His)
TMPY-01067
Species: Human
Expression System: HEK293
EphB2 Protein, Mouse, Recombinant (His)
TMPY-04216
Species: Mouse
Expression System: HEK293
EphB1 Protein, Mouse, Recombinant (His & GST)
TMPY-04436
Species: Mouse
Expression System: Baculovirus-Insect Cells
ROR2 Protein, Human, Recombinant (His & Avi)
TMPK-00577
Species: Human
Expression System: HEK293
ROR2 Protein, Human, Recombinant (hFc)
TMPK-00579
Species: Human
Expression System: HEK293
ROR2 Protein, Human, Recombinant (aa 34-403, His & Avi), Biotinylated
TMPK-00578
Species: Human
Expression System: HEK293
ROR2 Protein, Cynomolgus, Recombinant (His)
TMPK-00566
Species: Cynomolgus
Expression System: HEK293
PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)
TMPH-02277
Species: Human
Expression System: E. coli
EphB2 Protein, Human, Recombinant (His & hFc)
TMPY-00784
Species: Human
Expression System: HEK293
EphB1 Protein, Rhesus, Recombinant (His)
TMPY-03922
Species: Rhesus
Expression System: HEK293
EphB1 Protein, Human, Recombinant (aa 565-984, His & GST)
TMPY-04416
Species: Human
Expression System: Baculovirus-Insect Cells
EphB3 Protein, Rat, Recombinant (His)
TMPY-00042
Species: Rat
Expression System: HEK293
EphB3 Protein, Mouse, Recombinant (His)
TMPY-01784
Species: Mouse
Expression System: HEK293
EphB2 Protein, Mouse, Recombinant (hFc)
TMPY-03621
Species: Mouse
Expression System: HEK293
EphB1 Protein, Mouse, Recombinant (His)
TMPY-02206
Species: Mouse
Expression System: HEK293
EphB1 Protein, Human, Recombinant (His)
TMPY-01997
Species: Human
Expression System: HEK293
Cat No. Product Name
L2200 Tyrosine Kinase Inhibitor Library

1033 compounds
A unique collection of 1033 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L9410 Covalent Inhibitor Library

1949 compounds
A unique collection of 1949 covalent Inhibitors and other molecules with common warheads like chloroacetyl,2-Chloropropionyl,Acryloyl,sulfonyl fluoride, alkyne,acrylamide, ketocarbonyl,disulfide bond, etc.
TargetMol