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Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN3468 Atractylochromene 203443-33-8 98%
Atractylochromene
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo...
TN1694 Gliotoxin 67-99-2 98%
Gliotoxin
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
TN3525 Boehmenan 57296-22-7 98%
Boehmenan
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN3319 9-Hydroxycanthin-6-one 138544-91-9 98%
9-Hydroxycanthin-6-one
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
TMA1743 Ergosterol peroxide 2061-64-5 98%
Ergosterol peroxide
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN2995 4,10-Aromadendranediol 70051-38-6 98%
4,10-Aromadendranediol
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN2775 2-Methoxystypandrone 85122-21-0 98%
2-Methoxystypandrone
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
T12537 β-catenin/CBP-IN-1 1198780-38-9 98%
β-catenin/CBP-IN-1
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
TP1565L Foxy-5 acetate TP1565L 98%
Foxy-5 acetate
Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer ...
TN4046 Excisanin A 78536-37-5 98%
Excisanin A
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T35556 GSK-3β inhibitor 8 1139875-74-3 98%
GSK-3β inhibitor 8
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine deriva...
T13078 Tankyrase-IN-2 1588870-36-3 98%
Tankyrase-IN-2
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
T5342 IWP-O1 2074607-48-8 99.98%
IWP-O1
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
T6673 SKI II 312636-16-1 99.97%
SKI II
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases inclu...
T0470 Nefopam hydrochloride 23327-57-3 99.97%
Nefopam hydrochloride
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
T7830 Windorphen 19881-70-0 99.96%
Windorphen
Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.
T17256 Wnt pathway activator 1 1360540-81-3 99.94%
Wnt pathway activator 1
Wnt pathway activator 1 is a potent Wnt activator (IC50s: 28-29 nM).
T6768 AZ6102 1645286-75-4 99.91%
AZ6102
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 c...
TP1263 Fz7-21 2247635-23-8 99.8%
Fz7-21
Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impair...
T8820 BML-284 hydrochloride 2095432-75-8 99.79%
BML-284 hydrochloride
BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.
Atractylochromene
TN3468
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo...
Gliotoxin
TN1694
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
9-Hydroxycanthin-6-one
TN3319
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
Ergosterol peroxide
TMA1743
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
4,10-Aromadendranediol
TN2995
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
β-catenin/CBP-IN-1
T12537
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
Foxy-5 acetate
TP1565L
Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer ...
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
GSK-3β inhibitor 8
T35556
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine deriva...
Tankyrase-IN-2
T13078
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
IWP-O1
T5342
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
SKI II
T6673
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases inclu...
Nefopam hydrochloride
T0470
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
Windorphen
T7830
Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.
Wnt pathway activator 1
T17256
Wnt pathway activator 1 is a potent Wnt activator (IC50s: 28-29 nM).
AZ6102
T6768
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 c...
Fz7-21
TP1263
Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impair...
BML-284 hydrochloride
T8820
BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.
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