T21685 |
CCT 031374 hydrobromide
|
1219184-91-4
|
98.61%
|
|
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.
|
T11284 |
FIDAS-3
|
1266684-01-8
|
98.59%
|
|
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by...
|
T1716 |
Echinacoside
|
82854-37-3
|
98.58%
|
|
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neu...
|
T2651 |
IWR-1
|
1127442-82-3
|
98.46%
|
|
IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
|
T7333 |
Pyrvinium pamoate
|
3546-41-6
|
98.43%
|
|
Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug du...
|
T72437 |
PARP1/2/TNKS1/2-IN-1
|
2243453-32-7
|
98.40%
|
|
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis....
|
T77675 |
TNKS-2-IN-1
|
4765-59-7
|
98.4%
|
|
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity ag...
|
T4302 |
ICRT3
|
901751-47-1
|
98.32%
|
|
iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.
|
T13345 |
Wnt pathway activator 2
|
1360540-82-4
|
98.28%
|
|
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
|
T9151 |
Teplinovivint
|
1428064-91-8
|
98.27%
|
|
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy res...
|
T5636 |
Adavivint
|
1467093-03-3
|
98.27%
|
|
Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
|
T2003 |
ISX-9
|
832115-62-5
|
98.26%
|
|
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.
|
T63516 |
NRX-252114
|
2763260-39-3
|
98.26%
|
|
NRX-252114 (NRX252114) induces degradation of mutant β-catenin NRX-252114 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ...
|
T17142 |
Toxoflavin
|
84-82-2
|
98.24%
|
|
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.
|
T6842 |
G007-LK
|
1380672-07-0
|
98.17%
|
|
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
|
T15137 |
DK419
|
2102672-22-8
|
98.15%
|
|
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 an...
|
T11793 |
KY-05009
|
1228280-29-2
|
98.06%
|
|
KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces...
|
T9025 |
KY19382
|
2226664-93-1
|
98.06%
|
|
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CX...
|
T4245 |
IWP-4
|
686772-17-8
|
98%
|
|
IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.
|
T5642 |
Tegatrabetan
|
1227637-23-1
|
98%
|
|
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
|