T3560 |
Desmethylanethol trithione
|
18274-81-2
|
98.23%
|
|
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen d...
|
T0374 |
Sunitinib Malate
|
341031-54-7
|
98.23%
|
|
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-...
|
T2456 |
Tivozanib
|
475108-18-0
|
98.23%
|
|
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and anti...
|
T30855 |
CGP77675
|
234772-64-6
|
98.23%
|
|
CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and au...
|
T0374L |
Sunitinib
|
557795-19-4
|
98.22%
|
|
Sunitinib (SU 11248), a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 nM and 80 nM and also inhibits c-Kit.
|
T6003 |
GSK1904529A
|
1089283-49-7
|
98.2%
|
|
GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
|
T4053 |
AST 487
|
630124-46-8
|
98.17%
|
|
AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
|
T2642 |
PD173074
|
219580-11-7
|
98.15%
|
|
PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
|
T26852 |
BMS-605541
|
639858-32-5
|
98.07%
|
|
BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).
|
T3641 |
NVP-BAW2881
|
861875-60-7
|
98.07%
|
|
NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit ...
|
T22349 |
JNJ-38158471
|
951151-97-6
|
98.04%
|
|
JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such ...
|
TQ0059 |
Ilorasertib
|
1227939-82-3
|
98.03%
|
|
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It als...
|
T10157 |
Regorafénib N-oxyde (M2)
|
835621-11-9
|
98.03%
|
|
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2...
|
T3250 |
Royal Jelly acid
|
14113-05-4
|
98.02%
|
|
Royal Jelly acid (Queen Bee Acid) is an inhibitor of VEGF-induced angiogenesis, cell migration and proliferation.
|
T7123 |
AMG-47a
|
882663-88-9
|
98%
|
|
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the lev...
|
T7203 |
Oglufanide
|
38101-59-6
|
98%
|
|
Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator,and inhibits vascular endothelial growth factor (VEGF).
|
T5S1632 |
Barlerin
|
57420-46-9
|
98%
|
|
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced inj...
|
T2358 |
ENMD-2076
|
934353-76-1
|
98%
|
|
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
|
T7394 |
Toceranib Phosphate
|
874819-74-6
|
98%
|
|
Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Fl...
|
TQ0166 |
Tesevatinib
|
781613-23-8
|
97.89%
|
|
Tesevatinib (XL-647) is an orally available, multi-target tyrosine kinase inhibitor (IC50s: 0.3, 16, 1.5, 8.7, and 1.4 nM for EGFR, ErbB2, KDR, Flt4, and EphB4)....
|