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Cytoskeletal Signaling Wnt/beta-catenin

Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine).Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part by the SPATS1 gene. The noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell. The noncanonical Wnt/calcium pathway regulates calcium inside the cell.
Cat No. Product Name
T0738 Urea Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...
T1971 WAY-262611 WAY-262611 is a wingless β-Catenin agonist.
T2003 Isx 9 ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.
T2052 KY02111 KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
T2237 ICG001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM,...
T2413 FH535 FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T2651 IWR-1-endo IWR-1, a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
T2702 IWP-2 IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
T2818 Methyl Vanillate Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovarie...
T3144 Wnt agonist 1 Wnt agonist 1 (BML-284) is a potent, selective and ,cell-permeable Wnt signaling activator.
T4011 NCB-0846 NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
T4043 ETC-159 ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
T4245 IWP 4 IWP-4 is a potent Wnt inhibitor.
T6868 KYA1797K KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
T6989 SKL2001 SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
T4302 iCRT3 iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
T4476 AS1517499 AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
T3S0153 Xanthatin 1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NS...
T5S0754 Isoquercitrin 1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therape...
T4468 WAY 316606 WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
TL0007 Bisdemethoxycurcumin Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
TL0008 Gigantol Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β...
T4486 iCRT 14 iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
T1878 XAV-939HOT XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
T5636 Adavivint (SM04690) Adavivint (SM04690) is a Wnt pathway inhibitor.
T5642 BC2059 BC2059 is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
T5729 L-quebrachitol L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-cateni...
T7204 PNU 74654 PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt ...
T7333 Pyrvinium pamoate Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition...
T7399 LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
TQ0215 Salinomycin sodium salt Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
T7830 Windorphen Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.
T6768 AZ6102 AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
T3261 NVP-TNKS656 NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T3168 MN-64 MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
T3062 WIKI4 WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T6842 G007-LK G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T1807 JW55 JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T8005 Cardiogenol C hydrochloride Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
T8400 Pamidronic acid Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
TN1103 Diphyllin Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
TN1694 Gliotoxin Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signali...
T12537 β-catenin/CBP-IN-1 β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
T10904 CWP232228 CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 i...
T14907 CCT251545 CCT251545 is an orally bioavailable inhibitor of WNT (IC50: 5 nM in 7dF3 cells).
T15137 DK419 DK419 is an orally active inhibitor of Wnt/β-catenin signaling (IC50: 0.19 μM). DK419 decreases protein levels of Axin2, β-catenin, c-Myc, Cyclin D1, and Su...
T13078 Tankyrase-IN-2 Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
T11190 EMT inhibitor-1 EMT inhibitor -1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
T11571 HLY78 HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt sig...
T15633 JW74 JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).
Urea
T0738CAS 57-13-6
Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...
WAY-262611
T1971CAS 1123231-07-1
WAY-262611 is a wingless β-Catenin agonist.
Isx 9
T2003CAS 832115-62-5
ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.
KY02111
T2052CAS 1118807-13-8
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
ICG001
T2237CAS 847591-62-2
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM,...
FH535
T2413CAS 108409-83-2
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
IWR-1-endo
T2651CAS 1127442-82-3
IWR-1, a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
IWP-2
T2702CAS 686770-61-6
IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
Methyl Vanillate
T2818CAS 3943-74-6
Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovarie...
Wnt agonist 1
T3144CAS 853220-52-7
Wnt agonist 1 (BML-284) is a potent, selective and ,cell-permeable Wnt signaling activator.
NCB-0846
T4011CAS 1792999-26-8
NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
ETC-159
T4043CAS 1638250-96-0
ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
IWP 4
T4245CAS 686772-17-8
IWP-4 is a potent Wnt inhibitor.
KYA1797K
T6868CAS 1956356-56-1
KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
SKL2001
T6989CAS 909089-13-0
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
iCRT3
T4302CAS 901751-47-1
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
AS1517499
T4476CAS 919486-40-1
AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
Xanthatin
T3S0153CAS 26791-73-1
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NS...
Isoquercitrin
T5S0754CAS 482-35-9
1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therape...
WAY 316606
T4468CAS 915759-45-4
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
Bisdemethoxycurcumin
TL0007CAS 24939-16-0
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
Gigantol
TL0008CAS 67884-30-4
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β...
iCRT 14
T4486CAS 677331-12-3
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
XAV-939 HOT
T1878CAS 284028-89-3
XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
Adavivint (SM04690)
T5636CAS 1467093-03-3
Adavivint (SM04690) is a Wnt pathway inhibitor.
BC2059
T5642CAS 1227637-23-1
BC2059 is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
L-quebrachitol
T5729CAS 642-38-6
L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-cateni...
PNU 74654
T7204CAS 113906-27-7
PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt ...
Pyrvinium pamoate
T7333CAS 3546-41-6
Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition...
LF3
T7399CAS 664969-54-4
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
Salinomycin sodium salt
TQ0215CAS 55721-31-8
Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
Windorphen
T7830CAS 19881-70-0
Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.
AZ6102
T6768CAS 1645286-75-4
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 ...
NVP-TNKS656
T3261CAS 1419949-20-4
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
MN-64
T3168CAS 92831-11-3
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
WIKI4
T3062CAS 838818-26-1
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
G007-LK
T6842CAS 1380672-07-0
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
JW55
T1807CAS 664993-53-7
JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
Cardiogenol C hydrochloride
T8005CAS 1049741-55-0
Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
Pamidronic acid
T8400CAS 40391-99-9
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
Diphyllin
TN1103CAS 22055-22-7
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
Gliotoxin
TN1694CAS 67-99-2
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signali...
β-catenin/CBP-IN-1
T12537CAS 1198780-38-9
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
CWP232228
T10904CAS 1144044-02-9
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 i...
CCT251545
T14907CAS 1661839-45-7
CCT251545 is an orally bioavailable inhibitor of WNT (IC50: 5 nM in 7dF3 cells).
DK419
T15137CAS 2102672-22-8
DK419 is an orally active inhibitor of Wnt/β-catenin signaling (IC50: 0.19 μM). DK419 decreases protein levels of Axin2, β-catenin, c-Myc, Cyclin D1, and Su...
Tankyrase-IN-2
T13078CAS 1588870-36-3
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
EMT inhibitor-1
T11190CAS 1638526-21-2
EMT inhibitor -1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
HLY78
T11571CAS 854847-61-3
HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt sig...
JW74
T15633CAS 863405-60-1
JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).