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Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T21685 CCT 031374 hydrobromide 1219184-91-4 98.61%
CCT 031374 hydrobromide
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.
T11284 FIDAS-3 1266684-01-8 98.59%
FIDAS-3
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by...
T1716 Echinacoside 82854-37-3 98.58%
Echinacoside
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neu...
T2651 IWR-1 1127442-82-3 98.46%
IWR-1
IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
T7333 Pyrvinium pamoate 3546-41-6 98.43%
Pyrvinium pamoate
Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug du...
T72437 PARP1/2/TNKS1/2-IN-1 2243453-32-7 98.40%
PARP1/2/TNKS1/2-IN-1
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis....
T77675 TNKS-2-IN-1 4765-59-7 98.4%
TNKS-2-IN-1
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity ag...
T4302 ICRT3 901751-47-1 98.32%
iCRT3
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
T13345 Wnt pathway activator 2 1360540-82-4 98.28%
Wnt pathway activator 2
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
T9151 Teplinovivint 1428064-91-8 98.27%
Teplinovivint
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy res...
T5636 Adavivint 1467093-03-3 98.27%
Adavivint
Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
T2003 ISX-9 832115-62-5 98.26%
ISX-9
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
T63516 NRX-252114 2763260-39-3 98.26%
NRX-252114
NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ...
T17142 Toxoflavin 84-82-2 98.24%
Toxoflavin
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.
T6842 G007-LK 1380672-07-0 98.17%
G007-LK
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T15137 DK419 2102672-22-8 98.15%
DK419
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 an...
T11793 KY-05009 1228280-29-2 98.06%
KY-05009
KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces...
T9025 KY19382 2226664-93-1 98.06%
KY19382
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CX...
T4245 IWP-4 686772-17-8 98%
IWP-4
IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.
T5642 Tegatrabetan 1227637-23-1 98%
Tegatrabetan
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
CCT 031374 hydrobromide
T21685
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.
FIDAS-3
T11284
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by...
Echinacoside
T1716
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neu...
IWR-1
T2651
IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
Pyrvinium pamoate
T7333
Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug du...
PARP1/2/TNKS1/2-IN-1
T72437
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis....
TNKS-2-IN-1
T77675
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity ag...
iCRT3
T4302
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
Wnt pathway activator 2
T13345
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
Teplinovivint
T9151
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy res...
Adavivint
T5636
Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
ISX-9
T2003
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
NRX-252114
T63516
NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ...
Toxoflavin
T17142
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.
G007-LK
T6842
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
DK419
T15137
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 an...
KY-05009
T11793
KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces...
KY19382
T9025
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CX...
IWP-4
T4245
IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.
Tegatrabetan
T5642
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
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TargetMol