Home Tools
Log in
Cart

Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T9662 SRI 37892 1030769-75-5 98.92%
SRI 37892
SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.
T4S2126 Ginkgetin 481-46-9 98.91%
Ginkgetin
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against...
T22775 Exo-IWR-1 1127442-87-8 98.85%
exo-IWR-1
exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin s...
T5S1058 Triptonide 38647-11-9 98.8%
Triptonide
1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-in...
TN7036 N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide 883715-23-9 98.66%
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem c...
T13004 SSTC3 1242422-09-8 98.65%
SSTC3
SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastom...
T23602 ABC99 2331255-53-7 98.65%
ABC99
ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the s...
T2237 ICG001 847591-62-2 98.63%
ICG001
ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with ...
T2310 CHIR-99021 252917-06-9 98.63%
CHIR-99021
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021...
T21685 CCT 031374 hydrobromide 1219184-91-4 98.61%
CCT 031374 hydrobromide
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.
T11284 FIDAS-3 1266684-01-8 98.59%
FIDAS-3
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and is a p...
T1716 Echinacoside 82854-37-3 98.58%
Echinacoside
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neu...
T2651 IWR-1 1127442-82-3 98.46%
IWR-1
IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
T7333 Pyrvinium pamoate 3546-41-6 98.43%
Pyrvinium pamoate
Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug du...
T72437 PARP1/2/TNKS1/2-IN-1 2243453-32-7 98.40%
PARP1/2/TNKS1/2-IN-1
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis....
T77675 TNKS-2-IN-1 4765-59-7 98.4%
TNKS-2-IN-1
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity ag...
T4302 ICRT3 901751-47-1 98.32%
iCRT3
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
T13345 Wnt pathway activator 2 1360540-82-4 98.28%
Wnt pathway activator 2
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
T9151 Teplinovivint 1428064-91-8 98.27%
Teplinovivint
Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. It has anti-inflammatory activity and has the potential for tendinopathy research.
T2003 ISX-9 832115-62-5 98.26%
ISX-9
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
SRI 37892
T9662
SRI 37892 is a Fzd7 inhibitor with potent activities against Wnt/β-catenin signaling and cancer cell viability.
Ginkgetin
T4S2126
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against...
exo-IWR-1
T22775
exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin s...
Triptonide
T5S1058
1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-in...
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
TN7036
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem c...
SSTC3
T13004
SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastom...
ABC99
T23602
ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the s...
ICG001
T2237
ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with ...
CHIR-99021
T2310
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021...
CCT 031374 hydrobromide
T21685
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.
FIDAS-3
T11284
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and is a p...
Echinacoside
T1716
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neu...
IWR-1
T2651
IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
Pyrvinium pamoate
T7333
Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug du...
PARP1/2/TNKS1/2-IN-1
T72437
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis....
TNKS-2-IN-1
T77675
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity ag...
iCRT3
T4302
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
Wnt pathway activator 2
T13345
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
Teplinovivint
T9151
Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. It has anti-inflammatory activity and has the potential for tendinopathy research.
ISX-9
T2003
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
1 2 3 4 5 6 7
TargetMol