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Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2818 Methyl Vanillate 3943-74-6 100%
Methyl Vanillate
Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariect...
T67866 YW2036 2131223-92-0 100%
YW2036
YW2036 is an inhibitor of Wnt signaling pathway.
T77524 Carboxylesterase-IN-2 2764748-88-9 100%
Carboxylesterase-IN-2
Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.
T15363 FzM1.8 2204290-85-5 100%
FzM1.8
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and a...
T8005 Cardiogenol C hydrochloride 1049741-55-0 100%
Cardiogenol C hydrochloride
Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
T19355 Heparan Sulfate 9050-30-0
Heparan Sulfate
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
T2052 KY02111 1118807-13-8
KY02111
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
T77692 F7H 897109-93-2 98%
F7H
F7H is a potent Frizzled receptor FZD7 antagonist with an IC50 value of 1.25 μM.F7H is a potent ligand for the transmembrane structural domain (TMD) of FZD7, wit...
T77719 TNIK-IN-7 1417795-24-4 98%
TNIK-IN-7
TNIK-IN-7 is a potent and selective Traf2 and Nck interacting kinase (TNIK) inhibitor (IC50: 11 nM) with antitumor activity for studying signaling and proliferat...
T77733 TNKS-2-IN-2 2719726-91-5 98%
TNKS-2-IN-2
TNKS-2-IN-2 is a novel and potent TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breas...
T38776 LP-922056 1365060-22-5 98%
LP-922056
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
TN4583 Moringin 73255-40-0 98%
Moringin
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T4486 ICRT 14 677331-12-3 98%
iCRT 14
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
T9557 TNIK-IN-2 2754265-76-2 98%
TNIK-IN-2
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
T9696 β-catenin-IN-2 1458664-10-2 98%
β-catenin-IN-2
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
T6113 ICG-001 780757-88-2 98%
ICG-001
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related tr...
T3168 MN-64 92831-11-3 98%
MN-64
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
T27582 ICRT-5 18623-44-4 98%
iCRT-5
iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity, blocking Wnt/β-catenin expression and inducing apoptosis. iCRT-5 can be u...
T22884 JW 67 442644-28-2 98%
JW 67
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including ...
T2161 Cardiogenol C 671225-39-1 98%
Cardiogenol C
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
Methyl Vanillate
T2818
Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariect...
YW2036
T67866
YW2036 is an inhibitor of Wnt signaling pathway.
Carboxylesterase-IN-2
T77524
Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.
FzM1.8
T15363
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and a...
Cardiogenol C hydrochloride
T8005
Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
Heparan Sulfate
T19355
Heparan Sulfate is a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on th...
KY02111
T2052
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
F7H
T77692
F7H is a potent Frizzled receptor FZD7 antagonist with an IC50 value of 1.25 μM.F7H is a potent ligand for the transmembrane structural domain (TMD) of FZD7, wit...
TNIK-IN-7
T77719
TNIK-IN-7 is a potent and selective Traf2 and Nck interacting kinase (TNIK) inhibitor (IC50: 11 nM) with antitumor activity for studying signaling and proliferat...
TNKS-2-IN-2
T77733
TNKS-2-IN-2 is a novel and potent TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breas...
LP-922056
T38776
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
Moringin
TN4583
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
iCRT 14
T4486
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
TNIK-IN-2
T9557
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
β-catenin-IN-2
T9696
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
ICG-001
T6113
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related tr...
MN-64
T3168
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
iCRT-5
T27582
iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity, blocking Wnt/β-catenin expression and inducing apoptosis. iCRT-5 can be u...
JW 67
T22884
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including ...
Cardiogenol C
T2161
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
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TargetMol