Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).

Cat. No.	Product name	CAS No.	Purity
T6516	Golgicide A	1139889-93-2	99.93%
T6516	Golgicide A is a potent and rapidly reversible GBF1 inhibitor.
T0433	Artesunate	88495-63-0	99.91%
T0433	Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and m...
T2926	Schizandrin A	61281-38-7	99.91%
T2926	Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM ...
T11138L	LHF-535	1450929-77-7	99.90%
T11138L	LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
T4536	Pleconaril	153168-05-9	99.88%
T4536	Pleconaril (VP 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).
T6377	Aloperine	56293-29-9	99.88%
T6377	Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
T36432	A2ti-1	570390-00-0	99.86%
T36432	A2ti-1 is a highly selective inhibitor of annexin A2/S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-acti...
T5S2360	Corydaline	518-69-4	99.86%
T5S2360	1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric ...
T2616	PIK-93	593960-11-3	99.83%
T2616	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T3717	Hinokitiol	499-44-5	99.78%
T3717	Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the a...
T1670	Lanatoside C	17575-22-3	99.76%
T1670	Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular h...
T6S1315	Oroxylin A	480-11-5	99.67%
T6S1315	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses...
T0188	Fluticasone (propionate)	80474-14-2	99.65%
T0188	Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid recep...
T2741	Glycyrrhizic acid	1405-86-3	99.62%
T2741	Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
T9957	LASV inhibitor 3.3	554438-52-7	99.55%
T9957	LASV inhibitor 3.3 is an inhibitor of Lassa fever virus (LASV) targeting lysosome-associated membrane protein 1 (LAMP1), a host factor that binds to the LASV gly...
TN2111	Prunin	529-55-5	99.52%
TN2111	Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate g...
T2774	Lycorine hydrochloride	2188-68-3	99.49%
T2774	Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.
T72041	Flaviviruses-IN-2	1009762-84-8	99.44%
T72041	Flaviviruses-IN-2 is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces West Nile virus (WNV) protease activity and inhibits WNV by 56%.
T4061	LY2334737	892128-60-8	99.4%
T4061	LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
T67777	Flaviviruses-IN-3	420090-97-7	99.39%
T67777	Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruse. Flaviviruses-IN-3 could reduce the WNV (West Nile virus) protease activity, with a inhibiti...