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Wnt/beta-catenin

T0738	Urea	Urea is formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end metabolite of protein catabolism and accounts for a...
T1971	WAY-262611	WAY-262611 is a wingless β-Catenin agonist.
T2003	Isx 9	ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.
T2052	KY02111	KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
T2237	ICG001	ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM,...
T2413	FH535	FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T2651	IWR-1-endo	IWR-1, a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
T2702	IWP-2	IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively blocks Porcn-mediated Wnt palmitoylation.
T2818	Methyl Vanillate	Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovarie...
T3144	Wnt agonist 1	Wnt agonist 1 (BML-284) is a potent, selective and ,cell-permeable Wnt signaling activator.
T4011	NCB-0846	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
T4043	ETC-159	ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
T4245	IWP 4	IWP-4 is a potent Wnt inhibitor.
T6868	KYA1797K	KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
T6989	SKL2001	SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
T4302	iCRT3	iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
T4476	AS1517499	AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
T3S0153	Xanthatin	1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NS...
T5S0754	Isoquercitrin	1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therape...
T4468	WAY 316606	WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
TL0007	Bisdemethoxycurcumin	Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydrox...
TL0008	Gigantol	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β...
T4486	iCRT 14	iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
T1878	XAV-939	XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
T5636	Adavivint (SM04690)	Adavivint (SM04690) is a Wnt pathway inhibitor.
T5642	BC2059	BC2059 is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
T5729	L-quebrachitol	L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-cateni...
T7204	PNU 74654	PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt ...
T7333	Pyrvinium pamoate	Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition...
T7399	LF3	LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)

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